Genetic Method for the Preferential Elimination of Females of
            <i>Anopheles albimanus</i>

Seawright, J. A.; Kaiser, P. E.; Da, Dame; Lofgren, C. S.

doi:10.1126/science.663614

Cited by 61 publications

(27 citation statements)

References 3 publications

(2 reference statements)

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“…5), it is able to achieve faster eradication than the proportional policy. Given that eggs can be stored for up to 2 years and that A. aegypti mosquitoes are easy to breed, 10 8 -10 9 could be stockpiled for a given project [Culex quinquefasciatus mosquitoes have been released at 3 ϫ 10 5 per day (29,30), and Anopheles albimanus mosquitoes have been released at 10 6 per day (30,31)], and given the female mosquito-to-human population ratio in endemic areas is Ϸ10 (20,26), it would appear that the RIDL strategy is capable of eradicating dengue fever for millions of people worldwide. The worldwide population in areas where dengue fever is endemic is Ϸ10 9 (32), suggesting that the number of adult female mosquitoes in these regions is Ϸ10 10 , and the total number of RIDL mosquitoes required for worldwide eradication is Ϸ10 11 .…”

Section: Discussionmentioning

confidence: 99%

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

Atkinson¹,

Zheng²,

Alphey

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

121

115

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Motivated by the failure of current methods to control dengue fever, we formulate a mathematical model to assess the impact on the spread of a mosquito-borne viral disease of a strategy that releases adult male insects homozygous for a dominant, repressible, lethal genetic trait. A dynamic model for the female adult mosquito population, which incorporates the competition for female mating between released mosquitoes and wild mosquitoes, density-dependent competition during the larval stage, and realization of the lethal trait either before or after the larval stage, is embedded into a susceptible-exposed-infectious-susceptible human-vector epidemic model for the spread of the disease. For the special case in which the number of released mosquitoes is maintained in a fixed proportion to the number of adult female mosquitoes at each point in time, we derive mathematical formulas for the disease eradication condition and the approximate number of released mosquitoes necessary for eradication. Numerical results using data for dengue fever suggest that the proportional policy outperforms a release policy in which the released mosquito population is held constant, and that eradication in Ϸ1 year is feasible for affected human populations on the order of 10 5 to 10 6 , although the logistical considerations are daunting. We also construct a policy that achieves an exponential decay in the female mosquito population; this policy releases approximately the same number of mosquitoes as the proportional policy but achieves eradication nearly twice as fast.dengue fever ͉ genetically modified mosquitoes ͉ mathematical epidemiology W orldwide morbidity and mortality from mosquito-borne viral diseases are substantial and on the rise (1). No licensed vaccine exists for the most important of these viruses, the dengue virus, which each year causes 50-100 million cases of dengue fever and 250,000-500,000 cases of the potentially fatal dengue hemorrhagic fever (2). The Aedes aegypti mosquito (also known as Stegomyia aegypti), which is the main vector for dengue fever and yellow fever, is endemic in the southeastern U.S., and the West Nile virus spread easily through the U.S. in recent years, suggesting the U.S. could be vulnerable in coming years to both natural and deliberate outbreaks of mosquito-borne viral diseases. Given the failure of current methods to control the spread of these diseases, considerable effort has gone into novel population-suppression strategies. The sterile insect technique (SIT), which releases sterile (irradiated) male insects that mate with wild females, resulting in no progeny, has been used successfully for Ͼ50 years for control and eradication of several pests and disease vectors (3, 4). However, irradiated mosquitoes have difficulty competing with wild males for wild females (5-7) and there are no large-scale SIT mosquito programs currently in operation. A proposed alternative approach that is also environmentally benign is the release of insects carrying a dominant lethal (RIDL) strategy. In this ap...

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Section: Discussionmentioning

confidence: 99%

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

Atkinson¹,

Zheng²,

Alphey

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

121

115

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“…MALE (Y)-linked translocations can be used in insect control in two ways, firstly to introduce sterility into populations (Wagoner eta!., 1969;Rabbani and Kitzmiller, 1975a;Baker et al, 1978) and secondly to enable genetic sexing techniques to be developed (Seawright et a!., 1978;Baker et a!., 1978;Whitten et a!., 1976;Curtis et a!., 1976;Curtis, 1978). Y-linked translocations with their associated semi-sterility are amongst the simplest types of rearrangement which can be used in genetic control as the translocation is passed to all the sons and none of the daughters, therefore they can be easily maintained in stock.…”

Section: Introductionmentioning

confidence: 99%

Complex Y-linked translocations in Delia antiqua produced by irradiation of a fertile Y-linked translocation

As¹,

K²

1981

Heredity

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SUMMARYIn the onion fly, Delia antiqua. a fertile, Y-linked translocation involving chromosomes Y and 2 was irradiated with fast neutrons to induce new complexes involving the Y-chromosome. This chromosome is male determining in the onion fly. Such complexes can be used for the development of genetic sexing systems and also for the introduction of sterility into field populations following release.Irradiation reduced egg fertility by 54 per cent and significantly reduced larval survival but it had no effect on the F1 sex ratio. By measuring the fertility of 807 F1 males following outcrossing, 112 semi-sterile progenies were isolated of which 11 were lost, 29 showed no inheritance of the semi-sterility, 59 were new autosomal translocations and 13 were new complex Y-linked translocations. This classification was accomplished by checking the fertilities of outcrossed F2 males and females. Following cytological observation it was revealed that one of these new complexes involved four chromosome pairs, the remainder involved three. There appeared to be no correlation between the fertility of the translocation and the complexity of the rearrangement. The utilization of these rearrangements in the development of the genetic sexing technique for the onion fly is discussed, together with an assessment of their use for fertility reduction in natural populations.

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“…GSMs based on the radiation-induced translocation of semi-dominant genes for insecticide resistance onto the Y chromosome were developed in An. gambiae and Anopheles albimanus (Curtis et al, 1976;Seawright et al, 1978). This system was used for the production of a million An.…”

Section: Developing An Effective Drive Mechanismmentioning

confidence: 99%

Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges

Riehle

Srinivasan

Moreira

et al. 2003

Journal of Experimental Biology

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SUMMARYMalaria kills millions of people every year, yet there has been little progress in controlling this disease. For transmission to occur, the malaria parasite has to complete a complex developmental cycle in the mosquito. The mosquito is therefore a potential weak link in malaria transmission, and generating mosquito populations that are refractory to the parasite is a potential means of controlling the disease. There has been considerable progress over the last decade towards developing the tools for creating a refractory mosquito. Accomplishments include germline transformation of several important mosquito vectors, the completed genomes of the mosquito Anopheles gambiae and the malaria parasite Plasmodium falciparum, and the identification of promoters and effector genes that confer resistance in the mosquito. These tools have provided researchers with the ability to engineer a refractory mosquito vector, but there are fundamental gaps in our knowledge of how to transfer this technology safely and effectively into field populations. This review considers strategies for interfering with Plasmodium development in the mosquito, together with issues related to the transfer of laboratory-acquired knowledge to the field, such as minimization of transgene fitness load to the mosquito, driving genes through populations, avoiding the selection of resistant strains, and how to produce and release populations of males only.

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Genetic Method for the Preferential Elimination of Females of Anopheles albimanus

Cited by 61 publications

References 3 publications

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

Complex Y-linked translocations in Delia antiqua produced by irradiation of a fertile Y-linked translocation

Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges

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