Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish
Wenqing Li,
Sara McCurdy,
Miguel A. Lopez-Ramirez
et al.
Abstract:Propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (CVP) lesions in zebrafish that follow mosaic inactivation of ccm2. Because morpholino silencing of the β1 adrenergic receptor (adrb1) prevents the embryonic CVP lesion, we proposed that adrb1 plays a role in CCM pathogenesis. Here we report that adrb1-/- zebrafish exhibited 86.80% fewer CVP lesions and 87.34% reduction of CCM lesion volume relative to wild type brood mates at 2dpf and 8-… Show more
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