Genetic mapping and manipulation: Chapter 2-Two-point mapping with genetic markers

Fay, David S.

doi:10.1895/wormbook.1.91.2

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Genome-wide Mutagenesis1

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“…In the past, two- and three-point mapping with genetic markers was used to identify the affected region, although this method is not commonly employed today (for a review, see the “Genetic mapping and manipulation” section in WormBook [20]). Single nucleotide polymorphism (SNP) mapping using the polymorphic Hawaiian isolate CB4856 is a more common approach [21].…”

Section: Genome-wide Mutagenesismentioning

confidence: 99%

Forward and reverse mutagenesis in C. elegans

Kutscher

Shaham

2014

WormBook

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Mutagenesis drives natural selection. In the lab, mutations allow gene function to be deciphered. C. elegans is highly amendable to functional genetics because of its short generation time, ease of use, and wealth of available gene-alteration techniques. Here we provide an overview of historical and contemporary methods for mutagenesis in C. elegans, and discuss principles and strategies for forward (genome-wide mutagenesis) and reverse (target-selected and gene-specific mutagenesis) genetic studies in this animal.

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Section: Genome-wide Mutagenesismentioning

confidence: 99%