Genetic influences onDSM-III-R drug abuse and dependence: A study of 3,372 twin pairs

Tsuang, Ming T.; Lyons, Michael J.; Eisen, Seth A.; Goldberg, Jack; True, William R.; Lin, Nong; Meyer, Joanne M.; Toomey, Rosemary; Faraone, Stephen V.; Eaves, Lindon J.

doi:10.1002/(sici)1096-8628(19960920)67:5<473::aid-ajmg6>3.0.co;2-l

Cited by 433 publications

(248 citation statements)

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“…Adoption and twin studies have provided evidence that heritable factors play important roles in the etiology of alcohol dependence (AD) 1,2 and drug (cocaine and opioids) dependence (DD), 3,4 although the influence of environmental factors (for example, psychological and socio-cultural ones) on AD and DD is also substantial. A rational etiological model for AD and DD is that they result from the interaction of multiple genes and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

et al. 2007

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Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 with opioid dependence (OD), and 443 controls). Nominally significant associations (P < 0.05) of five SNPs with SD were observed; only the association of the non-synonymous variant G80T with OD remained significant after correction for multiple testing using SNPSpD. Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (v 2 = 14.82, degrees of freedom (d.f.) = 1, P < 0.001), CD (v 2 = 9.19, d.f. = 1, P = 0.002) and OD (v 2 = 20.68, d.f. = 1, P < 0.001). Logistic regression analyses, with sex and age being considered, demonstrated that this haplotype had a risk effect on AD (P = 0.03, b = 1.86, odds ratio (OR) = 6.43) and especially on OD (P < 0.001, b = 3.92, OR = 50.57). Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). Although no significant differences in allele, genotype or haplotype frequency distributions were seen between cases and controls, a specific OPRK1 haplotype, GGCTTCT, was significantly associated with AD (v 2 = 8.12, d.f. = 1, P = 0.004). Logistic regression analyses also revealed its risk effect on AD (P = 0.009, b = 1.06, OR = 2.90). Population stratification artifact was not observed in the sample. Taken together, our findings supported a positive association between OPRD1 variants and SD, and a positive haplotypic association between OPRK1 and AD in EAs.

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Section: Introductionmentioning

confidence: 99%

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

et al. 2007

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“…In adults, genetic factors contribute to 40-60% of the total variance in risk for alcohol dependence (Dick et al, 2006;Heath et al, 1997;Kendler et al, 1994;Prescott et al, 1995;Tsuang et al, 2001), while for illegal drug dependence, estimates of heritability range from 35-75% (Kendler et al, 2003a;Lynskey et al, 2002;Tsuang et al, 1996;Tsuang et al, 2001;van den Bree et al, 1998). Results from multivariate twin analyses suggest that (i) the liability for dependence on various illicit drug classes is governed, in part, by common genetic factors (Kendler et al, 2003a;Tsuang et al, 1998), and (ii) a significant proportion of the genetic influences on alcohol and illicit drug dependence may be overlapping (Bierut et al, 1998;Kendler et al, 2003b;McGue et al, 2000;Tsuang et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

Agrawal

Hinrichs

Dunn

et al. 2008

Drug and Alcohol Dependence

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Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol

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“…Adolescent problem behavior; disinhibitory psychopathology; externalizing; twin studies Behavioral genetic research has established the importance of both heritable and non-heritable influences on the development of adult substance use disorders (SUDs) including: nicotine dependence (Heath and Madden, 1995;Kendler et al, 1999), alcohol dependence Kendler et al, 1992;McGue, 1999;, and illicit substance abuse and dependence (Ball and Collier, 2002;Kendler and Prescott, 1998;Lynskey et al, 2002;McGue et al, 2000;Tsuang et al, 1996). Current behavioral genetic research aims to build on these findings by identifying the specific genetic and environmental factors that affect SUD risk and by characterizing their joint mechanisms of actions (Rutter et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

The Association of Early Adolescent Problem Behavior and Adult Psychopathology: A Multivariate Behavioral Genetic Perspective

2006

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Research has documented a strong association between early adolescent problem behavior and adult disinhibitory psychopathology, leading some to suggest that the latter can be reduced by preventing or delaying the former. But the prevention implications of this association necessarily depend upon the causal mechanisms that produce it. The current study was designed to test implications of a model that posits that early problem behavior and disinhibitory psychopathology are associated because they are both manifestations of a common inherited liability. At their age-17 assessment, 1080 twins from the older cohort of the Minnesota Twin Family Study reported whether and the age at which they first: drank alcohol, used tobacco, used illicit drugs, had sexual intercourse, and had police contact. An Early Problem Behavior index was computed by summing the number of these experiences each participant reported having before age 15. Outcome measures of disinhibitory psychopathology were assessed by clinical interview at the age-20 follow-up and included number of symptoms of nicotine dependence, alcohol abuse and dependence, drug abuse and dependence, and adult antisocial behavior. Biometric analysis of the multivariate twin data showed that: (1) early adolescent problem behavior is weakly heritable (approximately 20%), (2) the common factor underlying disinhibitory psychopathology is strongly heritable (approximately 75%), and (3) the phenotypic correlation between early adolescent problem behavior and disinhibitory psychopathology was strong (approximately 0.60) and accounted for primarily by genetic factors common to the two domains. Findings are discussed in the context of research on the prevention and developmental nature of substance use disorders and related psychopathology. KeywordsAdolescent problem behavior; disinhibitory psychopathology; externalizing; twin studies Behavioral genetic research has established the importance of both heritable and non-heritable influences on the development of adult substance use disorders (SUDs) including: nicotine dependence (Heath and Madden, 1995;Kendler et al., 1999), alcohol dependence Kendler et al., 1992;McGue, 1999;, and illicit substance abuse and dependence (Ball and Collier, 2002;Kendler and Prescott, 1998;Lynskey et al., 2002;McGue et al., 2000;Tsuang et al., 1996). Current behavioral genetic research aims to build on these findings by identifying the specific genetic and environmental factors that affect SUD risk and by characterizing their joint mechanisms of actions (Rutter et al., 2001). While much of this effort appropriately involves the use of molecular approaches to identify the specific genes that contribute to SUD risk (Goldman et al., 2005), complementary approaches * To whom correspondence should be addressed at Department of Psychology, University of Minnesota, 75 East River Rd., Minneapolis, MN, 55455, USA. Tel.: +612-625-8305; Fax: +612-626-2079; e-mail: mcgue001@umn.edu. An observation critical to understanding the developmental nature of SUD...

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Genetic influences onDSM-III-R drug abuse and dependence: A study of 3,372 twin pairs

Cited by 433 publications

References 13 publications

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

The Association of Early Adolescent Problem Behavior and Adult Psychopathology: A Multivariate Behavioral Genetic Perspective

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