Genetic influences on the spontaneous EEG: An examination of 15‐year‐old and 17‐year‐old twins

McGuire, Kathryn A.; Iacono, William G.

doi:10.1080/87565649809540698

Cited by 24 publications

(14 citation statements)

References 21 publications

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“…Our study also confirms that bipolar EEG power is a very heritable complex trait in human subjects, confirming the results from previous studies of monopolar EEG power from small twin samples (Lykken et al 1982;McGuire et al 1998;Christian et al 1996), a large twin study (Smit et al 2005) and adolescent studies (van Beijsterveldt and van Baal 2002;van Beijsterveldt et al 1996). The present findings also suggest that bipolar EEG spectral power measures have value in indicating the topographic variability in the genetics of EEG production, a variability which monopolar measures are unlikely to reveal.…”

Section: Discussionsupporting

confidence: 93%

Heritability of Bipolar EEG Spectra in a Large Sib-pair Population

et al. 2006

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The additive genetic heritability of both monopolar and bipolar EEG spectral power in a sample of 305 non-twin sibships comprising 690 individuals (age range 7-65) was estimated in order to investigate their regional variation. The heritabilities of the bipolar EEG spectral power ranged from 0.10 to 0.63 in 38 electrode-pairs, and those of monopolar power ranged from 0.23 to 0.68 in 19 electrodes in six frequency bands from theta to high beta. The bipolar data shows significantly greater topographic variation compared to that of the monopolar data. The mean of bivariate genetic correlations were consistently lower for the bipolar data and the coefficients of variation consistently higher when compared to those of the monopolar data for each of the frequency bands. The results from the bipolar derivations are in greater accord with genetic findings in brain anatomy and show the possibility of multiple genetic sources for the phenotypic variability of EEG activity.

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Section: Discussionsupporting

confidence: 93%

Heritability of Bipolar EEG Spectra in a Large Sib-pair Population

et al. 2006

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“…While most studies did not perform repeat testing to examine test-retest reliability of their EEG findings, the test-retest reliability of the quantified EEG signal has been reasonably well established (47)(48). It is of interest that in some studies the correlation coefficient is higher in schizophrenia patients r=0.94 than healthy controls with r=0.70 (49).…”

Section: Nomentioning

confidence: 99%

The status of spectral EEG abnormality as a diagnostic test for schizophrenia

Boutros

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Galderisi³

et al. 2008

Schizophrenia Research

267

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Objective-A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia.Methods-Fifty three papers met criteria for inclusion into the review and 15 were included in a meta-analysis of the degree of significance of EEG deviations as compared to healthy controls. Studies were classified based on a 4-step approach based on guidelines for evaluating the clinical usefulness of a diagnostic test.Results-Our review and meta-analysis revealed that most of the abnormalities are replicated in the expected directions with the most consistent results related to the increased preponderance of slow rhythms in schizophrenia patients. This effect remained consistent in un-medicated patients. Only a small number of studies provided data on the sensitivity and specificity of the findings in differentiating among the psychiatric disorders that frequently appear on the same differential diagnostic list as schizophrenia (step 3 studies). No multicenter studies using standardized assessment criteria were found (step 4 studies). Conclusions-AdditionalStep 3 and Step 4 studies are needed to draw conclusions on the usefulness of EEG spectral abnormalities as a diagnostic test for schizophrenia

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“…Biometric models derived from twin data have been used to examine genetic and environmental contributions to various psychopathologies, including the spectrum of childhood externalizing disorders (Burt et al, 2001), ADHD (Sherman et al, 1997a(Sherman et al, , 1997b, and substance use disorders , as well as behaviors and traits related to psychopathology such as substance use (Han et al, 1999), eating behavior (Klump et al, 2000(Klump et al, , 2001, state and trait anxiety (Legrand et al, 1999a), delinquency (Taylor et al, 2000a(Taylor et al, , 2000b, and parent-child relationships (Elkins et al, 1997b). Several reports illustrate the heritability and sensitivity to development of various candidate endophenotypes, including spontaneous EEG (McGuire et al, 1998), smooth pursuit eye tracking (Katsanis et al, , 2000, antisaccade eye tracking (Malone & Iacono, in press), eye-blink startle , P300 (Katsanis et al, 1996), and spatial working memory (Zald & Iacono, 1998).…”

Section: Other Findingsmentioning

confidence: 99%

Minnesota Twin Family Study

Iacono¹,

McGue²

2002

twin res

Self Cite

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111

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T he Minnesota Twin Family Study is a longitudinal study of 11-year-old and 17-year-old twins and their parents designed to examine factors related to the etiology of substance abuse and related problems. At study intake, the twins and their parents participate in a day-long assessment in our laboratory that includes measures of endophenotypes (e.g., event-related potentials, EEG, autonomic nervous system reactivity, startle eye-blink), psychopathology, personality, cognitive ability, anthropometry, and environmental risk/protective factors. DNA derived from blood is also collected. A parallel longitudinal study of adolescent adoptive siblings, biologically related siblings, and their parents is also underway. Over 1500 twin families and 350 adoptive and biological sibling families have already entered the longitudinal phase of the study. This article provides an overview of study methods, highlights published findings, and describes procedures in place to foster collaboration with other investigators.Originating over 10 years ago, the Minnesota Twin Family Study (MTFS) is an ongoing population-based, longitudinal investigation of same-sex twin children and their parents that examines the etiology of substance use disorders from a developmental, behavior genetic perspective. Much of the focus of the MTFS is on the notion that an inherited predisposition to develop these disorders is expressed in early adolescence through undersocialized or disinhibited behavior. We further hypothesize that this predisposition is manifest in psychophysiological markers derived from tasks that tap individual differences in inhibitory control. A comprehensive overview of the project along with a summary of early findings can be found in Iacono et al. (1999). Twin RecruitmentTwo age cohorts are included, preadolescent twins recruited at approximately age 11, when they are in grades 5 or 6, and late adolescent twins, recruited at approximately age 17, during their last year in secondary school. Because we rely on publicly available Minnesota birth certificates to identify twins, only those born in Minnesota were eligible for study inclusion. This statewide sample is broadly representative of the Minnesota population. About 60% of the sample come from the seven counties that compose the Minneapolis-St. Paul urban area. The remainder live in smaller cities, towns and rural areas throughout the state and in towns in neighboring states that border Minnesota. Reflecting the ethnic composition of the state at the time they were born, almost all the twins are Caucasian (over 95%), with the majority having German and Scandinavian ancestry.At study intake, the twins, together with their parents, travel from around the state to spend a day in our university laboratory. The day is split between interviews with all four family members and time in the psychophysiology laboratory. This procedure, with some variations, is repeated every three to four years. Because the first twins were assessed in 1991, some of the twins who were 11 at study intake...

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Genetic influences on the spontaneous EEG: An examination of 15‐year‐old and 17‐year‐old twins

Cited by 24 publications

References 21 publications

Heritability of Bipolar EEG Spectra in a Large Sib-pair Population

Heritability of Bipolar EEG Spectra in a Large Sib-pair Population

The status of spectral EEG abnormality as a diagnostic test for schizophrenia

Minnesota Twin Family Study

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