Genetic Instability in Gastric Cancer

Hudler, Petra; Vogelsang, Matjaž; Komel, Radovan

doi:10.5772/23669

Cited by 3 publications

(3 citation statements)

References 159 publications

(170 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased risk of cancer development in individuals infected with this bacteria has been associated with polymorphisms in genes implicated in gastric acid secretion, immune response, adhesion to epithelial cells, and other biological functions [ 4 ]. For example, it has been reported that a combination of polymorphisms within proinflammatory genes IL-1 β , IL-1RA, TNF α , and IL-10 conferred greater risk for gastric cancer development in combination with Helicobacter pylori infection [ 77 , 78 ]. Although the exact mechanisms of Helicobacter-pylori -induced carcinogenesis are not yet elucidated, it is believed that the combination of microenvironment, virulent microorganism, persistent inflammation response, and a genetically susceptible host drives the process of gastric cell transformation [ 79 ].…”

Section: Chromosomal Instability (Cin)mentioning

confidence: 99%

“…Patients with MSI phenotype exhibit a high frequency of replication errors resulting in insertions/deletions of nucleotides within microsatellite repeats in tumour tissues [ 5 ]. These errors are detected and repaired by a complex of mismatch repair (MMR) proteins [ 78 ]. Inactivation or deficiency of one or more MMR genes, particularly MLH1 or MSH2 , induces development of MSI phenotype, which often leads to additional genetic changes, namely inactivation of tumour suppressor genes and LOH [ 80 , 81 ].…”

Section: Microsatellite Instability (Msi)mentioning

confidence: 99%

See 1 more Smart Citation

Genetic Aspects of Gastric Cancer Instability

Hudler

2012

The Scientific World Journal

Self Cite

View full text Add to dashboard Cite

Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous disease, and although much has been learned about the different genetic changes that eventually lead to its development, the detailed mechanisms still remain unclear. Malignant transformation of gastric cells is the consequence of a multistep process involving different genetic and epigenetic changes in numerous genes in combination with host genetic background and environmental factors. The majority of gastric adenocarcinomas are characterized by genetic instability, either microsatellite instability (MSI) or chromosomal instability (CIN). It is believed that chromosome destabilizations occur early in tumour progression. This review summarizes the most common genetic alterations leading to instability in sporadic gastric cancers and its consequences.

show abstract

Section: Chromosomal Instability (Cin)mentioning

confidence: 99%

Section: Microsatellite Instability (Msi)mentioning

confidence: 99%

Genetic Aspects of Gastric Cancer Instability

Hudler

2012

The Scientific World Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…All collectively exponentiate this gene among the most frequently mutated genes in cancers [14]. Still studies are needed to settle the issue regarding the prevalence of TP53 mutations and its relationship to clinicopathological features of GC [13, 15]. Frequent p53 mutation has been shown in many human cancers; thus, this gene has been associated with carcinogenesis in humans.…”

Section: Introductionmentioning

confidence: 99%

Association of p53 Gene Mutation With Helicobacter pylori Infection in Gastric Cancer Patients and Its Correlation With Clinicopathological and Environmental Factors

et al. 2019

View full text Add to dashboard Cite

Background Gastric cancer is also a leading cancer in Bangladesh like that of the global incidences. It is speculated that environmental, bacterial infection and molecular factors might have been carrying the key role of rising trend of the disease. This study was aimed to investigate the association of mutated p53 gene with of Helicobacter pylori ( H. pylori ) infection, clinicopathological and some environmental factors of the gastric cancer patients. Methods This cross-sectional study was carried out from January 2015 to December 2016 in a specialized cancer hospital of Bangladesh. Patients were selected randomly who were admitted for surgical intervention after diagnosis as adenocarcinoma of the stomach and physically fit for surgery. After admission proper evaluation of the patients was done. Tissue sample from the gastrectomy specimen along with the blood sample was sent to the related laboratories. After DNA extraction for p53 , exons 5 and 6, they were adjusted for proper primer designing. Appropriate sequencing analysis of the result was done. Status of p53 was investigated to see their association with the result of the H. pylori , age and sex, tumor status, smoking and extra salt intake of the patients. Result of the study was calculated and analyzed by Chi-square and binomial logistic regression to find the association amongst them. Results Among the 71 patients, mean age was 52.96 years old, male: female ratio were 48:23, age group above 41 years were 53 (74.6%), proliferative and ulceroproliferative group of the tumor dominated (87.3%). There were 52 cases with (73.2%) p53 mutation. Among the 51 H. pylori positive cases, 41 (80%) had p53 mutation (P = 0.033). Tumor size and lymph node status were found to be associated with the gene mutation (P = 0.05). Age also had strong correlation with the mutation (P = 0.015). Gene mutation was found mostly among the younger (≤ 40 years) group of patients (94.4%). Patient with extra salt intake was also found related with the mutation (P = 0.03). Conclusions Environmental and genetic factors seem to be risk factors for gastric cancer in Bangladesh. Nationwide anti H. pylori drive and further molecular research could elicit the other risk factors which might help to reduce the gastric cancer incidences in the country after taking appropriate measures.

show abstract

Gastric Cancer: Molecular Pathology State

Altieri¹,

Arcari²,

Rippa³

2013

Current Topics in Gastritis - 2012

View full text Add to dashboard Cite

Despite the progressive decrease observed in the past fifty years, gastric cancer GC is the fourth of the world rankings incidence of various types of cancer and is the second as a cause of cancer-related death. There is distinct geographical variation in gastric cancer incidence with the highest rates reported from Japan, Korea and Eastern Asia. Other high incidence areas are Eastern Europe and parts of Latin America, while Western Europe, Africa, Australia and the US generally have low incidence rates. In the last decade there has been a downward trend in the incidence and mortality from this cancer. The reasons are to be found in the improvement of food both as regards its preservation procedures and the variability in the diet and for the decrease of infection by Helicobacter pylori H. pylori . H. pylori infection is strongly associated with risk for stomach cancer. Likely, this association is supported by the strong link between this bacterium infections and precancerous lesions, including chronic atrophic gastritis and dysplasia. The development of gastric cancer is characterized by multistage process in which several alterations of genetic and epigenetic nature accumulate. These alterations are mainly related to abnormalities of growth factors and receptors, DNA mismatch repair genes, angiogenic factors, transcription factors, adaptor proteins, cell cycle regulators, and many other macromolecular cell components. All these abnormalities identify from one side the molecular and biological aspect of gastric cancer cells and from the other might suggest possible strategies for therapeutic intervention.The most important epigenetic alterations are confined within the chromatin structure like chromatin remodeling, DNA methylation and histone modification. These molecular alterations are generally common in gastric cancer, independently from its classification gastric or intestinal . Also genetic polymorphism represents a possible endogenous cause of cancer risk. However, it must be considered that genetic polymorphisms might influence the efficacy of gastric cancer therapy and the toxicity of anticancer drugs. Although the worldwide decline in incidence and recent diagnostic and therapeutic advances provided excellent survival for

show abstract

Genetic Instability in Gastric Cancer

Cited by 3 publications

References 159 publications

Genetic Aspects of Gastric Cancer Instability

Genetic Aspects of Gastric Cancer Instability

Association of p53 Gene Mutation With Helicobacter pylori Infection in Gastric Cancer Patients and Its Correlation With Clinicopathological and Environmental Factors

Gastric Cancer: Molecular Pathology State

Contact Info

Product

Resources

About