Genetic polymorphism of 15 autosomal STR loci in population of Chhattisgarh, India

Ekka, Apolina; Kujur, Kuldeep; Sirmour, Ravindra; Guha, Debojit; Padhye, Sanchali A.; Verma, Anju; Dixit, Shivani; Kumawat, R. K.; Chaubey, Gyaneshwer; Shrivastava, Pankaj

doi:10.1016/j.genrep.2020.100883

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…So far, only a limited number of genetic studies on Y-STRs among the Central Indian population have been reported. Hence, there is a need to conduct more studies on this population [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Genetic Polymorphisms in the Rewa Population of Central India Using Y-Chromosomal STR Markers

Mishra¹,

Gondhali²,

Mishra³

et al. 2021

Sovrem Tehnol Med

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Section: Introductionmentioning

confidence: 99%

Assessment of Genetic Polymorphisms in the Rewa Population of Central India Using Y-Chromosomal STR Markers

Mishra¹,

Gondhali²,

Mishra³

et al. 2021

Sovrem Tehnol Med

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Evaluation and comparison of population genetics software in Rabari Tribe of Gujarat population

Mishra

Kumari

Choudhary

et al. 2021

Egypt J Forensic Sci

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Background Today, when forensic experts talk about quantifiable hereditary traits, they do not just depend on the assessment and examination of DNA profiles but also relate them to the population structures. The use of high-throughput molecular marker technologies and advanced statistical and software tools have improved the accuracy of human genetic diversity analysis in many populations with limited time and resources. The present study aimed to investigate the genomic diversity in Gujarat’s Rabari population, using 20 autosomal genetic markers. Numerous bio-statistical software programs are available for the interpretation of population data in forensics. These statistics deal with the measurement of uncertainty and also provides a probability of a random match. The present paper aims to provide a practical guide to the analysis of population genetics data. Three statistical software packages named Cervus, Genepop, and Fstat are compared and contrasted. The comparison is performed on the profiles obtained from fifty unrelated blood samples of healthy male individuals. DNA was extracted using the organic extraction method, 20 autosomal STR loci were amplified using PowerPlex 21 kit (Promega, Madison, WI, USA) and detected on 3100 Genetic Analyser (Life Technologies Corporation, Carlsbad, CA, USA). Results A total of 170 alleles were observed in the Rabari Tribe of Gujarat population, and allele frequencies ranged from 0.010 to 0.480. The highest allele frequency detected was 0.480 for allele 9 at locus TH01. Based on heterozygosity and the polymorphism information content, FGA may be considered as the most informative markers. Both the combined power of discrimination (CPD) and the combined power of exclusion (CPE) for the 20 analyzed loci were higher than 0.999999. The combined match probability (CPM) for all 20 loci was 2.5 × 10−22. Conclusions With respect to the results, the 20 STR loci are highly polymorphic and discriminating in the Gujarat population and could be used for forensic practice and population genetics studies. However, Fstat demonstrated better genetic software for analysis of the demographic structure of a specific or set of populations.

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Genetic polymorphism of 15 autosomal STR loci in population of Chhattisgarh, India

Cited by 2 publications

References 16 publications

Assessment of Genetic Polymorphisms in the Rewa Population of Central India Using Y-Chromosomal STR Markers

Assessment of Genetic Polymorphisms in the Rewa Population of Central India Using Y-Chromosomal STR Markers

Evaluation and comparison of population genetics software in Rabari Tribe of Gujarat population

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