GENETIC MARKERS OF GOATS (review)

Selionova, Marina

doi:10.15389/agrobiology.2021.6.1031eng

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…Long-term breeding to improve productivity while maintaining high adaptive qualities of goats affected changes in their genome, as evidenced by several studies of modern and ancient goat DNA [7,8]. The successful implementation of several international projects on goat genome research, the development of Goat 50K BeadChip and the use of genomewide associative analysis (GWAS) provided significant progress in the search for breeding prints and the identification of SNPs associated with different indicators of goat productivity [9][10][11]. The following groups of genes have been identified: controlling signs of lactic acid [12][13][14][15][16], down productivity and wool color [17,18], reproduction [19][20][21][22], as well as adaptations [23,24].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association and Pathway Analysis of Carcass and Meat Quality Traits in Karachai Young Goats

Selionova,

Aibazov,

Sermyagin

et al. 2023

Animals

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Goats with diverse economic phenotypic traits play an important role in animal husbandry. However, the genetic mechanisms underlying complex phenotypic traits are unclear in goats. Genomic studies of variations provided a lens to identify functional genes. The work aimed to search for candidate genes related to body measurements and body weight of Karachai goats and develop an experimental PCR-RV test system for genotyping significant SNPs. Comparison of GWAS results for ages 4 and 8 months revealed 58 common SNPs for significant genotypes. 11 common SNPs were identified for body weight, 4 SNPs—for group of traits withers height, rump height, body length, 2 SNPs—for withers height and rump height, 1 SNP—for body length and chest depth. Structural annotation of genomic regions covering a window of ±0.20 Mb showed the presence of 288 genes; 52 of them had the described functions in accordance with gene ontology. The main molecular functions of proteins encoded by these genes are the regulation of transcription, cell proliferation, angiogenesis, body growth, fatty acid and lipid metabolism, nervous system development, and spermatogenesis. SNPs common to body weight and localized within a window of ±200 kb from the structural genes CRADD, HMGA2, MSRB3, FUT8, MAX, and RAB15 were selected to create a test system. The study of meat productivity after slaughter and chemical analysis of muscle tissue in Karachai goats at the age of 8 months of different genotypes according to the identified SNPs revealed that rs268269710 is the most promising for further research and use in breeding. The GG genotype is associated with a larger live weight of animals, a larger carcass yield, the content of the boneless part in it, and the ratio of protein and adipose tissue in meat preferred for dietary nutrition. These results will contribute to the genetic improvement of Karachai goats.

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Section: Introductionmentioning

confidence: 99%

Genome-Wide Association and Pathway Analysis of Carcass and Meat Quality Traits in Karachai Young Goats

Selionova,

Aibazov,

Sermyagin

et al. 2023

Animals

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“…В России по численности коз первое место занимает Республика Тува, основное поголовье которых представлено советской шерстной породой и популяциями местных тувинских грубошерстных коз [18]. На основании информации, собранной в книгах учета администраций поселков, численность тувинских грубошёрстных коз в 2019 году определена на уровне 7200 голов [4].…”

Section: Introductionunclassified

Indicators of Downy Fiber Diameter of Tuva Male Goats Depending on Age

Irgit,

Khodusov,

Ponomareva

et al. 2023

SJLSA

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The strategy for the conservation of genetic diversity involves the cultivation of unique native breeds of animals. Tuva coarse-haired goats are relatively prolific, moderately early maturing, and, in addition to good meat productivity, have unique economically useful traits - very thin fluff. The purpose of the study was to study the productive indicators of Tuva coarse-haired goats and goats to identify age-related features of the morphometric parameters of the coat using an OFDA-2000 optical analyzer of the diameter of wool fibers. 18 months (n=20). The length of the down is 5.14±0.33 cm and 4.45±0.15 cm in goats and goats, respectively. The proportion of downy hair (diameter less than 30 µm) in the staple ranges from 85.0±1.23% to 87.37±1.34%. The amount of transitional hair is at the level of 3.85±0.82-4.62±0.65% (Cv 62.51-79.90%). With age, the animals tend to coarsen the fibers, this is evidenced by both the shift of the histogram peak from 16.20±0.40 µm in goats to 17.43±0.43 µm in goats, and changes in the structure of hair related to the awn ( goat wool contains 7.2 times more fibers with a diameter of more than 90 microns), We believe that when selecting Tuva goats to obtain high-quality down with the smallest fiber diameter, special attention should be paid, in addition to the length of the down and its diameter, to the presence of a transitional hair type (30.1-52.5 µm).

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“…Along with traditional methods of goat breeding, marker-assisted breeding based on the use of molecular genetic methods has become increasingly important in recent years [5,6]. Progress in genotyping technologies has made it possible to conduct genome-wide association studies (GWAS) to identify new single nucleotide polymorphisms (SNP) associated with indicators of body size that may affect the meat productivity of goats.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide analysis in the search for candidate genes associated with meat productivity traits in meat-and-dairy goats

Selionova

Aibazov

Sermyagin

et al. 2022

Teor. prakt. pererab. mâsa (Print)

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The development of the tourism cluster in the North Caucasus causes the expansion of product range with high consumer characteristics, in particular, a sustainable offer of dairy and meat products labeled as environmentally friendly. In the range of such products with high dietary properties, a special role may be played by goat meat obtained from Karachay goats, which are the most common meat-and-dairy goats in the region. The aim of the work was to search for candidate genes associated with live weight and meat productivity of Karachay goats. GWAS analysis using Goat 50K BeadChip high-density DNA microarray determined a genome-wide level of significance for six SNPs located on chromosomes 5, 6, 10 and 16 associated with the live weight of young animals (4 and 8 months old). Three of the six SNPs within the ± 200 kb region were localized to HMGA2, CRADD, and MAX genes. These genes were selected to study the meat productivity traits of young goats with different genotypes. It was found that in the locus linked with HMGA2 gene, young goats with GG genotype were characterized by the best indicators of meat productivity. Compared to AA genotype animals, they had superiority in pre-slaughter weight, slaughter carcass weight, slaughter yield, boneless meat weight and loin eye area by 8.9%, 13.6%, 4.3% (P<0.05), 10.5% (P<0.05) respectively. Young goat meat of this genotype was characterized by the high protein content of 22.56% and low fat content of 9.12%. For the CRADD gene, animals with GG genotype had a higher pre-slaughter weight, slaughter weight, slaughter carcass yield, boneless meat weight and loin eye area. Animals with AG genotype were characterized by the lowest indicators. According to the above characteristics, the difference between the compared genotypes was 15.8%, 25.7% (P<0.01), 8.4% (P <0.05), 18.3%, and 15.7% (P 0.01) respectively. There were no significant differences in the chemical composition of muscle tissue between animals of different genotypes. HMGA2 and CRADD genes are promising for further research of Karachay goats breeding to increase meat productivity and meat quality.

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GENETIC MARKERS OF GOATS (review)

Cited by 6 publications

References 67 publications

Genome-Wide Association and Pathway Analysis of Carcass and Meat Quality Traits in Karachai Young Goats

Genome-Wide Association and Pathway Analysis of Carcass and Meat Quality Traits in Karachai Young Goats

Indicators of Downy Fiber Diameter of Tuva Male Goats Depending on Age

Genome-wide analysis in the search for candidate genes associated with meat productivity traits in meat-and-dairy goats

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