Genetic influence on bone mineral density in Korean twins and families: the healthy twin study

Park, J.-H.; Song, Yun-Mi; Sung, Joohon; Lee, K.; Kim, Y. S.; Park, Y. S.

doi:10.1007/s00198-011-1685-z

Cited by 28 publications

(17 citation statements)

References 38 publications

(90 reference statements)

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“…Whereas Korean males showed the highest heritability (0.76) in lumbar BMD, the heritability of lumbar BMD (0.66) was relatively low compared to pelvic BMD (0.78) in females 53 . We cannot exactly understand the reason for and clinical significance of this finding.…”

Section: Discussionmentioning

confidence: 87%

Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with Femoral Neck Bone Mineral Density in Postmenopausal Women

Kim

Lee²

2012

J Rheumatol

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Section: Discussionmentioning

confidence: 87%

Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with Femoral Neck Bone Mineral Density in Postmenopausal Women

Kim

Lee²

2012

J Rheumatol

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“…Quando utilizado o DXA, são encontrados resultados semelhantes, havendo maior correlação da DMO entre os gêmeos monozigóticos e menor correlação entre pais e filhos, demonstrando que 51-76% da variação na DMO é hereditária 39. Mais estudos são necessários em relação aos fatores genéticos, uma vez que as pesquisas com esse enfoque demonstraram haver afinidade genética em relação à massa óssea em gêmeos monozigóticos e dizigóticos, com diferenças preditas pelas variáveis antropométricas.…”

Section: Genéticaunclassified

Fatores que influenciam a massa óssea de crianças e adolescentes saudáveis mensurada pelo ultrassom quantitativo de falanges: revisão sistemática

Krahenbühl

Gonçalves

Costa

et al. 2014

Revista Paulista de Pediatria

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Objective:To analyze the main factors that influence bone mass in children and teenagers assessed by quantitative ultrasound (QUS) of the phalanges. Data source:A systematic literature review was performed according to the PRISMA method with searches in databases Pubmed/Medline, SciELO and Bireme for the period 2001-2012, in English and Portuguese languages, using the keywords: children, teenagers, adolescent, ultrasound finger phalanges, quantitative ultrasound of phalanges, phalangeal quantitative ultrasound. Data synthesis:21 articles were included. Girls had, in QUS, Amplitude Dependent Speed of Sound (AD-SoS) values higher than boys during pubertal development. The values of the parameters of QUS of the phalanges and dual-energy X-ray Absorptiometry (DXA) increased with the increase of the maturational stage. Anthropometric variables such as age, weight, height, body mass index (BMI), lean mass showed positive correlations with the values of QUS of the phalanges. Physical activity has also been shown to be positively associated with increased bone mass. Factors such as ethnicity, genetics, caloric intake and socioeconomic profile have not yet shown a conclusive relationship and need a larger number of studies. Conclusions:QUS of the phalanges is a method used to evaluate the progressive acquisition of bone mass during growth and maturation of individuals in school phase, by monitoring changes that occur with increasing age and pubertal stage. There were mainly positive influences variables of sex, maturity, height, weight and BMI, with similar data when compared to the gold standard method, the DXA.

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“…This disease accounts for approximately 1.5 million new fracture cases each year, representing a huge economic burden on health care systems, with annual costs estimated to be $17 billion in the United States alone and expected to rise 50% by the year 2025 1 , 2 . Osteoporosis is mainly characterized by bone fragility (most individuals have a low BMD) and it is a highly heritable trait with heritability ranging from 0.5 to 0.8 3 . Recent studies have shown that multiple genetic variants in Wnt pathway components including AXIN1 , CTNNB1 , DKK1 , LRP4 , LRP5 , MEF2C , RSPO3 , SFRP4 , SOST , WLS , WNT3 , WNT4 , WNT5B and WNT16 are associated with BMD 4 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish

Wang

Salimi

Deng

et al. 2018

Sci Rep

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Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density (BMD) in human. The aim of this study is to investigate the role of genetic variation in WISP1 gene as a determinant of BMD in 1,510 Old Order Amish (OOA). We performed regional association analysis of 58 tag variants within 5 kb upstream and downstream to WISP1 with BMD and found 5 variants that were associated with BMD at multiple skeletal sites (P values from 2.89 × 10−6 to 1.62 × 10−2), with some significant associations even after adjustment for multiple comparisons. To replicate these results in an independent dataset, we performed a look-up of BMD associations with these variants in European ancestry subjects from the large GEFOS Consortium and observed the nominal associations of two of these variants with BMD (P values: 0.031 to 0.048). In conclusion, we have demonstrated that genetic variants surrounding WISP1 are associated with BMD at multiple skeletal sites in the OOA, thus influencing osteoporosis risk. These results support a role for the WISP1 gene on influencing variation in BMD.

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Genetic influence on bone mineral density in Korean twins and families: the healthy twin study

Abstract: The high heritability of BMD in this Korean population similar to those found in Western populations and the significant common genetic basis between BMDs at different sites strongly supports a significant role of genetic determinants on the risk of osteoporosis.

Cited by 28 publications

References 38 publications

Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with Femoral Neck Bone Mineral Density in Postmenopausal Women

Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with Femoral Neck Bone Mineral Density in Postmenopausal Women

Fatores que influenciam a massa óssea de crianças e adolescentes saudáveis mensurada pelo ultrassom quantitativo de falanges: revisão sistemática

Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish

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