Genetic Markers for Prediction of Normal Tissue Toxicity After Radiotherapy

Alsner, Jan; Andreassen, Christian Nicolaj; Overgaard, Jens

doi:10.1016/j.semradonc.2007.10.004

Cited by 101 publications

(66 citation statements)

References 88 publications

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“…the individual single-brand breaks (e.g., the precursors to type B damage) are assumed to be potentially repairable and, hence, sublethal. It thus follows that if the damage from the first sublethal event is repaired before the second event occurs, there will be no lethality (15). several various normal tissue damage end-points are known: cell-cell interactions, cell differentiation, extracellular matrix remodelling, cytokine and growth factor secretion, clonogenic cell survival, vascular damage, chromosomal aberrations and DNA repair (16).…”

Section: Fundamental Principles Of Radiation Therapymentioning

confidence: 99%

Radiotherapy and wound healing: Principles, management and prospects (Review)

Gieringer

Gosepath²,

Naim³

2011

Oncol Rep

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Abstract. radiation therapy is a major therapeutic modality in the management of cancer patients. Over 60% of these patients receive radiotherapy at some point during their course of treatment and over 90% will develop skin reactions after therapy. problematic wound healing in radiation-damaged tissue constitutes a major surgical difficulty and despite all efforts, irradiated skin remains a therapeutic challenge. this review provides an overview of the fundamental principles of radiation therapy with regards to the wound healing in normal and irradiated skin. Furthermore, it presents techniques that describe how to prevent and manage skin side effects as well as prospects that may improve cutaneous wound repair in general and in irradiated skin.

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Section: Fundamental Principles Of Radiation Therapymentioning

confidence: 99%

Radiotherapy and wound healing: Principles, management and prospects (Review)

Gieringer

Gosepath²,

Naim³

2011

Oncol Rep

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“…Research has shown the genetic factors influence cellular response associated with XRT [32]. Moreover, changes in gene expression in peripheral leukocytes have been seen in fatigue cancer patients receiving XRT [18,33].…”

Section: Introductionmentioning

confidence: 99%

Association between Mitochondrial Bioenergetics and Radiation- Related Fatigue: A Possible Mechanism and Novel Target

Hsiao¹

2015

Arch Can Res

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Background: Fatigue is one of the cancer symptoms most often reported by patients receiving radiation therapy (XRT). Understanding the mechanism behind the development of cancer-related fatigue will enable the design of novel interventions for radiation-induced fatigue. This research proposal is designed to determine the association between mitochondrial bioenergetics and fatigue in prostate cancer patients receiving XRT.

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“…Эти цитокины и факторы роста проду-цируются тромбоцитами и макрофагами, которые по-падают в раневое ложе в воспалительной фазе зажив-ления раны [42][43][44].…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

Clinical and morphological characteristics of skin and subcutaneous fat damage after surgical treatment and radiation therapy in patients with breast cancer (literature review)

Топузов¹,

Агишев²,

Bozhok³

et al. 2017

Tumors of female reproductive system

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ОПУХОЛИ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ TUMORS OF FEMALE REPRODUCTIVE SYSTEM Россия, 191015 Санкт-Петербург, ул. Кирочная, 41; 2 ГБУЗ ЛО «Ленинградский областной онкологический диспансер»; Россия, 191104 Санкт-Петербург, Литейный проспект, 37; 3 ГБУЗ «Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический)»; Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68А, лит. А; 4 ФГБУ «Научно-исследовательский институт онкологии им. Н. Н. Петрова» Минздрава России; Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68 Контакты: Тимур Тохирович Агишев tagishev@gmail.com В статье представлен обзор литературных источников по поздним лучевым повреждениям (ЛП) кожи и подкожно-жировой клетчатки после хирургического лечения и лучевой терапии (ЛТ) у больных раком молочной железы (РМЖ). В России у пациентов после ЛТ могут встречаться поздние ЛП с частотой, превышающей 10-15 %. При комбинированном лечении РМЖ (оперативном и лучевом) есть риск ЛП кожи и подкожно-жировой клетчатки, которое может приводить к дистрофическим изменениям в виде

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Genetic Markers for Prediction of Normal Tissue Toxicity After Radiotherapy

Cited by 101 publications

References 88 publications

Radiotherapy and wound healing: Principles, management and prospects (Review)

Radiotherapy and wound healing: Principles, management and prospects (Review)

Association between Mitochondrial Bioenergetics and Radiation- Related Fatigue: A Possible Mechanism and Novel Target

Clinical and morphological characteristics of skin and subcutaneous fat damage after surgical treatment and radiation therapy in patients with breast cancer (literature review)

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