Genetic Polymorphism of Mycoplasmas: Variability of Cytoadhesin Genes in Clinical Isolates of Mycoplasma hominis

Gorshkov, Oleg; Чернов, В. М.; Чернова, О. А.; Baranova, N. B.; Akopian, T. A.

doi:10.1007/s10628-005-0105-8

Cited by 2 publications

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References 9 publications

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“…Исследователи считают, что, возможно, вариабельность данного гена и, как следствие, белка VAA определяет наличие или отсутствие вирулентных свойств M. hominis. В то же время большинство работ, посвященных генетическому полиморфизму M. hominis, сфокусированы на изучении молекулярной структуры гена vaa, а не на поиске взаимосвязи генетических вариантов микроорганизма с клиническими проявлениями воспалительных заболеваний мочеполового тракта [6][7][8]. Это прежде всего связано с техническими трудностями включения в одно исследова-ние рутинных клинических и лабораторных методов обследования и сложных трудоемких молекулярногенетических методик изучения генетических свойств микроорганизмов.…”

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Genetic variants of genital mycoplasmas and their relation to the clinical course of inflammatory diseases of the urogenital system in women

Rakhmatulina¹,

Plakhova²,

Кубанов³

2014

Vestnik dermatologii i venerologii

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Goal of the study. To study genetic variability of M. hominis (based on the vaa gene) and M. genitalium (based on the mg192 gene) derived from biological material samples taken from women with different clinical manifestations of inflammatory diseases of the urogenital system and clinically healthy women (for M. hominis). Materials and methods. Genetic variability of twenty M. hominis samples taken from patients with inflammatory diseases of the urogenital system and twenty M. hominis samples taken from patients without clinical and laboratory signs of inflammatory processes of the urogenital system was studied by the sequence analysis method. Genetic variability of eight M. genitalium samples taken from patients with different clinical signs of inflammatory diseases of the urogenital system was also examined by the sequence analysis method. Results. Three genetic variants of M. hominis based on the vaa gene were found; variant I was revealed more often in patients with clinical manifestations of inflammatory diseases (65.0%), and variant II - in clinically healthy women (60.0%). Three phylogenetic M. gentium groups based on the mg192 gene were revealed; two samples were referred to Groups I and II, and four samples were referred to Group III. Samples from each phylogenetic groups were taken from patients with clinical and laboratory manifestations of cervicitis and urethritis. Conclusion. The study data demonstrate a potential effect of the VAA surface protein on the virulence of opportunistic M. hominis pathogens.

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Genetic variants of genital mycoplasmas and their relation to the clinical course of inflammatory diseases of the urogenital system in women

Rakhmatulina¹,

Plakhova²,

Кубанов³

2014

Vestnik dermatologii i venerologii

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“…Показано, что именно изменчивость поверхностного белка VAA и вариабельность гена, его кодирующего, влияют на адгезивные свойства M. hominis. Исследователи предполагают, что эта генетическая вариабельность M. hominis может определять различные клинические проявления у инфицированных пациентов, но изучение взаимосвязи генетических вариантов и клинических проявлений не проводилось [11][12][13].…”

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Genetic variability of genital mycoplasmas and its clinical value

Plakhova

2015

Vestnik dermatologii i venerologii

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The article presents data on genetic variability of genital mycoplasmas. The author presents the results of genetic variability studies for M. hominis, gene vaa, U. parvum, gene mba, and M. genitalium, gene mg192, sampled from women with different clinical manifestations of inflammatory diseases of the urogenital system. Based on the molecular typing results for 138 samples of genital mycoplasmas, the author revealed a relationship between clinical manifestations of inflammatory diseases of the urogenital system caused by U. parvum and different U. parvum serovars as well as different genetic variations of M. hominis.Infection with 6 U. parvum serovar results in the development of inflammatory diseases of the urogenital tract accompanied by subjective manifestations (р < 0.05). Genetic variant II of М. hominis was revealed more often in patients with clinical manifestations of inflammatory diseases while variant I was revealed more often in patients infected with М. hominis without any signs of inflammation (р < 0.05). Genetic variants of M. genitalium were determined; no significant differences in terms of their prevalence in the examined patients were revealed.

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Genetic Polymorphism of Mycoplasmas: Variability of Cytoadhesin Genes in Clinical Isolates of Mycoplasma hominis

Cited by 2 publications

References 9 publications

Genetic variants of genital mycoplasmas and their relation to the clinical course of inflammatory diseases of the urogenital system in women

Genetic variants of genital mycoplasmas and their relation to the clinical course of inflammatory diseases of the urogenital system in women

Genetic variability of genital mycoplasmas and its clinical value

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