Genetic pathways in cerebral palsy: a review of the implications for precision diagnosis and understanding disease mechanisms

Xu, Yiran; Li, Yifei; Richard, Seidu A.; Sun, Yanyan; Zhu, Changlian

doi:10.4103/1673-5374.385855

Cited by 3 publications

(1 citation statement)

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“…NDI was characterized by the presence of one or more of the following conditions among the survivors: cerebral palsy (CP), MDI < 70, hearing loss, and blindness. Cerebral palsy was defined as a group of non-progressive impairments affecting the development of movement and posture, and any type and severity of CP were involved in our study ( 19 ). The MDI was based on the Bayley Scales of Infant Development II, with a score below 70 indicating severe impairment of neurodevelopment ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

Association between bronchopulmonary dysplasia and death or neurodevelopmental impairment at 3 years in preterm infants without severe brain injury

Li,

Wang,

Song

et al. 2023

Front. Neurol.

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ObjectiveWe investigated the association between bronchopulmonary dysplasia (BPD) and 3 years death or neurodevelopmental impairment (NDI) in very preterm infants without severe brain injury.MethodOur prospective cohort study recruited preterm infants who were born prior to 32 weeks of gestational age and survived in the neonatal intensive care unit until 36 weeks of corrected age. Upon reaching 3 years of age, each infant was assessed for death or NDI such as cerebral palsy, cognitive deficit, hearing loss, and blindness. Correlations between BPD and death or NDI were determined using multiple logistic regression analyses adjusted for confounding factors.ResultA total of 1,417 infants without severe brain injury who survived until 36 weeks of corrected age were initially enrolled in the study. Over the study period, 201 infants were lost to follow-up and 5 infants were excluded. Our final dataset, therefore, included 1,211 infants, of which 17 died after 36 weeks of corrected age and 1,194 were followed up to 3 years of age. Among these infants, 337 (27.8%) developed BPD. Interestingly, by 3 years of age, BPD was demonstrated to be independently associated with death or NDI, with an adjusted odds ratio of 1.935 (95% confidence interval: 1.292–2.899, p = 0.001), in preterm infants without severe neonatal brain injury.ConclusionOur findings indicate that BPD is strongly associated with death or NDI in preterm infants without severe neonatal brain injury at 3 years of age. Further research is needed to understand the mechanisms linking the development of BPD with death or NDI and whether appropriate treatment of BPD may ameliorate or prevent the development of neurological complications.

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Section: Methodsmentioning

confidence: 99%