2005
DOI: 10.1016/j.neuropharm.2004.11.015
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Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

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Cited by 199 publications
(161 citation statements)
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“…Still, even in hamsters there are actions of serotonin on the circadian system mediated at the level of the SCN (Weber et al 1998), and serotonin agonists reset the mouse SCN in vitro (Prosser 2003). The mechanism by which serotonin agonists reset the circadian clock in vitro is still unclear, and may involve the 5HT 1A , 5HT 5A and 5HT 7 receptor subtypes (Sprouse et al 2005;Guscott et al 2005). The agonist 8-OH-DPAT can act on both the 5HT 1A and 5HT 7 subtype.…”
Section: Discussionmentioning
confidence: 99%
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“…Still, even in hamsters there are actions of serotonin on the circadian system mediated at the level of the SCN (Weber et al 1998), and serotonin agonists reset the mouse SCN in vitro (Prosser 2003). The mechanism by which serotonin agonists reset the circadian clock in vitro is still unclear, and may involve the 5HT 1A , 5HT 5A and 5HT 7 receptor subtypes (Sprouse et al 2005;Guscott et al 2005). The agonist 8-OH-DPAT can act on both the 5HT 1A and 5HT 7 subtype.…”
Section: Discussionmentioning
confidence: 99%
“…With the exception of NPY, NMDA and DPAT which have shown to reset the mammalian circadian clock of the mouse in a manner similar to hamsters and/or rats (Guscott et al 2005;Soscia and Harrington 2004), the other transmitters have not been shown to be effective as resetting agents within the mouse SCN. Testing these agents in mice is particularly important as much circadian work now takes advantage of developed molecular tools only available in the mouse model.…”
Section: Discussionmentioning
confidence: 99%
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“…The 5-HT 7 receptor subtype, the most recently cloned of the serotonin receptor subtypes, modulates many physiological and behavioral functions, including circadian rhythms (Ehlen et al, 2001;Duncan et al, 2004;, rapid eye movement (REM) sleep (Hagan et al, 2000;Thomas et al, 2003;Monti and Jantos, 2006), body temperature (Hedlund et al, 2003), learning and memory (Roberts et al, 2004), and behavior (Guscott et al, 2005;Hedlund et al, 2005). For example, administration of the 5-HT 7 receptor-selective antagonists, SB-269970-A or DR-4004, to hamsters blocks phase advances of circadian locomotor activity rhythms induced by the serotonergic agonists, 8-OH-DPAT or 5-carboxamidotryptamine, demonstrating that pharmacological activation of 5-HT 7 receptors stimulates circadian phase resetting (Ehlen et al, 2001;Duncan et al, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Also, administration of 5-HT 7 receptor-selective antagonists to guinea pigs or rats selectively decreases REM sleep, suggesting that endogenous serotonin acting at 5-HT 7 receptors exerts a tonic inhibition on REM sleep (Hagan et al, 2000;Thomas et al, 2003;Monti and Jantos, 2006). Furthermore, studies in mice have shown that deletion of the 5-HT 7 receptor gene impairs memory and learning (Roberts et al, 2004), reduces immobility in the Porsolt swim test, similar to antidepressants (Guscott et al, 2005;Hedlund et al, 2005), and inhibits hypothermia induced by 8-OH-DPAT (Hedlund et al, 2003).…”
Section: Introductionmentioning
confidence: 99%