Genetic influence of Apolipoprotein E gene ε2/ε3/ε4 isoforms on odds of mesial temporal lobe epilepsy

Abstract

Objective: The potential correlation between the ε2/ε3/ε4 variants of the ApoE (Apolipoprotein E) gene and the odds of mesial temporal lobe epilepsy was investigated.
 Methods: The database searching for eligible studies was performed in October 2020. A series of pooling analyses were conducted.
 Results: We enrolled a total of twelve case-control studies for pooling. Within the pooling analysis of ε4, there was an in- creased risk of mesial temporal lobe epilepsy in cases under the models of carrier ε4 vs. ε3, ε3ε4 vs. ε3ε3, and ε3ε4+ε4ε4 vs. ε3ε3 [P < 0.05, odds ratio (OR) > 1], compared with controls. Moreover, we observed similar positive results in the subgroup analyses of “China” and “Population-based control” under the genetic models of ε4 (P < 0.05, OR > 1). Nevertheless, we did not detect the significant difference between the mesial temporal lobe epilepsy cases and controls in the pooling analyses of ε2 (all P > 0.05).
 Conclusion: The ε3ε4 genotype of ApoE seems to be linked to the risk of mesial temporal lobe epilepsy for patients in China. More sample sizes are required to confirm the potential role of ApoE isoforms in the susceptibility to diverse types of epilepsy from different origins.
 Keywords: Epilepsy; ApoE; isoforms; susceptibility.

Molecular Genetics of Acquired Temporal Lobe Epilepsy

“…Specific polymorphisms of schizophrenia-related gene DTNBP1 (dystrobrevin-binding protein 1) were found to either increase or reduce the risk for TLE [ 163 ]. The apolipoprotein E ε4 genotype seems to be associated with an increased risk of MTLE [ 164 , 165 ]. These studies have strengthened the idea that genetic variations in epileptogenesis-associated genes and pathways can act as risk factors for the development of acquired TLE.…”

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“… 44 A case report on refractory convulsive syncope in pregnancy and Takayasu's arteritis 45 ends that brief section on sexuality. Some reflections on mental health include: effects of black tea consumption on depression 46 ; genetic influence of Apolipoprotein E gene ε2/ε3/ε4 isoforms on odds of mesial temporal lobe epilepsy 47 ; and correlates of substance use among undergraduates in a low income country. 48 A rare paper on ‘psychological ailments and their treatment protocols based on a study of Swati traditional healers in Mpumalanga Province, in South Africa concludes the mental health section.…”