Genetic Mechanisms Involved in the Generation of HLA Alleles in Brazilians: Description and Comparison of HLA Alleles

Characterization of 15 novel HLA alleles by next generation sequencing in Brazilian individuals

“…The HLA genes are located within the human major histocompatibility complex (MHC) on the short arm of chromosome 6. The HLA genes are hyperpolymorphic many with thousands of allelic variants generated by different genetic mechanisms 1 . According to the latest version of the IPD‐IMGT/HLA Database (release 3.41.0, July 2020), there are currently over 27 500 HLA allele sequences have been identified in the world population 2 .…”

“…The HLA genes are hyperpolymorphic many with thousands of allelic variants generated by different genetic mechanisms. 1 According to the latest version of the IPD-IMGT/HLA Database (release 3.41.0, July 2020), there are currently over 27 500 HLA allele sequences have been identified in the world population. 2 We report here the sequences of 15 novel HLA alleles, detected in the HLA-A, -C, -DRB1, and -DQB1 genes.…”

Six novel HLA‐B, ‐DRB1, and ‐DQB1 alleles identified in Brazilian individuals

“…The HLA genes are characterized by enormous variation in the nucleotide sequences generated by different genetic mechanisms . Since the discovery of the HLA system over 50 years ago, continuous improvements in the identification of new variants have been achieved for better outcome of allogeneic tissue grafting, including solid organ and hematopoietic stem cell transplantation .…”

“…The HLA genes are characterized by enormous variation in the nucleotide sequences generated by different genetic mechanisms. 1,2 Since the discovery of the HLA system over 50 years ago, continuous improvements in the identification of new variants have been achieved for better outcome of allogeneic tissue grafting, including solid organ and hematopoietic stem cell transplantation. 3,4 In the latter context, understanding of the nature of the HLA variation between recipients and donors has helped reducing the risk of graftvs-host disease, thereby leading to lower transplant-related mortality.…”

Five novel HLA‐A, ‐B, and ‐C alleles identified in Brazilian individuals by next‐generation sequencing

“…2 New HLA alleles are generated by single nucleotide polymorphism (SNP), gene conversion, and insertion/deletion events. 3 In this report, we describe the full-length sequence of five new HLA class I alleles identified in healthy Brazilian individuals.…”