Genetic polymorphism of interleukin-16 influences susceptibility to HBV-related hepatocellular carcinoma in a Chinese population

Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis

“…Li (Li et al, 2011) indicated that the rs11556218T/G TG and GG genotypes were not associated with risk of HBVrelated HCC compared the healthy controls, while there were significant association versus chronic hepatitis B patients. This is the only negative result among all eligible studies.…”

“…The study of Gao et al (2009b) presented separate OR by colorectal and gastric two cancer types and each of them was considered as a separate study. Finally, eight case-control studies from DOI:http://dx.doi.org/10.7314/APJCP.2014.15.11.4697 Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis seven publications (6 in English, 1 in Chinese) involving 3944 cases were finally included into the meta-analysis (Gao et al, 2009a;2009b, Zhu et al, 2010Azimzadeh et al, 2011;Li et al, 2011;Zhao et al, 2012;Qin et al, 2014). The main characteristics of the studies are listed in Table 1.…”

“…The main characteristics of the studies are listed in Table 1. Among these publications, only one study on Iranian population (Azimzadeh et al, 2011) and the remaining six studies on Chinese population (Gao et al, 2009a;2009b;Zhu et al, 2010;Li et al, 2011;Zhao et al, 2012;Qin et al, 2014). Eight eligible case-control studies associated with rs4778889 T/C polymorphism, seven for rs11556218 T/G polymorphism, and six for rs4072111 C/T polymorphism.…”

“…Eight eligible case-control studies associated with rs4778889 T/C polymorphism, seven for rs11556218 T/G polymorphism, and six for rs4072111 C/T polymorphism. The studies focused on the following cancer types: 2 studies investigated colorectal carcinoma (Gao et al, 2009b;Azimzadeh et al, 2011), 2 nasopharyngeal carcinoma (Gao et al, 2009a;Qin et al, 2014), 1 gastric cancer (Gao et al, 2009b), 1 hepatocellular carcinoma (Li et al, 2011), 1 renal cell carcinoma (Zhu et al, 2010) and 1 cervical cancer (Zhao et al, 2012). All of the study designs were hospital based (HB) and used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) genotyping method.…”

Non-Association of IL-16 rs4778889 T/C Polymorphism with Cancer Risk in Asians: a Meta-analysis

“…Numerous studies have investigated the potential association of IL-16 rs4778889 T/C polymorphism and cancer risk Zhu et al, 2010;Azimzadeh et al, 2011;Li et al, 2011). However, a single study might have been underpowered to detect the overall effects, and the genetic epidemiological studies into cancer risk are conflicting.…”