Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients

Persson, Ingemar; Johansson, Inger; Yc, Lou; Qy, Yue; Ls, Duan; Bertilsson, Leif; Ingelman‐Sundberg, Magnus

doi:10.1002/(sici)1097-0215(19990505)81:3<325::aid-ijc2>3.0.co;2-s

Cited by 83 publications

(25 citation statements)

References 14 publications

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“…All were similar to those reported for Chinese populations. 9,15,17,[29][30][31][32][33][34] Among cases, no significant differences were found for the frequencies of all genotypes between Beijing and Tianjin.…”

Section: Methodsmentioning

confidence: 99%

“…6,[12][13][14][15][16][17][18][19][20][21][22] In the Chinese population, lung cancer is the leading cause of cancer deaths, and while SCC is still the predominant histological type, the rate for lung AC is increasing and AC is already the most common histological type in females.…”

Section: )mentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11] A number of studies have also investigated the association of the genetic polymorphism of CYP2E1 with lung cancer, but the effects remain unclear. 6,[12][13][14][15][16][17][18][19][20][21][22] In the Chinese population, lung cancer is the leading cause of cancer deaths, and while SCC is still the predominant histological type, the rate for lung AC is increasing and AC is already the most common histological type in females. 23) However, little is known about the impact of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms on the susceptibility to lung AC in Chinese.…”

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confidence: 99%

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Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: A case‐control study in Chinese population

Wang

Deng

et al. 2003

Cancer Science

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A case-control study of 164 lung adenocarcinoma (AC) patients with 181 age-and gender-matched healthy controls was conducted in order to assess any associations between glutathione-Stransferase M1 (GSTM1), cytochrome P4501A1 (CYP1A1) and cytochrome P4502E1 (CYP2E1) polymorphisms and susceptibility to lung AC in Chinese. The presence of CYP2E1 variant allele was significantly less frequent in cases than in controls, while the distribution of GSTM1 null genotype and variant CYP1A1 Msp1 allele did not vary between cases and controls. After adjustment for age, gender, smoking and all other genotypes, the CYP2E1 Rsa1 variant allele was significantly associated with decreased risk of lung AC [odds ratio 0.534 (95% confidence interval, 0.340-0.837)]. Furthermore, 3.0-fold increased risk was found in individuals with combined GSTM1 null genotype and CYP2E1 Rsa1 wild type versus those with combined GSTM1 non-null type and CYP2E1 variant allele. Our results suggest that CYP2E1 Rsa1 variant allele is associated with a decreased risk of lung AC, and combined GSTM1 null genotype and CYP2E1 Rsa1 wild type has a promoting effect on susceptibility to lung AC. (Cancer Sci 2003; 94: 448-452) hile lung cancer incidence is now decreasing in men in some countries, it still remains a major worldwide health problem, accounting for more than one-sixth of cancer deaths. 1) Furthermore, the incidence and proportion of lung adenocarcinoma (AC) cases have been increasing for several decades in many Asian, American and European countries, leading to a changing clinical picture characterized by early development of metastases.It is well established that lung cancers in men and women are largely attributable to cigarette smoking, and the trend for elevation of lung AC is also considered to be related to an increase in exposure to tobacco-specific nitrosamines (TSNAs) from low-tar cigarettes. However, it has also been reported that only less than 20% of smokers develop lung cancer, suggesting that genetic variations and other environmental factors also play important roles in determining individual differences in lung cancer susceptibility. 2)Genetic variations in metabolic activation or detoxification enzymes are thought to make a major contribution, including polymorphisms in glutathione-S-transferase M1 (GSTM1), cytochrome P4501A1 (CYP1A1) and cytochrome P4502E1 (CYP2E1). Although many studies have shown that GSTM1 null genotype and variant CYP1A1 alleles are associated with an increased risk of lung squamous cell carcinoma (SCC) independent of the ethnic background, the results regarding lung AC risk are still contradictory.3-11) A number of studies have also investigated the association of the genetic polymorphism of CYP2E1 with lung cancer, but the effects remain unclear. 6,[12][13][14][15][16][17][18][19][20][21][22] In the Chinese population, lung cancer is the leading cause of cancer deaths, and while SCC is still the predominant histological type, the rate for lung AC is increasing and AC is already the most common histological t...

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Section: Methodsmentioning

confidence: 99%

Section: )mentioning

confidence: 99%

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confidence: 99%

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Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: A case‐control study in Chinese population

Wang

Deng

et al. 2003

Cancer Science

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“…We tested whether genotype frequencies of controls were in agreement with HardyWeinberg equilibrium (HWE) using the x 2 test. (Qu et al, 1998) 1998 182 184 Hospital 0.002 (Wang et al, 1999) 1999 119 231 Hospital 0.437 (Persson et al, 1999(Persson et al, ) 1999 113 Population 0.635 (Huang et al, 2000) 2000 54 260 Hospital 0.039 (Li et al, 2000) 2000 92 137 Population 0.139 (Shi et al, 2002) 2002 120 120 Hospital 0.042 (Chen et al, 2002) 2002 91 138 Hospital 0.094 (Wang et al, 2003) 2003 164 181 Hospital 0.251 (Zou et al, 2004) 2004 41 61 Hospital 0.018 (Gu et al, 2007) 2007 279 684 Hospital Not estimable (Li et al, 2008) 2008 150 152 Hospital 0.155 (Liu et al, 2010) 2010 108 108 Population 0.28 (Su et al, 2011) 2011 64 64 Population 0.305 2012 217 198 Hospital 0.877 (Guo et al, 2012) 2012 684 602 Hospital 0.907 (Cao et al, 2013) 2013 526 526 Hospital 0.619 *HWE, Hardy Weinberg Equilibrium…”

Section: Quantitative Data Synthesismentioning

confidence: 99%

“…A series of studies have investigated the associations between CYP2E1 RsaI/PstI polymorphisms and lung cancer risk in Chinese population (Qu et al, 1998;Persson et al, 1999;Wang et al, 1999;Huang et al, 2000;Li et al, 2000;Chen et al, 2002;Shi et al, 2002;Wang et al, 2003;Zou et al, 2004;Gu et al, 2007;Li et al, 2008;Liu et al, 2010;Su et al, 2011;Guo et al, 2012;Cao et al, 2013). However, the results from epidemiologic studies were inconsistent and controversial.…”

Section: Introductionmentioning

confidence: 99%