Genetic Polymorphism of Mitochondrial DNA in Dong, Gelao, Tujia, and Yi Ethnic Populations from Guizhou, China

Li, Binbin; Fuguang, Zhong; Yi, Hongsheng; Xianran, Wang; Liangfang, Li; Wang, Lilan; Qi, Xiaolan; Wu, Lifu

doi:10.1016/s1673-8527(07)60091-5

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…studied the haplotypes of 17 Y-STR loci and preformed the multidimensional scaling plot which also showed the close relationship between Tujia and Han population28; and the similar result was observed in the PCA plot based on the allelic frequencies of HLA-DRB1 locus29. The relatively far genetic relationships between Tujia group and Kazak or Uigur group were observed in the PCA map constructed by mtDNA haplogroup frequencies30 and in the abovementioned HLA-DRB1 PCA plot29, respectively.…”

Section: Resultssupporting

confidence: 59%

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Shen

Zhu

Yao

et al. 2016

Sci Rep

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In the present study, thirty autosomal insertion and deletion polymorphic loci were simultaneously amplified and genotyped in a multiplex system, and their allelic frequencies as well as several forensic parameters were obtained in a sample of 236 unrelated healthy Tujia individuals. All the loci were in Hardy-Weinberg equilibrium after applying a Bonferroni correction and all pair-wise loci showed no significant linkage disequilibrium. These loci were observed to be relatively informative and discriminating, quite efficient for forensic applications. Allelic frequencies of 30 loci were compared between the Tujia group and other reference populations, and the results of analysis of molecular variance indicated the Tujia group showed the least significant differences with the Shanghai Han at one locus, and the most with Central Spanish population at 22 loci. We analyzed the population genetic structure by the principal component analysis, the clustering of STRUCTURE program and a Neighbor-Joining tree, and then evaluated the genetic relationships among Tujia and other 15 populations.

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Section: Resultssupporting

confidence: 59%

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Shen

Zhu

Yao

et al. 2016

Sci Rep

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“…As a typical example of the apparent genetic affinity between the Gelao and all compared Han populations derived from distinct administrative regions as shown by all three phylogenetic methods, it can also be explained as a mixed cluster pattern: an obvious ethnical cluster of different Han populations coupled with a probable geographical cluster of the Gelao ethnicity and local Han majority, since they have a long history of living and intermarriage with each other in the same northern part of Guizhou Province 36 , 37 , 69 , 70 . Additionally, Guizhou Miao is another minority group in Guizhou Province and geographically close to Guizhou Gelao 60 .…”

Section: Discussionmentioning

confidence: 87%

Genetic structure and polymorphisms of Gelao ethnicity residing in southwest china revealed by X-chromosomal genetic markers

Chen

Zou

et al. 2018

Sci Rep

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X-chromosome short tandem repeat markers (X-STRs), due to their special inheritance models, physical location on a single chromosome and the absence of recombination in male meiosis, play an important role in forensic and population genetics. While a series of genetic analyses focusing on the genetic diversity and forensic characteristics of X-STRs are well studied for ethnically/linguistically diverse and demographically large Chinese populations, genetic evidence from Gelao ethnicity is still sparse. Here, we genotyped the first batch of 19 X-STRs in 513 Chinese Gelao individuals (265 females and 248 males), and reported genetic polymorphisms, forensic characteristics based on the single locus and seven linkage groups. DXS10135 with the highest PIC (0.9106) and LG1 (DXS10148-DXS10135-DXS8378) with the largest HD (0.9970) are polymorphic and informative. The CPDs in Gelao males and females are respectively larger than 0.999999999997095 and 0.99999999999999999999918, and the combined MECs are larger than 0.999999975715109. Subsequently, we investigated the population relationships among 14 Chinese populations based on 19 X-STRs and among 23 populations based on 11 overlapped X-STRs. Our results revealed genetic differentiations among Tibeto-Burman, Altaic and other Chinese homogenous populations, and demonstrated that Guizhou Gelao has the genetically closer relationships with Han Chinese and geographically close Guizhou Miao.

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“…To construct a paternal and maternal genealogy of HNL, we classified NRY haplogroups using Y-LineageTracker v1.3.0 ( Chen et al 2021 ) based on the ISOGG Y-DNA tree v2019-2020 ( https://isogg.org/tree ), and mtDNA haplogroups using HaploGrep v2.1.16 ( Weissensteiner et al 2016 ) based on a PhyloTree mtDNA tree v17 ( https://www.phylotree.org/tree ; Van Oven 2015 ). To investigate the population structure at paternal and maternal levels more comprehensively, we also collected NRY and mtDNA haplogroup data of East Asian and Southeast Asian populations from published research ( Kong et al 2003 ; Wen et al 2005 ; Hammer et al 2006 ; Hill et al 2007 ; Li, Cai, et al 2007 ; Li, Zhong, et al 2007 ; Jin et al 2009 ; Li et al 2010 ; Zhao et al 2010 ; Delfin et al 2012 , 2014 ; Ko et al 2014 ; Trejaut et al 2014 ; 1000 Genomes Project Consortium 2015 ; Lu et al 2016 ; Poznik et al 2016 ; Song et al 2019 ; Gao et al 2020 ; He et al 2020 ; Ma et al 2021 ) for comparison ( supplementary tables S4 and S5, Supplementary Material online) and performed PCA based on haplogroup frequency. We also calculated the haplogroup diversity for each population following the formula:

, where n is the sample size of each population and x is the frequency of each haplogroup in each population.…”

Section: Methodsmentioning

confidence: 99%

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Chen

Lin

Lü

et al. 2022

Molecular Biology and Evolution

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As the most prevalent aboriginal group on Hainan Island located between South China and the mainland of Southeast Asia, the Li people are believed to preserve some unique genetic information due to their isolated circumstances, although this has been largely uninvestigated. We performed the first whole-genome sequencing of 55 Hainan Li (HNL) individuals with high coverage (∼30–50×) to gain insight into their genetic history and potential adaptations. We identified the ancestry enriched in HNL (∼85%) is well-preserved in present-day Tai-Kadai speakers residing in South China and North Vietnam, i.e., Bai-Yue populations. A lack of admixture signature due to the geographical restriction exacerbated the bottleneck in the present-day HNL. The genetic divergence among Bai-Yue populations began ∼4,000–3,000 years ago when the proto-HNL underwent migration and the settling of Hainan Island. Finally, we identified signatures of positive selection in the HNL, some outstanding examples included FADS1 and FADS2 related to a diet rich in polyunsaturated fatty acids. In addition, we observed that malaria-driven selection had occurred in the HNL, with population-specific variants of malaria-related genes (e.g., CR1) present. Interestingly, HNL harbors a high prevalence of malaria leveraged gene variants related to hematopoietic function (e.g., CD3G) that may explain the high incidence of blood disorders such as B cell lymphomas in the present-day HNL. The results have advanced our understanding of the genetic history of the Bai-Yue populations and have provided new insights into the adaptive scenarios of the Li people.

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Genetic Polymorphism of Mitochondrial DNA in Dong, Gelao, Tujia, and Yi Ethnic Populations from Guizhou, China

Cited by 10 publications

References 15 publications

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

A 30-InDel Assay for Genetic Variation and Population Structure Analysis of Chinese Tujia Group

Genetic structure and polymorphisms of Gelao ethnicity residing in southwest china revealed by X-chromosomal genetic markers

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

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