Genetic Investigation of Autism-Related Social Communication Deficits

Campbell, Jerry L.

doi:10.1176/appi.ajp.2014.14121503

Cited by 3 publications

(1 citation statement)

References 20 publications

(13 reference statements)

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“…The approaches to understanding neural mechanisms in behavior outlined here may also influence our understanding of affective processes that support attachment behaviors across species. Modularity in affective-related constructs like valence processing, reward, fear or stress response, and motivation, as well as a distributed circuitry across brain regions for encoding these affective states, is reflected in behavioral domains as well as endophenotypes within clinical syndromes (Anderson & Adolphs, 2014 ; Braff, 2015 ; Campbell, 2015 ; Jeste & Geschwind, 2014 ). Using the framework outlined, which strives to incorporate manipulations to behavioral systems at various developmental timepoints with context-specific perturbations to defined components of the circuitry, we can begin to address whether affective substrates become associated with behavioral states like pair bonding only with experience or whether they are fundamental to the developmental specification of attachment circuitry.…”

Section: Discussionmentioning

confidence: 99%

Rethinking the Architecture of Attachment: New Insights into the Role for Oxytocin Signaling

Berendzen

Manoli

2022

Affec Sci

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Social attachments, the enduring bonds between individuals and groups, are essential to health and well-being. The appropriate formation and maintenance of social relationships depend upon a number of affective processes, including stress regulation, motivation, reward, as well as reciprocal interactions necessary for evaluating the affective state of others. A genetic, molecular, and neural circuit level understanding of social attachments therefore provides a powerful substrate for probing the affective processes associated with social behaviors. Socially monogamous species form long-term pair bonds, allowing us to investigate the mechanisms underlying attachment. Now, molecular genetic tools permit manipulations in monogamous species. Studies using these tools reveal new insights into the genetic and neuroendocrine factors that design and control the neural architecture underlying attachment behavior. We focus this discussion on the prairie vole and oxytocinergic signaling in this and related species as a model of attachment behavior that has been studied in the context of genetic and pharmacological manipulations. We consider developmental processes that impact the demonstration of bonding behavior across genetic backgrounds, the modularity of mechanisms underlying bonding behaviors, and the distributed circuitry supporting these behaviors. Incorporating such theoretical considerations when interpreting reverse genetic studies in the context of the rich ethological and pharmacological data collected in monogamous species provides an important framework for studies of attachment behavior in both animal models and studies of human relationships.

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Section: Discussionmentioning

confidence: 99%

Rethinking the Architecture of Attachment: New Insights into the Role for Oxytocin Signaling

Berendzen

Manoli

2022

Affec Sci

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Mark's Story

Kent

Tissot

2022

Research Anthology on Physical and Intellectual Disabilities in an Inclusive Society

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The personal story of Mark Kent is not an easy one to read or to ignore. This chapter shares the difficult life story of Mark's journey from an individual who was sexually and emotionally abused as a child to one where he is currently in a healthy and happy marriage with four children. Mark attributes this success to his Asperger's Syndrome and the support of his family, but he also realizes he is an exceptional case study. He advocates for much better awareness, sexual education, and overall acceptance on the part of society to ensure others can overcome the same challenges he has faced.

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