Genetic markers of the stress generation model: A systematic review

Bahji, Anees; Forth, Evan; Hargreaves, Tegan; Harkness, Kate L.

doi:10.1016/j.psychres.2021.114139

Cited by 13 publications

(13 citation statements)

References 66 publications

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“…Previous studies have shown that different types of stressful life events have different effects on mental health problems. For example, some studies have found that interpersonal stress and academic stress are associated with depressive symptoms, sleep quality, suicidal ideation, and PSU (81)(82)(83); another study showed that punishment significantly predicted depressive symptoms, but have no effects on poor sleep quality and suicidal ideation (84). Future research should examine the effects of specific types of stressful life events on different mental health problems.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Effects of Stressful Life Events on Problematic Smartphone Use and the Mediating Roles of Mental Health Problems in Chinese Undergraduate Students

Zhao

Ding

Yang

et al. 2021

Front. Public Health

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Background and Aims: This three-wave longitudinal study investigated the effects of stressful life events on problematic smartphone use and the mediating roles of mental health problems (i.e., depressive symptoms, poor sleep quality, and suicidal ideation) in Chinese undergraduate students.Methods: A total of 197 undergraduate students completed the three-wave surveys. Their severity of stressful life events, mental health problems, and problematic smartphone use were assessed.Results: Regression analyses revealed that stressful life events at T1 was significantly associated with problematic smartphone use at T3. Mediation analyses showed that mental health problems (i.e., depressive symptoms, poor sleep quality, and suicidal ideation) at T2 fully mediated the association between stressful life events at T1 and problematic smartphone use at T3 (B = 0.042, 0.034, and 0.022, respectively).Conclusions: The present study revealed that stressful life events and mental health problems (i.e., depressive symptoms, poor sleep quality, and suicidal ideation) are predictors of problematic smartphone use in Chinese college students.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Effects of Stressful Life Events on Problematic Smartphone Use and the Mediating Roles of Mental Health Problems in Chinese Undergraduate Students

Zhao

Ding

Yang

et al. 2021

Front. Public Health

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“…In the current study, we sought to build upon the existing literature on rGEs by examining whether genetic liability for depression, indexed by an established GWAS-derived DEP-PRS, was associated with stress exposure in a risk-enhanced sample of youth with and without a maternal history of MDD. Consistent with converging evidence from behavioral (Bemmels et al, 2008;Boardman et al, 2011;Kendler & Baker, 2007) and molecular (Bahji et al, 2021) genetic studies, we hypothesized that youth at increased genetic risk for depression would exhibit greater exposure to dependent, but not independent, life events. In doing so, we sought to determine whether relations between the DEP-PRS and stress exposure would be at least partially independent of mothers' histories of MDD, a known risk factor for both dependent and independent life stress (Adrian & Hammen, 1993;Feurer et al, 2016), which also contributes to offspring risk via environmental pathways (Goodman, 2020).…”

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confidence: 75%

“…Although behavioral genetics studies cannot delineate which genes contribute to rGEs, molecular genetic studies can provide insight regarding whether genetic liability for depression, more specifically, contributes to rGEs. Mirroring behavioral genetics research, there is emerging evidence that genetic variants associated with depression risk may be associated with increased risk for the generation of dependent life events (for review, see Bahji et al, 2021). Specifically, possessing one or two copies of the short allele of the serotonin transporter gene (5-HTTLPR) predicts increased generation of dependent stressful life events for adolescents with a history childhood maltreatment (Harkness et al, 2015), depression symptoms (Starr et al, 2012), or ADHD symptoms (Brinksma et al, 2018).…”

mentioning

confidence: 99%

Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene–environment correlations.

Feurer¹,

McGeary²,

Brick³

et al. 2022

Journal of Psychopathology and Clinical Science

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Familial risk for depression is associated with youth exposure to self-generated dependent stressful life events and independent events that are out of youth’s control. Familial risk includes both genetic and environmental influences, raising the question of whether genetic influences, specifically, are associated with youth exposure to both dependent and independent stressful life events. To address this question, this study examined the relation between a genome-wide association study (GWAS)-derived depression-based polygenic risk score (DEP-PRS) and youth experiences of dependent and independent stress. Participants were 180 youth (ages 8 to 14, 52.2% female) of European ancestry and their biological mothers recruited based on the presence versus absence of a history of major depressive disorder (MDD) in the mothers. Youth and mothers were interviewed every 6 months for 2 years regarding the occurrence of stressful life events, which were coded as independent or dependent (self-generated). Results indicated that youth’s DEP-PRS and maternal history of MDD were uniquely associated with increased exposure to both dependent and independent events. Similar results were observed when examining major versus minor events separately, with the additional finding of a DEP-PRS × mother MDD interaction for major dependent events such that levels of moderate to severe dependent life stressors were highest among youth with high DEP-PRSs who also had mothers with MDD. These results not only support the presence of depression-relevant gene–environment correlations (rGEs), but also highlight the possibility that rather than only capturing depression-specific genetic liability, GWAS-derived polygenic risk scores may also capture genetic variance contributing to stress exposure.

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“…A key question for future research is whether the observed relationship between genotype and level of perceived stress is due to a lower likelihood of perceiving experiences as stressful. A second potential explanation is the stress generation hypothesis, which suggests that people with higher levels of stress may be more likely to experience stress exposures (Bahji et al, 2021; Harkness & Washburn, 2016). Future studies should consider including measures of stress exposure as well as stress response.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic variants in the HPA axis and cytokine pathway contribute to variability in the physiological stress response and stress phenotypes (Hankin et al, 2015; Juster et al, 2010; Montag et al, 2020), and include 5HTTLPR, COMT, CRHBP, CRHR1, CXCL8/IL-8, FKBP5, HTR1B, HTR3B, IL-10, IL-1B, NR3C1, and OXTR (Bahji et al, 2021; Deussing, 2021; Di Iorio et al, 2017; Ersig et al, 2017; Huang & Starr, 2020; Marsland et al, 2007; Pagliaccio et al, 2014; Starr et al, 2019; Weeger et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease

Ersig

Young

Brown

et al. 2022

Biological Research For Nursing

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Background Persistently high chronic stress can lead to maladaptive psychological, behavioral, and physiological stress responses and poor mental and physical health, highlighting the importance of identifying individuals at increased risk. Chronic health condition diagnosis and genetics are 2 characteristics that can influence stress, stress response, and health outcomes. Purpose Food allergy (FA) and celiac disease (CD) require constant vigilance in daily life and can lead to increased stress. The purpose of this exploratory analysis was to examine the association of variants in selected stress-related genes with stress exposures, stress, clinical measures of physiological stress response, and mental health symptoms in adults with and without FA or CD. Methods We compared stress exposures, symptoms of PTSD, depression, anxiety, and stress, BMI, and waist-hip ratio between cases and controls. We analyzed the association of SNPs in genes with known or hypothesized associations with stress-related measures in 124 cases and 124 matched controls: CRHBP (rs7718461, rs10474485), CRHR1 (rs242940) and OXTR (rs2268490). For this exploratory study, p-values ≤ 0.10 were considered suggestive. Results For cases and controls, rs7718461 was associated with stress symptoms, rs2268490 with symptoms of stress and PTSD, and rs242940 with symptoms of stress, PTSD, anxiety, and depression. Further analyses found that stress-related outcomes in individuals with FA or CD may be influenced by SNP genotype. Conclusions Given these suggestive findings, larger prospective studies should examine similar relationships in individuals with other chronic health conditions, incorporating factors such as environmental exposures, individual experiences, and epigenetic modifications.

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Genetic markers of the stress generation model: A systematic review

Cited by 13 publications

References 66 publications

Longitudinal Effects of Stressful Life Events on Problematic Smartphone Use and the Mediating Roles of Mental Health Problems in Chinese Undergraduate Students

Longitudinal Effects of Stressful Life Events on Problematic Smartphone Use and the Mediating Roles of Mental Health Problems in Chinese Undergraduate Students

Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene–environment correlations.

Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease

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