Genetic investigation in mesangial IgA nephropathy

Abstract

HLA—A, B. C. DR, MB, Bf, Gm, Am, Pi and Km genes (and 12 erythrocyte genetic systems) have been analyzed and correlated with clinical or biological features in 88 mesangial IgA glomerulonephritis. These data pointed out 2 gene frequency modifications: a significant MB1 specificity decrease in the total patient group and a significant Km I increase in the chronic renal failure mesangial IgA nephropathy subgroup.

B cell alloantigens in Sicilian patients with Crohn's disease

“…the decrease of MT1 and the increase of MT3 found in our patients may be in agreement with the reduction of DR2 and the increase of DR7 reported in previous studies (see references in Kirsner & Shorter 1982). There is indeed a strong association between MT and MB antigens, and DR antigens (Park et al 1980, Duquesnoy & Marrari 1980 Frequencies of HLA-DR, M T and M B antigens in 28 patients with Crohn's disease and 132 controls') Petit et al 1982, Miyanaga et al 1981, Volkman et al 1982. In our patients the gene for susceptibility to Crohn's disease appears to be associated with the MT3 gene, whereas the gene for resistance appears to be associated with the MT1 (MB1) gene.…”

Idiopathic IgA Mesangial Nephropathy

“…As for other genetic systems, the allotype study of the kappa light chain (Km) demonstrated a significant in crease of Km I only in the subgroup of patients with chronic renal failure [57] and the study of gamma heavy chain (Gm) showed a significant increase of one allotype, only in the subgroup presenting with macroscopic he maturia [58]. However, the majority of these studies of immunogenetics have been performed with small num bers of patients, and their results must be confirmed in larger populations to become really convincing.…”

Mesangial Glomerulonephropathy with Decreased Circulating C4 and Predominant Mesangial C4 Deposition in Association with One Null Gene at the C4B Locus

“…Furthermore, when com pared with 51 cases of IgA nephropathy diagnosed at our institution over a 5-year period, these IF findings were unique (table II). Finally, HLA phenotyping of the pa tient and father revealed the absence of BW35, BW12, and DR4 -phenotypes previously associated with IgA nephropathy [19][20]. Nor are the features of this present 51 (100) 35 (69) 22 (43) 10 (20) 47 (92) 21 (41) 1 Three to six glomeruli were studied by IF; all staining was limited to stalk or mesangial areas.…”