Genetic polymorphism of glutathione S-transferases M1 and T1 in Egyptian patients with bilharzial bladder cancer

Hameed, Amal H. Abd El; Negm, Osama El Sayed; El‐Gamal, Osama M.; Hamouda, Hala; Nouby, Kholoud A. El; Ismail, Ghada M.

doi:10.1016/j.urolonc.2008.09.015

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…For instance, glutathione S-transferase gene deletions were shown to be significantly more common in patients with S. hematobium -associated squamous cell carcinomas of the bladder [31]. Similarly, a specific arylamine N-acetyl transferase genotype was found to be more prevalent in patients with S. hematobium -associated squamous cell carcinoma of the bladder [32].…”

Section: Schistosoma Japonicummentioning

confidence: 99%

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Peterson

Weidner

2011

Journal of Tropical Medicine

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Several parasitic species are well known to have carcinogenic properties, namely; Schistosoma hematobium (squamous cell carcinoma of the bladder) and the liver flukes Opisthorchis and Chlonorchis (cholangiocarcinoma). A large number of parasites are known to colonize the gastrointestinal tract. We sought to review the evidence that implicates these parasites in gastrointestinal neoplasia. Schistosoma japonicum, which is endemic primarily in east Asia, has been shown in multiple studies to convey a mildly increased risk of colorectal adenocarcinoma. The data supporting a causative role for Schistosoma mansoni in colorectal or other neoplastic processes are less convincing, limited primarily to small case-control studies and case series. Reports of possible associations between other gastrointestinal parasites (e.g., E. histolytica and A. lumbricoides) and neoplasia may be found in the literature but are limited to individual cases. We conclude that, other than S. japonicum and to a lesser extent S. mansoni, there is little evidence of an association between gastrointestinal parasites and neoplasia.

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Section: Schistosoma Japonicummentioning

confidence: 99%

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Peterson

Weidner

2011

Journal of Tropical Medicine

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Polymorphisms of glutathione S-transferase μ and θ, MDR1 and VEGF genes as risk factors of bladder cancer: A case-control study

Henríquez-Hernández

Navarro

Luzardo

et al. 2012

Urologic Oncology: Seminars and Original Investigations

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Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility

Zhou

Xie

et al. 2018

BMC Cancer

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BackgroundWe conducted a meta-analysis to evaluate the relationship between the glutathione S-transferase μ1 (GSTM1)– and glutathione S-transferase θ1 (GSTT1)– null genotypes and susceptibility to bladder cancer.MethodsWe identified association reports from the databases of PubMed, Embase, the Cochrane Library and the China Biological Medicine Database (CBM disc) on July 1, 2017 and synthesized eligible investigations. Results were expressed using odds ratios (ORs) for dichotomous data, and we also calculated 95% confidence intervals (CIs).ResultsIn this meta-analysis, we found that the GSTM1-null genotype was associated with bladder cancer risk in the overall population, and individually in whites, Africans and Asians (overall population: OR = 1.40, 95% CI: 1.31–1.48, P<0.00001; whites: OR = 1.39, 95% CI: 1.26–1.54, P<0.00001; Africans: OR = 1.54, 95% CI: 1.16–2.05, P = 0.003; Asians: OR = 1.45, 95% CI: 1.33–1.59, P<0.00001). The GSTT1-null genotype was associated with bladder cancer risk in the overall population, but not in whites, in Africans or Asians (overall population: OR = 1.11, 95% CI: 1.01–1.22, P = 0.03; whites: OR = 1.16, 95% CI: 0.99–1.36, P = 0.07; Africans: OR = 1.07, 95% CI: 0.65–1.76, P = 0.79; Asians: OR = 1.05, 95% CI: 0.91–1.22, P = 0.51). Interestingly, a dual-null GSTM1–GSTT1 genotype was associated with bladder cancer risk in the overall population and in Asians (overall population: OR = 1.48, 95% CI: 1.15–1.92, P = 0.002; Asians: OR = 1.62, 95% CI: 1.15–2.28, P = 0.006). In conclusion, the GSTM1-null, GSTT1-null and dual-null GSTM1–GSTT1 genotypes might be associated with the onset of bladder cancer, but additional genetic-epidemiological studies should be conducted to explore this association further.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-5014-1) contains supplementary material, which is available to authorized users.

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Genetic polymorphism of glutathione S-transferases M1 and T1 in Egyptian patients with bilharzial bladder cancer

Cited by 4 publications

References 28 publications

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Polymorphisms of glutathione S-transferase μ and θ, MDR1 and VEGF genes as risk factors of bladder cancer: A case-control study

Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility

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