Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3β

Barbisan, Fernanda; Azzolin, Verônica Farina; Monteiro, G.; Teixeira, Cibele Ferreira; Mastella, Moisés Henrique; Bueno, Vitor; Wagner, Glauber; Prado-Lima, Pedro Antônio Schmidt do; Ribeiro, Euler Esteves; Cruz, Ivana Beatrice Mânica da

doi:10.1016/j.gene.2018.02.046

Cited by 19 publications

(5 citation statements)

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“…Likewise, açai was able to reverse the inflammatory activation of macrophages [49] and microglia [50]. Other studies have also shown that the inflammatory pattern associated with the VV-SOD2 genotype was attenuated in vitro by supplementing cell cultures with lithium [51]. On the other hand, genetic variations leading to mitochondrial dysfunction could also contribute to the risk of mood disorders [52 -54].…”

Section: Discussionmentioning

confidence: 99%

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

et al. 2022

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“…The range evaluated for OLZ was 0.02 μg/mL to 0.08 μg/mL according to guidelines of drug therapeutic monitoring [39]. The therapeutic Li concentration used was 0.07 mEq/L, which has been previously evaluated in vitro [21,22]. Therefore, results of this study may be representative of interactive in vivo effects between OLZ and Li.…”

Section: Discussionmentioning

confidence: 99%

“…All protocols performed were similar to previously described studies by Barbisan et al [22] and Duarte et al [23] of in vitro psychotropic drug effects on macrophage inflammatory response. Macrophages are highly sensitive to antigens and other antigenic factors, which induce intense cellular proliferation and morphological changes.…”

Section: Methodsmentioning

confidence: 99%

Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells

et al. 2019

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BackgroundOlanzapine (OLZ) is a second-generation antipsychotic drug used for treatment of schizophrenia, bipolar disorder, and other neuropsychiatric conditions. Undesirable side effects of OLZ include metabolic alterations associated with chronic oxidative-inflammation events. It is possible that lithium (Li), a mood modulator that exhibits anti-inflammatory properties may attenuate OLZ-induced oxi-inflammatory effects.MethodologyTo test this hypothesis we activated RAW 264.7 immortalized macrophages with OLZ and evaluated oxidation and inflammation at the gene and protein levels. Li and OLZ concentrations were determined using estimated plasma therapeutic concentrations.ResultsOLZ triggered a significant increase in macrophage proliferation at 72 h. Higher levels of oxidative markers and proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6, with a concomitant reduction in IL-10, were observed in OLZ-exposed macrophages. Lithium (Li) exposure triggered a short and attenuated inflammatory response demonstrated by elevation of superoxide anion (SA), reactive oxygen species (ROS), IL-1β, and cellular proliferation followed by elevation of anti-inflammatory IL-10 levels. Li treatment of OLZ-supplemented macrophages was able to reverse elevation of oxidative and inflammatory markers and increase IL-10 levels.ConclusionsDespite methodological limitations related to in vitro protocols, results suggested that Li may attenuate OLZ-induced oxidative and inflammatory responses that result from metabolic side effects associated with OLZ.

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“…Similarly, low brain Nrf2 expression occurs in hypogonadal 21-month-old male rats, an effect countered by low dose T administration (Zhang et al, 2016;Cui et al, 2017), while chemical castration of rats lowers testicular Nrf2 protein expression (Bae et al, 2017). Because excess oxidative stress itself increases GSK3β protein expression (Shin et al, 2006;Barbisan et al, 2018), excess oxidative stress may act in a feed-forward manner to increase GSK3β activity, inhibit Nrf2 activity, and further increase oxidative stress. GSK3β also upregulates Aβ production (Ryder et al, 2003) and it increases tau hyperphosphorylation (Papasozomenos, 1997;Papasozomenos and Shanavas, 2002).…”

Section: Low Sex-steroid Hormone Levels Increase Activity Of Glycogenmentioning

confidence: 99%

Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?

Kaufman

Kanayama

Hudson

et al. 2019

Neuroscience & Biobehavioral Reviews

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Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with physiologic, cognitive, and brain abnormalities similar to those found in people at risk for developing Alzheimer's Disease and its related dementias (AD/ADRD), which are associated with high brain β-amyloid (Aβ) and hyperphosphorylated tau (tau-P) protein levels. Supraphysiologic-dose AAS induces androgen abnormalities and excess oxidative stress, which have been linked to increased and decreased expression or activity of proteins that synthesize and eliminate, respectively, Aβ and tau-P. Aβ and tau-P accumulation may begin soon after initiating supraphysiologic-dose AAS use, which typically occurs in the early 20s, and their accumulation may be accelerated by other psychoactive substance use, which is common among non-medical AAS users. Accordingly, the widespread use of supraphysiologic-dose AAS may increase the numbers of people who develop dementia. Early diagnosis and correction of sex-steroid level abnormalities and excess oxidative stress could attenuate risk for developing AD/ADRD in supraphysiologic-dose AAS users, in people with other substance use disorders, and in people with low sex-steroid levels or excess oxidative stress associated with aging.

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Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3β

Cited by 19 publications

References 29 publications

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells

Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?

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