Genetic polymorphism of 22 autosomal STR markers in a Han population of Southern China

Liu, Qiuling; Chen, Zi-Xiang; Chen, Chu-Guang; Lu, Dalei

doi:10.1016/j.fsigen.2016.06.017

Cited by 18 publications

(6 citation statements)

References 23 publications

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“…In our study, 22 autosomal STR loci, including 18 non-CODIS loci and four CODIS loci, were utilized to assess their genetic distributions in the Kazakh group living in Xinjiang Uygur Autonomous Region. Significant deviations of LD among these 22 STR loci were detected in D10S1435-D15S659 and D13S325-D17S1290, which were not found in other similar studies based on Microreader™ 23sp ID kit (Fang et al, 2018; Liu et al, 2016). Moreover, the fairly small r 2 values of 22 STR pairs were conductive to determine the low correlations between these pairwise STRs.…”

Section: Discussioncontrasting

confidence: 70%

Forensic characteristics and population genetics of Chinese Kazakh ethnic minority with an efficient STR panel

Chen

Guo

Jin

et al. 2019

PeerJ

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On the purpose of enhancing the forensic efficiency of CODIS STR loci, new STR loci have been gradually discovered and developed into some commercial multiplex systems. Recently, 22 STR loci including 18 non-CODIS STR loci and four CODIS STR loci were investigated in 501 unrelated healthy individuals of Kazakh ethnic group. Seven to 20 alleles at the different loci were identified and altogether 276 alleles for 22 selected loci were detected with the corresponding allelic frequencies ranging from 0.0010 to 0.3623. No significant deviation was observed from the Hardy–Weinberg equilibrium test for any of the 22 STRs. The value of cumulative power of discrimination in Kazakh group was 1-1.00E−28. Analyses of population differentiations and genetic distances between Kazakh and other Chinese groups presented that the Kazakh group with the Uygur group. These 22 STR loci evenly distributed on 22 different autosomal chromosomes were characterized by high genetic diversities and therefore could be utilized in the forensic cases to further increase the discrimination performance.

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Section: Discussioncontrasting

confidence: 70%

Forensic characteristics and population genetics of Chinese Kazakh ethnic minority with an efficient STR panel

Chen

Guo

Jin

et al. 2019

PeerJ

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“…We assessed the differences between Xinjiang Mongolian population and six reference populations in the allele frequencies of these 22 loci by using the analysis of molecular variance (Table 2). There were significant differences at 6, 8, 6, 8, 9, and 17 loci between Mongolian population and Northern Han (Hebei, Henan, Shaanxi) (2), Guangdong Han (3), Chengdu Han (4), Xinjiang Hui (6), Xinjiang Uygur (7), and Hainan Li (5) populations, respectively. In addition, we chose 16 loci as overlapping loci (except for D2S1338, D9S925, D12S391, D16S539, D20S470, and D21S1270) to compare the studied population with the Qinghai Tibetan (26) and Hainan Han (27) populations.…”

Section: Resultsmentioning

confidence: 99%

“…This panel was validated by a previous study (1), which assessed its sensitivity, accuracy, precision, stability, stutter percentage, peak height ratio, and species specificity. It was used to analyze allelic distribution in Northern Han (2), Southern Han (3), Chengdu Han (4), Hainan Li (5), Xinjiang Hui (6), and Xinjiang Uygur (7). In addition, detailed sequence information of these 22 loci was studied by Phillips et al (8).…”

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confidence: 99%

Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel

et al. 2019

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Aim To determine allele frequencies and forensic statistics of 22 autosomal short tandem repeat loci in Chinese Mongolian population. Methods Blood specimens were collected from 134 unrelated healthy Mongolian individuals, and 22 short tandem repeat loci were co-amplified and genotyped. Allele frequencies and forensic parameters were calculated, and population genetic differences were analyzed among Mongolian population and other eight Chinese populations: Northern Han, Guangdong Han, Chengdu Han, Xinjiang Hui, Xinjiang Uygur, Hainan Li, Qinghai Tibetan, and Hainan Han. Results All the loci were in the Hardy-Weinberg equilibrium, and after Bonferroni correction there was no linkage disequilibrium between them. The allele frequencies of these 22 loci were between 0.0037 and 0.3657. This panel had high discriminating power and genetic polymorphism in the Mongolian population, with combined power of discrimination of 0.999999999999999999999999998399 and combined probability of exclusion of 0.9999999999566925. Structure analysis showed no evidence that these nine Chinese populations had different component distribution. However, genetic distance analysis showed significant differences among them ( P < 0.05). Conclusion The combined application of these 22 loci could be useful for forensic purposes in the Mongolian population. Mongolian population had smaller genetic distances from the populations in northern China (Northern Han, Xinjiang Uygur, and Xinjiang Hui) than from the populations in Hainan province (Hainan Han and Hainan Li populations).

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“…In total, Han in Eastern China at 21 STR loci [5], Tibetan at 21 STR loci [6], Han in Northern China at 18 STR loci [7], Uygur at 18 STR loci [8,9], Han in Western China at 17 STR loci [10,11], Han in Southern China at 17 STR loci [12,13], Han in Central China at 9 STR loci [14,15], Han in Southwest China at 7 STR loci [16], and Mongolian at 6 STR loci [17,18] differentiation of individuals and parentage testing. Additionally, the data of current investigation will also be beneficial for the development of a database of the Chinese Han population.…”

Section: Genetic Distribution Of 21 Str Loci In the Chinesementioning

confidence: 99%

Genetic distribution of 21 STR loci in the Chinese Han population from Hainan Island using Goldeneye™ DNA ID 22NC Kit

Guo

et al. 2017

Forensic Science International: Genetics

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Genetic polymorphism of 22 autosomal STR markers in a Han population of Southern China

Cited by 18 publications

References 23 publications

Forensic characteristics and population genetics of Chinese Kazakh ethnic minority with an efficient STR panel

Forensic characteristics and population genetics of Chinese Kazakh ethnic minority with an efficient STR panel

Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel

Genetic distribution of 21 STR loci in the Chinese Han population from Hainan Island using Goldeneye™ DNA ID 22NC Kit

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