1984
DOI: 10.1111/j.1365-3024.1984.tb00784.x
|View full text |Cite
|
Sign up to set email alerts
|

Genetic‐linked variation in susceptibility of mice to Schistosomiasis mansoni

Abstract: Genetic dependence of susceptibility to primary infection with Schistosoma mansoni was studied in inbred strains of mice. Eight weeks after the subcutaneous injection of 30 cercariae, C3H/HeJ (H-2k), DBA/1J (H-2q) and BALB/cJ (H-2d) had the highest number of adult worms per animal (8.0-9.8); DBA/2J (H-2d) and 129/J (H-2b) had an intermediate number (6.2-6.4); C57BL/6J (H-2b), BUB/BnJ (H-2q) and CBA/CaJ (H-2k) had the lowest number (3.4-4.0). Studies in congenic mice further suggested that genes within the majo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

1
8
0

Year Published

1986
1986
2002
2002

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 21 publications
(9 citation statements)
references
References 19 publications
1
8
0
Order By: Relevance
“…It was of interest to examine the susceptibility of 129/J mice bred al the Walter and Eliza Hall Institute (WEHI) to S. mansoni. Fanning and Kazura (1984) did not find any peculiarities in 129/J mice exposed to S. mansoni. In this paper we report that WEHI 129/J mice are resistant to S. mansoni (Puerto Rico) and that antibody specificities exist in sera from S. mansoni-expoxd 129/J mice that are nol apparent in sera from S. mansoni-infecled BALB/c mice.…”
Section: Introductionmentioning
confidence: 67%
See 1 more Smart Citation
“…It was of interest to examine the susceptibility of 129/J mice bred al the Walter and Eliza Hall Institute (WEHI) to S. mansoni. Fanning and Kazura (1984) did not find any peculiarities in 129/J mice exposed to S. mansoni. In this paper we report that WEHI 129/J mice are resistant to S. mansoni (Puerto Rico) and that antibody specificities exist in sera from S. mansoni-expoxd 129/J mice that are nol apparent in sera from S. mansoni-infecled BALB/c mice.…”
Section: Introductionmentioning
confidence: 67%
“…A protein that did not appear to be recognized differentially by sera from the two types of mice was a dominant antigen of Mr 27.000. The relationship of this molecule to the Mr 28,000 .n f I ; ; PP "-" "'"^'^ ^^P°"'='^ ">' F^""i"g and Kazura (1984) usin. a different ou ce of 129/J m,ce.…”
Section: Discussionmentioning
confidence: 96%
“…These include the high susceptibility of 129/J mice to infection with Sendai and CMV viruses and the induction of systemic lupus erythematosus as well as differences in their susceptibility to experimental autoimmune encephalomyelitis (25,26,29,30). 129/J mice are also more susceptible to infection with Schistosoma mansoni than are B6, and when infected with the intraerythrocytic Babesia-like organism, WA-1, 129/J mice exhibit higher levels of peak parasitemia and a 5-fold higher mortality rate (43,44). The role for NK cells in general, or DAP12-coupled receptors specifically, in these processes is poorly defined.…”
Section: Discussionmentioning
confidence: 99%
“…In mice exposed to Schistosoma mansoni, the host response to the parasite appears to be subject to genetic control. This is seen as the variation between inbred mouse strains in the establishment of adult worm burdens (Bickle et al 1980;Colley & Freeman 1980;Dean 1983;Fanning & Kazura 1984), the resistance to challenge infections of mice previously vaccinated with irradiated cercariae (Sher et al 1984) and the late modulation of hepatosplenomegaly, portal venous pressure and granuloma size in chronically infected mice (Fanning & Kazura 1981). Attempts to correlate such variation with the genetic constitution of the mouse strains have yielded equivocal results but suggest that genes both within and outside the major histocompatibility complex are involved (Sher et al 1984, Fanning & Kazura 1985.…”
Section: Introductionmentioning
confidence: 99%