Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

Moffatt, Miriam F.; Hill, Marguerite; Cornélis, François; Schou, C.; Faux, J. A.; Young, R. P.; James, Alan; Ryan, Gerard; Souëf, P. Le; Musk, Arthur W.

doi:10.1016/s0140-6736(94)93057-0

Cited by 214 publications

(98 citation statements)

References 14 publications

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“…Dorion and Leung 21 have proposed that restricted use of the V␤ 2 T cell receptor (TCR) may account, for the severity of the immune response to peanut allergens. Moffatt et al 22 have also described an association between T-cell receptor ␣/␦ complex and specific IgE responses to the dust mite allergen but no linkage was found with the ␤ chain.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism in the STAT6 gene encodes risk for nut allergy

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Polymorphism in the STAT6 gene encodes risk for nut allergy

et al. 2002

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“…Prick Skin Tests to HDM (Dermatophagoides pteronyssinus) and mixed grass pollen (less the response of negative controls), specific IgE titres to HDM and Timothy Grass (Phleum pratense) and the total serum IgE were measured as described previously. 48,49 A 'Prick Skin Test Index (PSTI)' was calculated as the sum of the prick skin test results to HDM and grass mix (95% of individuals who were atopic reacted either to HDM, or to grass pollen or both). The RASTI was defined as the sum of the RAST scores for the serum IgE concentration specific to the same two allergens.…”

Section: Phenotyping Of Atopy Panels a And Bmentioning

confidence: 99%

PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders

et al. 2005

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Variation in genes encoding costimulatory molecules expressed on lymphocytes has been expected to contribute to the genetic component of inflammatory disease, but only the gene encoding the inhibitory protein, CTLA-4, seems consistently to confer disease susceptibility. Studies in murine models implicate the inhibitory product of the pd1 gene, programmed death-1, in the maintenance of peripheral tolerance to self-antigens. We identify 22 single-nucleotide polymorphisms (SNPs) in the equivalent human gene, PDCD1, a number of which show significant associations with the specific immunoglobulin E response to grass allergens in atopic individuals. Stepwise analyses indicate that four of the disease-associated SNPs have independent effects. The two most common haplotypes show positive and negative associations but rarer haplotypes are also likely to be of influence. In a case-control study, multiple regression analysis of genotypic data implies that PDCD1 also confers susceptibility to rheumatoid arthritis. Along with work linking PDCD1 with susceptibility to another autoimmune condition, systemic lupus erythematosus, our data identify PDCD1 as a second immunomodulatory gene with pleiotropic effects in human disease. Genes encoding negative regulators may generally confer a significant fraction of the genetic risk associated with inherited inflammatory disorders.

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“…The TCRB segments TCRBV6S1 and TCRBV6S7 were investigated. However, we concentrated on the TCRA gene because of the recent demonstration of linkage with IgE-specific responses underlying atopy, another disease involving T cells (9), and because we had, from preliminary family studies, some suggestion of linkage to TCRA in RA (10).…”

mentioning

confidence: 99%

Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor

Cornélis

Hardwick

Flipo

et al. 1997

Arthritis & Rheumatism

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Objective. To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility. Methods.We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 control subjects. Productive changes of segments TCRAV6S1, TCRAV7S1, TCRAVSSl, TCRAVlOS2, and TCRBV6S1, TCRBV6S7 were investigated by singlestrand conformation polymorphisms. The TCRAVSSl association was confirmed by restriction fragment length polymorphism.Results. In the systematic study (77 patients and 119 controls), an increase in 1 TCRAVSSl genotype was found in the RA patients (P = 0.0004). This finding was replicated in 2 further populations, one from France Conclusion. These findings show evidence that TCRA is an RA susceptibility locus.

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Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

Cited by 214 publications

References 14 publications

Polymorphism in the STAT6 gene encodes risk for nut allergy

Polymorphism in the STAT6 gene encodes risk for nut allergy

PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders

Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor

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