Genetic polymorphism of 13 non‐CODIS STR loci in three national populations from China

Liu, Qiuling; Huang, Kaikai; Wu, Yeda; Zhao, Hu; Li, Chengtao; Lu, Dalei

doi:10.1002/elps.201400290

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…The genomic information of these loci is presented in Table . STR typing was performed using the method that has been previously established .…”

Section: Methodsmentioning

confidence: 99%

“…But few closely linked STR markers have been assessed for kinship analysis except for the loci available in commercial STR kits (such as vWA‐D12S391 , D5S818‐CSF1PO, D21S11‐Penta D , and other loci ). Therefore, a multiplex PCR systems with the simultaneous analysis of 13 autosomal STR (AS‐STR) markers including the six clusters of closely linked markers (clusterⅠ: D3S2402‐D3S2452‐D3S1766; Ⅱ: D3S4554‐D3S2388; Ⅲ: D3S3051‐D3S3053; Ⅳ: D4S2364‐D4S2404; Ⅴ: AC001348A‐AC001348B; Ⅵ:D17S975‐D17S1294) was developed to generalize the application of closely linked AS‐STR in forensics . In this study, we will evaluate the effect of this set of linked STRs for kinship analysis.…”

Section: Introductionmentioning

confidence: 99%

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Potential of 13 linked autosomal short tandem repeat loci in pairwise kinship analysis

Liu

Xue

et al. 2016

Electrophoresis

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In this study, a panel of 13 STR loci locate on chromosome 3, 4, and 17 (D3S2402, D3S2452, D3S1766, D3S4554, D3S2388, D3S3051, D3S3053, D4S2404, D4S2364, AC001348A, AC001348B, D17S975, and D17S1294) were assessed for pairwise kinship analysis. Map distances between these STR loci ranged from 0.07 cM to 97.03 cM. The population genetic study of Chinese Han population showed that linkage disequilibrium exists in two clusters of closely linked markers (D4S2404-D4S2364 and D17S975-D17S1294), in which the recombination fractions were 0.0026 and 0.0001, respectively. The recombination fractions derived from the Rutgers Map for the closely linked markers (genetic distance < 0.5 cM) were significant underestimates in comparison to those of direct observation of STR transmissions in families. When effect of linkage on pairwise kinship testing was evaluated by comparing likelihood ratio (LR) values taking linkage into account, overall LR values increased. But extremely low LRs were also observed. Finally, the power of the 13 STR loci to discriminate relationship among full-sibs, half-sibs, grandparent-grandchild, uncle-niece, and unrelated pairs was assessed with a category fraction. The results showed that about 72.64% of full-sib pairs and about 82.84% of unrelated pairs could be classified correctly. But the category fractions of second-degree relationships drastically reduced to 7.34-35.48%. If only pairs of grandparent-grandchild, half-sibs, and uncle-niece were distinguished, the category fraction was 0.5512, 0.1147, and 0.4362, respectively. Our study results demonstrated that linked STRs were helpful to differentiate the most frequent relationships in pairwise kinship analysis.

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“…The genomic information of these loci is presented in Table . STR typing was performed using the method that has been previously established .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential of 13 linked autosomal short tandem repeat loci in pairwise kinship analysis

Liu

Xue

et al. 2016

Electrophoresis

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“…Genomic details of novel autosomal STRs, developed in published multiplexes for CE genotyping[15,[21][22][23][24][25], but not in commercially available kits.…”

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confidence: 99%

A genomic audit of newly-adopted autosomal STRs for forensic identification

Phillips

2017

Forensic Science International: Genetics

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In preparation for the growing use of massively parallel sequencing (MPS) technology to genotype forensic STRs, a comprehensive genomic audit of 73 STRs was made in 2016 [Parson et al., Forensic Sci. Int. Genet. 22, 54-63]. The loci examined included miniSTRs that were not in widespread use, but had been incorporated into MPS kits or were under consideration for this purpose. The current study expands the genomic analysis of autosomal STRs that are not commonly used, to include the full set of developed miniSTRs and an additional 24 STRs, most of which have been recently included in several supplementary forensic multiplex kits for capillary electrophoresis. The genomic audit of these 47 newly-adopted STRs examined the linkage status of new loci on the same chromosome as established forensic STRs; analyzed world-wide population variation of the newly-adopted STRs using published data; assessed their forensic informativeness; and compiled the sequence characteristics, repeat structures and flanking regions of each STR. A further 44 autosomal STRs developed for forensic analyses but not incorporated into commercial kits, are also briefly described.

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Population data of 13 nonCODIS STR markers located inside the 6 nonsyndromic oculocutaneous albinism genes

Deilamani

Akbari

2016

Int J Legal Med

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Allele frequencies and forensic statistics of 13 autosomal short tandem repeat loci were estimated in 56 unrelated Iranian individuals. Except for two loci which were monomorph, a total of 5-11 alleles at each locus were observed and altogether 94 alleles for all selected loci were found. Our results show that 11 out of 13 nonCODIS STR loci are polymorphic and can be useful for human identification and kinship analysis and relationship investigations in Iran.

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Genetic polymorphism of 13 non‐CODIS STR loci in three national populations from China

Cited by 5 publications

References 18 publications

Potential of 13 linked autosomal short tandem repeat loci in pairwise kinship analysis

Potential of 13 linked autosomal short tandem repeat loci in pairwise kinship analysis

A genomic audit of newly-adopted autosomal STRs for forensic identification

Population data of 13 nonCODIS STR markers located inside the 6 nonsyndromic oculocutaneous albinism genes

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