Genetic Polymorphism of Epidermal Growth Factor rs4444903 Influences Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma in a Chinese Han Population:

Zhang, Shitian; Qiao, Kunyan; Trieu, Congdoanh; Huo, Zhixiao; Dai, Qinghai; Du, Yanan; Lü, Wei; Hou, Wei

doi:10.7754/clin.lab.2016.161203

Cited by 9 publications

(9 citation statements)

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“…The risk of development from chronic hepatitis C (CHC) to HCC involves a complex interplay between the viral and host genetic factors 3. Our previous study4 together with others’ have revealed that host gene polymorphisms may play important roles in the development and progression of HCV-related HCC.…”

Section: Introductionmentioning

confidence: 94%

Association of IFNL3 rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population

Hou¹,

Qiao²,

Huo³

et al. 2019

CEG

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BackgroundThe association between interferon lambda-3 (IFNL3，also known as interleukin 28B, IL28B) rs12979860 polymorphism and the development of hepatocellular carcinoma (HCC) has been investigated in recent studies with inconclusive and inconsistent results. IFNL3 rs12979860 polymorphism has been shown a marked differential distribution with regional and ethnic variation. Whether this single nucleotide polymorphism influences susceptibility to hepatitis C virus (HCV)-related HCC remains elusive.MethodsIn this case–control study, a total of 157 Chinese Han patients with chronic HCV infection were enrolled, including 62 HCV-related HCC patients and 95 chronic hepatitis C (CHC) patients without HCC, and the genetic polymorphism of IFNL3 rs12979860 was genotyped via a DNA microarray-based assay. The logistic regression analysis was employed to determine the correlation between the genetic polymorphism and risk of HCV-related HCC.ResultsA higher proportion of CT/TT genotype and T allele was observed in HCC patients compared to the CHC group. Under the genetic model of allele frequency, the T allele was associated with elevated risk of HCV-related HCC in the Chinese population compared to C allele after an adjustment for age, gender, body mass index, HCV infection duration, and HCV genotypes (P=0.046). In the subgroup analysis stratified by HCV genotype, subjects with CHC genotype 1b infection carrying rs12979860 T allele and CT+TT genotype had higher susceptibility to HCC than those with C allele and CC genotype (P=0.020, P=0.037, respectively).ConclusionIFNL3 rs12979860 polymorphism with T allele could be a factor that increases the risk of HCV-related HCC in the Chinese population, especially those subjects with CHC genotype 1b infection.

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Section: Introductionmentioning

confidence: 94%

Association of IFNL3 rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population

Hou¹,

Qiao²,

Huo³

et al. 2019

CEG

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“…Previous studies also suggested a possible role of MTHFR rs1801133 in HCC progression, but further research showed conflicting results. This includes two recent meta-analyses, one of which confirmed the association, while the other rejected it, with the exception of the Asian subpopulation [ 9 , 11 , 37 ]. Recently, Pineda-Tenor et al [ 38 ] reported that MTHFR rs1801133 polymorphism is associated with the progression of liver fibrosis in chronic hepatitis C. However, we found no association between the MTHFR polymorphism and susceptibility to ALC or HCC.…”

Section: Discussionmentioning

confidence: 99%

NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms

Bainrauch

Šisl

Markotić

et al. 2021

JCM

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Alcoholic liver cirrhosis (ALC) is the most common indication for liver transplantation (LT) in Croatia and presents a risk factor for the development of hepatocellular carcinoma (HCC). However, genetic susceptibility has not yet been systematically studied. We aimed to investigate the contribution of the risk polymorphisms PNPLA3 rs738409, EGF rs4444903, TM6SF2 rs58542926, MTHFR rs1801133, previously identified in other populations and, additionally, the contribution of Notch-related polymorphisms (NOTCH1 rs3124591, NOTCH3 rs1043996 and rs1044116, NOTCH4 rs422951). The study included 401 patients. The ALC group consisted of 260 LT candidates, 128 of whom had histopathologically confirmed HCC, and 132 of whom were without HCC. The control group included 141 patients without liver disease. Genotyping was performed by PCR using Taqman assays. The patients’ susceptibility to ALC was significantly associated with PNPLA3 rs738409, TM6SF2 rs58542926, and NOTCH3 rs1043996 polymorphisms. These polymorphisms remained significantly associated with ALC occurrence in a logistic regression model, even after additional model adjustment for sex and age. Cirrhotic patients with the PNPLA3 GG genotype demonstrated higher activity of ALT aminotransferases than patients with CC or CG genotypes. The susceptibility to the development of HCC in ALC was significantly associated with PNPLA3 rs738409 and EGF rs4444903 polymorphisms, and logistic regression confirmed these polymorphisms as independent predictors.

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“…Seven articles were grouped into two or three studies because they contain two or three sources of controls [15,21,22,26,27,31] or two ethnicities [17,18]. Finally, 18 articles [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] were included in this meta-analysis. The selection process for eligible studies was presented in Fig.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The functional variation (G to A) identified by Shahbazi et al at position 61 (rs4444903 -61A > G) of 5'-UTR in the EGF gene is associated with EGF up-expression and risk of malignant melanoma [13]. Recently, a host of studies have attached importance to evaluating whether EGF rs4444903 polymorphism affects the risk of HBV/ HCV, liver cirrhosis and HCC, but with conflicting findings [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Therefore, we conducted this meta-analysis to review the available evidence and investigate the effects of EGF rs4444903 polymorphism on HCC susceptibility in the overall population.…”

Section: Introductionmentioning

confidence: 99%

EGF rs4444903 polymorphism is associated with risk of HCV-related cirrhosis and HBV/HCV-related hepatocellular carcinoma

2021

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Objective The epidermal growth factor (EGF) rs4444903 polymorphism is associated with aberrant expression of EGF, which was a characteristic of cirrhotic liver diseases, induces highly malignant hepatocellular carcinoma (HCC). Numerous studies have uncovered the association of this polymorphism with the risk of liver disease, but with inconsistent findings. Materials and methods Therefore, this meta-analysis was performed to evaluate whether EGF rs4444903 polymorphism conferred susceptibility to liver disease. Totally 18 eligible articles were identified by searching PubMed, Google, CNKI and EMBASE up to December 1, 2020. Results Our results indicated that there was no significant difference in the minor G allele frequency of rs4444903 polymorphism between HBV/HCV carriers and healthy controls. In other words, EGF rs4444903 polymorphism was not associated with the risk of HBV/HCV. Interestingly, this polymorphism increased the risk of liver cirrhosis in the controls with HCV infection. Additionally, EGF rs4444903 polymorphism is associated with the increased risk of HCC under the five models. Subgroup analysis by ethnicity shows that rs4444903 polymorphism intensifies the risk of HCC among Asians and Caucasians. Strong correlation is also reported in controls with cirrhosis or HCV infection and studies using PCR-RFLP genotyping. ConclusionsThe study supports that EGF rs4444903 polymorphism is a genetic contributor to liver cirrhosis and HCC in the overall population. Nevertheless, this conclusion must be confirmed by larger studies with more diverse ethnic populations.

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Genetic Polymorphism of Epidermal Growth Factor rs4444903 Influences Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma in a Chinese Han Population:

Abstract: The EGF rs4444903 GG genotype is associated with higher susceptibility to HCV-related LC and HCC in the Chinese Han population. Screening of host genetic polymorphisms might be helpful in designing effective and efficient LC and HCC surveillance programs for chronic HCV-infected patients.

Cited by 9 publications

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<p>Association of <em>IFNL3</em> rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population</p>

<p>Association of <em>IFNL3</em> rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population</p>

NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms

EGF rs4444903 polymorphism is associated with risk of HCV-related cirrhosis and HBV/HCV-related hepatocellular carcinoma

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