Genetic, pathogenic and antigenic diversity of Newcastle disease viruses in Shandong Province, China

Huang, Yanyan; ShaoHua, Yang; BeiXia, Hu; Xu, Chunyan; Gao, Dandan; Zhu, Manling; Huang, Qinghua; Zhang, Lin; Wu, Jiaqiang; Zhang, Xiumei; Khan, Marzhar I.

doi:10.1016/j.vetmic.2015.09.002

Cited by 16 publications

(14 citation statements)

References 35 publications

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“…Most prevalent virulent genotype VII causing the endemics in China, Japan, Korea [18,60,65] are co circulating into the ducks and chicken [66]. This coevolution was further confirmed when the results of Huang et al [67] declared that some of the circulating APMV-1 had the multiple homologous genomes from chicken, ducks and geese. So, there is dire need to modernize the housing system of waterfowl according to biosecurity point of view to prevent their contact with terrestrial poultry and wild birds.…”

Section: Role Of Waterfowls In Emergence Of Apmv-1mentioning

confidence: 80%

Pathobiology of Avian avulavirus 1: special focus on waterfowl

Rehman¹,

Chen²,

Sun³

et al. 2018

Vet Res

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Avian avulaviruses serotype 1 (abbreviated as APMV-1 for the historical name avian paramyxovirus 1) are capable of infecting a wide spectrum of avian species with variable clinical symptoms and outcomes. Ease of transmission has allowed the virus to spread worldwide with varying degrees of virulence depending upon the virus strain and host species. The emergence of new virulent genotypes from global epizootics, and the year-to-year genomic changes in low and high virulence APMV-1 imply that distinct genotypes of APMV-1 are simultaneously evolving at different geographic locations across the globe. This vast genomic diversity may be favoured by large variety of avian species susceptibility to APMV-1 infection, and by the availability of highly mobile wild birds. It has long been considered that waterfowls are not sensitive to APMV-1 and are unable to show any clinical signs, however, outbreaks from the 90′s contradict these concepts. The APMV-1 isolates are increasingly reported from the waterfowl. Waterfowl have strong innate immune responses, which minimize the impact of virus infection, however, are unable to prevent the viral shedding. Numerous APMV-1 are carried by domestic waterfowl intermingling with terrestrial poultry. Therefore, commercial ducks and geese should be vaccinated against APMV-1 to minimize the virus shedding and for the prevention the transmission. Genetic diversity within APMV-1 demonstrates the need for continual monitoring of viral evolution and periodic updates of vaccine seed-strains to achieve efficient control and eradication of APMV-1 in waterfowls.Electronic supplementary materialThe online version of this article (10.1186/s13567-018-0587-x) contains supplementary material, which is available to authorized users.

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Section: Role Of Waterfowls In Emergence Of Apmv-1mentioning

confidence: 80%

Pathobiology of Avian avulavirus 1: special focus on waterfowl

Rehman¹,

Chen²,

Sun³

et al. 2018

Vet Res

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“…The majority of ND outbreaks have been attributed to class II viruses. Epidemiological data have revealed that NDV strains in the VII genotype were the predominant epidemic strains associated with a large number of ND outbreaks in China, leading to numerous economic losses in the poultry industry (Huang et al, ; Rui et al, ; Zhu et al, ). It has been found that NDV can infect at least 250 bird species and has a worldwide distribution (Kaleta & Baldauf, ).…”

Section: Introductionmentioning

confidence: 99%

Phylogeny, pathogenicity and transmissibility of a genotype XII Newcastle disease virus in chicken and goose

Xiang

Chen

Liang

et al. 2019

Transbound Emerg Dis

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Although Newcastle disease virus (NDV) has a worldwide distribution, some NDV genotypes have more regional geographical ranges within continents. In this study, we isolated a subgenotype XIIb NDV strain, Goose/CH/GD/E115/2017 (E115), from geese in Guangdong province, Southern China, in 2017. Phylogenetic analysis showed that E115 and six other NDVs from geese in China were grouped under subgenotype XIIb and were distinct from subgenotype XIIa, isolated from chickens in South Africa, and subgenotype XIId, isolated from chickens in Vietnam. To better understand the pathogenicity and transmission of the subgenotype XIIb NDVs from geese in Guangdong province, we inoculated chickens and geese with 106 EID50 of the E115 virus. Eight hours after inoculation, three naïve chickens and three naïve geese were co‐housed with the infected chickens or geese to assess intraspecific and interspecific horizontal transmission of the E115 virus. The E115 virus induced significant clinical signs without mortality in chickens, while it was not pathogenic to geese. Intraspecific and interspecific horizontal transmission of the E115 virus was observed among chickens and geese via direct contact. Furthermore, although the current vaccines provided complete protection against disease in chickens after challenging them with the E115 virus, the virus could also be transmitted from vaccinated chickens to naïve contact chickens. Collectively, our findings highlight the need for avoiding the mixing of different bird species to reduce cross‐species transmission and for surveillance of NDV in waterfowl.

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“…Class I includes two genotypes, and class II includes 18 genotypes [26]. The LaSota strain, belonging to genotype II of class II, has been commonly used as a live-virus NDV vaccine strain since the 1950s [27], but several studies have reported that using LaSota vaccine to immunize chickens could provide cross-protection against other genotypes of NDV, such as VIb, VIg, VIId, XVII and IX [28][29][30]. In the present study, the recombinant vaccine expressing LaSota HN protein displayed 80 % protective efficacy against challenge with NDV F48E9 (IX genotype), in contrast to 90 % protective efficacy in this study and 100 % protective efficacy reported by Liu et al induced by LaSota live vaccine [28].…”

Section: Discussionmentioning

confidence: 99%

Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge

Yang¹,

Zhou

Li³

et al. 2016

Arch Virol

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Infectious bronchitis (IB) and Newcastle disease (ND) are common viral diseases of chickens, which are caused by infectious bronchitis virus (IBV) and Newcastle disease virus (NDV), respectively. Vaccination with live attenuated strains of IBV-H120 and NDV-LaSota are important for the control of IB and ND. However, conventional live attenuated vaccines are expensive and result in the inability to differentiate between infected and vaccinated chickens. Therefore, there is an urgent need to develop new efficacious vaccines. In this study, using a previously established reverse genetics system, we generated a recombinant IBV virus based on the IBV H120 vaccine strain expressing the haemagglutinin-neuraminidase (HN) protein of NDV. The recombinant virus, R-H120-HN/5a, exhibited growth dynamics, pathogenicity and viral titers that were similar to those of the parental IBV H120, but it had acquired hemagglutination activity from NDV. Vaccination of SPF chickens with the R-H120-HN/5a virus induced a humoral response at a level comparable to that of the LaSota/H120 commercial bivalent vaccine and provided significant protection against challenge with virulent IBV and NDV. In summary, the results of this study indicate that the IBV H120 strain could serve as an effective tool for designing vaccines against IB and other infectious diseases, and the generation of IBV R-H120-HN/5a provides a solid foundation for the development of an effective bivalent vaccine against IBV and NDV.

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Genetic, pathogenic and antigenic diversity of Newcastle disease viruses in Shandong Province, China

Cited by 16 publications

References 35 publications

Pathobiology of Avian avulavirus 1: special focus on waterfowl

Pathobiology of Avian avulavirus 1: special focus on waterfowl

Phylogeny, pathogenicity and transmissibility of a genotype XII Newcastle disease virus in chicken and goose

Recombinant infectious bronchitis virus (IBV) H120 vaccine strain expressing the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) protects chickens against IBV and NDV challenge

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