Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort

Chalazan, Brandon; Mol, Denise; Sridhar, Arvind; Alzahrani, Zain; Darbar, Sara D.; Ornelas-Loredo, Aylin; Farooqui, Abdullah; Argos, Maria; Daviglus, Martha L.; Konda, Sreenivas; Rehman, Jalees; Darbar, Dawood

doi:10.1371/journal.pone.0194480

Cited by 13 publications

(24 citation statements)

References 38 publications

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“…9 Inclusion criteria were age greater than 18 years with a documented history of AF by electrocardiogram (ECG). Consecutive patients attending the General Cardiology, Arrhythmia, and AF Clinics at UIC Medical Center, Advocate Heart Institute, and the Jesse Brown Veterans Affairs (JBVA) Medical Center were approached to participate in the registry over a 36-month period.…”

Section: Methodsmentioning

confidence: 99%

Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups

et al. 2018

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Key Points Question What is the association of family history with the pathogenesis of early-onset atrial fibrillation in patients of African, European, and Hispanic descent? Findings In this cohort study of 664 patients, probands with early-onset atrial fibrillation were significantly more likely to have a family history of arrhythmia in first-degree relatives than patients with non–early-onset atrial fibrillation. Compared with European American probands, African American and Hispanic/Latino probands with early-onset atrial fibrillation were more likely to have a first-degree relative with arrhythmia. Meaning These findings support genetic predisposition to early-onset atrial fibrillation across individuals of European, African, and Hispanic/Latino descent and have important implications for identifying family members at risk for atrial fibrillation and sequencing candidate genes.

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Section: Methodsmentioning

confidence: 99%

Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups

et al. 2018

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“…In 2018 the first genetic study of AF in Latinos was able to identify European-related AF SNPs in a Mexican American cohort. It showed the rs10033454 SNP, chromosome 4q25 (near PITX2), significantly associated with developing AF by as much as a 2.3-fold increase [ 28 ]. This SNP was linked to the phenotypical expression of proteins in charge of atrial action potential alterations causing ectopic trigger activity at the pulmonary veins.…”

Section: Discussionmentioning

confidence: 99%

Insight on the Genetics of Atrial Fibrillation in Puerto Rican Hispanics

González-Cordero

Duconge

Franqui-Rivera

et al. 2021

Stroke Research and Treatment

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Non-Hispanic whites present with higher atrial fibrillation (AF) prevalence than other racial minorities living in the mainland USA. In two hospital-based studies, Puerto Rican Hispanics had a lower prevalence of atrial fibrillation of 2.5% than non-Hispanic Whites with 5.7%. This data is particularly controversial because Hispanics possess a higher prevalence of traditional risk factors for developing AF yet have a lower AF prevalence. This phenomenon is known as the atrial fibrillation paradox. Despite recent advancements in understanding AF, its pathogenesis remains unclear. In this study, we compared a genetic dataset of Puerto Rican Hispanics to 111 SNP known to be associated with AF in a large European cohort and determine if they are associated with AF susceptibility in our cohort. To achieve this aim, we performed a secondary analysis of existing data using the following two studies: (1) The Pharmacogenetics of Warfarin in Puerto Ricans study and the (2) A Genomic Approach for Clopidogrel in Caribbean Hispanics, and assess for the presence of European SNPs associated with AF from the genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation. We used data from 555 cardiovascular Puerto Rican Hispanic patients, consisting of 486 control and 69 cases. We found that the following SNPs showed significant association with AF in PHR: rs2834618, rs6462079, rs7508, rs2040862, and rs10458660. Some of these SNPs are proteins involved in lysosomal activities responsible for breaking ceramides to sphingosines and collagen deposition around atrial cardiomyocytes. Furthermore, we performed a machine learning analysis and determined that Native American admixture and heart failure were strongly predictive of AF in PHR. For the first time, this study provides some genetic insight into AF’s mechanisms in a Puerto Rican Hispanic cohort.

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“…In the 65 and older population, AF prevalence was higher among males (10.5%) than females (8.4%) and was highest among Non-Hispanic Whites (10.2%), followed by American Indians/Alaska Natives (5.9%), Hispanics (5.0%), Blacks/African Americans (5.1%), and Asian Pacific Islanders (4.9%). The cause of these differences in prevalence is unknown but recent study suggests that there may be some genetic protection against AF in minority populations (29).…”

Section: Discussionmentioning

confidence: 99%

Renal Dysfunction Predicts Major Adverse Cardiovascular Events in Black and Latino Patients Who Have Atrial Fibrillation

Zeeshan¹,

Lehman²,

Naccarelli³

et al. 2021

Preprint

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Background: Atrial Fibrillation (AF) is present in over 6 million Americans. However, AF occurs less commonly in African Americans and Latinos compared to Caucasians. Major adverse cardiovascular events (MACE) is the leading cause of death in these populations. Hypothesis: We theorize that glomerular filtration rates (GFR) is an independent risk factor for MACE in African Americans and Latinos with non-valvular AF (NVAF). Methods: The association of reduced GFR with MACE in NVAF patients was investigated by retrospective chart review. 656 patients were included: 339 with GFR <60 and 317 with GFR ≥60. A Chi-square test, two-sample t-test, or Wilcoxon Rank Sum test was used to test for differences between the two groups in terms of demographic variables and other risk factors. The association between GFR groups and myocardial infarction (MI), stroke, and/or death, was tested using binomial logistic regression. To incorporate the element of time and adjust for covariates, a Cox proportional hazards model analysis was applied for each outcome variable. Results: As compared to GFR ≥60, a GFR <60 in NVAF was an independent risk factor for MI (HR 1.88 (1.17, 3.04); p=0.009); death (HR 1.63 (1.11, 2.41); p=0.014) and MI, stroke or death ((HR 1.37 (1.05, 1.78); p=0.018). GFR <60 was not an independent risk factor for stroke (HR 1.13 (0.77, 1.65); p=0.529) Conclusion: Renal dysfunction in patients with NVAF is an independent risk factor for MI, death in and composite of MI, stroke and death in African American and Latino populations.

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Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort

Cited by 13 publications

References 38 publications

Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups

Association Between Family History and Early-Onset Atrial Fibrillation Across Racial and Ethnic Groups

Insight on the Genetics of Atrial Fibrillation in Puerto Rican Hispanics

Renal Dysfunction Predicts Major Adverse Cardiovascular Events in Black and Latino Patients Who Have Atrial Fibrillation

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