Genetic Instability in Peripheral Lymphocytes as Biological Marker for Non-Small Cell Lung Cancer Patients in the South Indian State of Andhra Pradesh

Abstract

We here report, for the first time, that the NSCLC patients selected form the Andhra Pradesh population had increased DNA damage and higher mean micronucleus frequencies in peripheral lymphocytes, indicating a strong background level of genetic instability.

Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

“…A majority of the patients included in our study were bidi smokers (made of crude particles of dried tobacco leaves wrapped in a tendu or temburni leaf and rich in tar and nicotines); and bidi smoking is known to generate stronger carcinogen load than cigarette [ 52 ]. Our data clearly indicate that individuals who were smokers and had CYP1A1m1 T/C, C/C or CYP1A1m2 A/G, G/G genotypes and GSTT1 null genes were at higher risk of disease susceptibility to lung cancer.…”

Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana

“…Lung cancer contributes to 17.5 % of total cancer deaths [1], and the majority of these are diagnosed to be non-small cell lung cancer (NSCLC) [2]. Chronic inflammation and immunosuppression mediated by cytokines contribute to the pathogenesis of lung cancer [3][4][5].…”

Association of eNOS and ACE gene polymorphisms and plasma nitric oxide with risk of non‐small cell lung cancer in South India

“…Among the various types of cancers, lung cancer is the second most common in both men and women, thus contributing to 27% of all cancer deaths (http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/non-small-cell-lung-cancer-key-statistics). Among the two types of lung cancer namely, non‐small cell lung cancer (NSCLC) and small cell lung carcinoma (SCLC), 85% of the patients are diagnosed with NSCLC . Though treatment strategies have improved considerably in the last decade, detection of NSCLC in the initial stages increases the chances of survival.…”