Genetic Markers in Narcolepsy

Langdon, Nicola; Dam, MiekeVan; Welsh, K; Vaughan, R; Parkes, David G.

doi:10.1016/s0140-6736(84)92742-9

Cited by 195 publications

(68 citation statements)

References 13 publications

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“…The incidence of HLA DR 2 and DQw6 in patients with narcolepsy will vary among ethnic groups. [9][10][11][12][13][14][15] Even in China, extrapolation of results from one region to another can be problematic, as the HLA distribution in the North has more evidence of Caucasian admixture, while in the South, the HLA distribution is more similar to population in Southeast Asia. 16,17 One limitation to address is our choice not to routinely perform PSG testing before the MSLT.…”

Section: Discussionmentioning

confidence: 99%

Childhood Narcolepsy in North China

Han

Chen

Wei

et al. 2001

Sleep

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Section: Discussionmentioning

confidence: 99%

Childhood Narcolepsy in North China

Han

Chen

Wei

et al. 2001

Sleep

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“…Although narcolepsy is known to have a very high as- Downloaded from https://academic.oup.com/sleep/article-abstract/9/1/254/2742954 by guest on 06 June 2019 sociation with HLA-DR2 and DQwl (17)(18)(19), NIDDM is irrelevant to HLA. Therefore, genetic markers other than HLA should be investigated as the common genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Increased Frequency of Non-Insulin-Dependent Diabetes Mellitus Among Narcoleptic Patients

Honda

Doi

Ninomiya

et al. 1986

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142

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Summary: Forty-eight narcoleptic patients were randomly selected from a group of 197 narcoleptic outpatients, and a SO-g oral glucose tolerance test (OGTT) was performed. Blood glucose levels were determined by oximetry before and 30, 60, and 120 min after the glucose administration. Serum insulin concentrations (IRI) were determined by enzyme immunoassay, and an insulinogenic index (II) was calculated. (II = the ratio of IRI increment to blood glucose increment in 30 min following glucose load.) From the results of the OGTT, six patients with definite diabetes mellitus (DM) were identified (12.5%, 4 men and 2 women) according to World Heath Organization criteria (1980). The II of the DM patients was significantly low, with an average of 0.13 ± 0.03. From recent data in the literature on the prevalence of DM in the general Japanese adult population (1.75-5.5%), it was concluded that the frequency of DM among our randomly selected narcoleptic patients was significantly increased. The positive results for diabetes in our six narcoleptic patients could not be attributed to obesity, because there was no difference between the obesity indices of DM and nonDM narcoleptic patients, nor was there a difference between the frequency of DM in obese and nonobese patients. Key Words: Narcolepsy-Non-insulin-dependent diabetes mellitus--Oral glucose tolerance test-Obesity-Insulinogenic index.During the past 30 years, as we have treated and followed up several hundred narcoleptic patients at the Department of Neuropsychiatry, Tokyo University Hospital, we have had the impression that there were many diabetic patients among those with narcolepsy.With regard to the relationship between narcolepsy and diabetes mellitus (OM), only the reports by Roberts in 1964 0), 1965 (2), and 1967 (3) are available, to our knowledge. Roberts reported that 183 of 252 narcoleptic patients (72.6%) were diabetic. However, his diagnostic criteria for narcolepsy was ambiguous and not operational. More than half of his patients lacked cataplexy, and 50 had paroxysmal discharges on electroencephalogram. It may be that his patients had various disorders that would not meet today's criteria for the diagnosis of narcolepsy. Furthermore, his criteria of blood glucose levels for the di-

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“…1,2 Similar findings have been confirmed in narcoleptic patients of European and African decent, for whom the association is with DQB1*0602. 2,3 It has recently been reported that single-nucleotide polymorphism (SNP) rs1154155 located in the TCRA locus was associated with narcolepsy with cataplexy by means of a genomewide association study in European populations, and this association was replicated in Asian populations. 4 These findings suggest that immunological pathogenesis contributes to the development of narcolepsy with cataplexy.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB11501-DQB10602 haplotype

et al. 2009

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Essential hypersomnia (EHS) exhibits excessive daytime sleepiness without cataplexy and is associated with the HLA-DRB1*1501-DQB1*0602 haplotype, similar to narcolepsy with cataplexy. Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor a (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy. We investigated whether the SNP was associated with EHS in the Japanese population. We found a significant association with EHS patients possessing the HLA-DRB1*1501-DQB1*0602 haplotype, compared with HLA-matched healthy individuals (P allele ¼0.008; P positivity ¼5Â10 À4 ), whereas no significant association was observed for EHS patients without this haplotype. Thus, TCRA is a plausible candidate for susceptibility to EHS patients positive for the HLA-DRB1*1501-DQB1*0602 haplotype.

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Genetic Markers in Narcolepsy

Cited by 195 publications

References 13 publications

Childhood Narcolepsy in North China

Childhood Narcolepsy in North China

Increased Frequency of Non-Insulin-Dependent Diabetes Mellitus Among Narcoleptic Patients

Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB11501-DQB10602 haplotype

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Genetic Markers in Narcolepsy

Cited by 195 publications

References 13 publications

Childhood Narcolepsy in North China

Childhood Narcolepsy in North China

Increased Frequency of Non-Insulin-Dependent Diabetes Mellitus Among Narcoleptic Patients

Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype

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Product

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Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB11501-DQB10602 haplotype