Genetic Polymorphism of the Chemokine Co-Receptors CCR5, CXCR4 and CCR2 in Bulgarians Living with HIV

Host and/or viral factors involved in human polyomavirus (HPoV) infection in persons living with HIV remain unknown. A hypothesis is outlined suggesting the importance of the co‐receptors CCR5, CCR2, and CXCR4 not only for HIV, but also for HPoV. Functionally capable receptors coded by wild‐type (wt) genotypes could facilitate internalization of HPoV in the cell resulting in brain and/or kidney infection/s in HIV infected individuals. Forty‐nine Bulgarians with HIV, all treated by HAART, without neurological and/or kidney disorders, were tested for JCV and BKV and genotyped for CCR5 (CCR5del32), CCR2 (CCR2‐64I), and CXCR4 (SDF1‐3′A). In 27/49 (55.1%) individuals a co‐infection with HPoV was identified—BKV in 12/49 (24.5%), JCV—in another 12/49 (24.5%), and both viruses—in 3/49 (6.1%). A high frequency of wt CCR5 was found in patients with HPoV (91.7% for BKV and JCV and in 100% with both viruses). V/V of CCR2 was presented in 75% for BKV and JCV and in 66.7% for BKV plus JCV. SDF1‐3′G/G predominated in JCV infected patients (75%), while G/A and A/A genotypes were more frequent in patients with BKV (41.7%). Also, 21/22 (95.4%) persons without HPoV infection were heterozygous for SDF1 and CCR2. The number of individuals bearing wt of all co‐receptors in the group of persons not infected with HPoV was lower (P = 0.03) than that with polymorphism/s in one or two genes (SDF1 and CCR2) in the same group. The results suggest a probable role of co‐receptors used by HIV to facilitate infection with HPoV. J. Med. Virol. 82:8–13, 2010. © 2009 Wiley‐Liss, Inc.

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Do human polyoma viruses and human immunodeficiency virus share common co‐receptors?

Borissov

Tsekov

Gavazova

et al. 2009

Journal of Medical Virology

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Identification of Polyomavirus JC Genome Sequences in Two HIV-Associated PML Cases in Bulgaria

Tsekov

Kalvatchev

Kulev

et al. 2008

Biotechnology & Biotechnological Equipment

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Active replication of the Polyomavirus hominis 2 (JCV) in glial cells leads to the fatal, demyelinating disease of the central nervous system, called progressive multifocal leukoencephalopathy (PML). Although more than 80% of the population is infected a significant impairment of the immune system is needed for reactivation of the latent virus. Such reactivation can be verified by a Polymerase Chain Reaction (PCR) test for detection of JCV DNA in brain tissue or cerebrospinal fluid (CSF). Here we report and discuss two cases of Bulgarian HIV-infected patients where identification of JCV supported and confirmed the diagnosis of HIV-associated PML.

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Prediction of Relative Risk of AIDS Onset (RRA) Using Combined Three-Locus Genotype Data in Bulgarian Population

Borissov¹,

Savov²,

Argirova³

2008

Biotechnology & Biotechnological Equipment

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Genetic Polymorphism of the Chemokine Co-Receptors CCR5, CXCR4 and CCR2 in Bulgarians Living with HIV

Cited by 3 publications

References 20 publications

Do human polyoma viruses and human immunodeficiency virus share common co‐receptors?

Do human polyoma viruses and human immunodeficiency virus share common co‐receptors?

Identification of Polyomavirus JC Genome Sequences in Two HIV-Associated PML Cases in Bulgaria

Prediction of Relative Risk of AIDS Onset (RRA) Using Combined Three-Locus Genotype Data in Bulgarian Population

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