Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases
Manuela Alvarado Obando,
Diego Rey-Varela,
Felipe Cava
et al.
Abstract:Peptidoglycan (PG) is the main component of the bacterial cell wall; it maintains cell shape while protecting the cell from internal osmotic pressure and external environmental challenges. PG synthesis is essential for bacterial growth and survival, and a series of PG modifications are required to allow expansion of the sacculus. Endopeptidases (EPs), for example, cleave the crosslinks between adjacent PG strands to allow the incorporation of newly synthesized PG. EPs are collectively essential for bacterial g… Show more
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