Genetic Heterogeneity of Delta-Aminolevulinate Dehydrase and Phosphoglycolate Phosphatase in North-West Spain

Abstract

The distribution of △-aminolevulinate dehydrase and phosphoglycolate phosphatase phenotypes was analyzed in 500 autochthonous individuals from the Galician population (north-west Spain). The gene frequencies for PGP² and ALADH² obtained in Galicia have proved to be the lowest of all the European populations so far examined. Comparisons with other world populations were also made.

Human Enzyme Polymorphism in the Canary Islands

“…In the Berber sample an electrophoretic variant with normal activity and with the same No significant gene frequency differences were found between our and other Spanish samples studied for the same loci by Afonso et al [81,Brinkmann et al [18], Caeiro and Rcy [19], Carracedo and Concheiro [20], Goedde et al [21], except for the ACP-1 gene [8], where our sample had a lower ACP-A frequency (X2 = 7.18; d.f. = 2; p < 0.05).…”

Human Enzyme Polymorphism on the Canary Islands

“…As it seems to differ from other rare variants previously described, we desig nated it C' (table I). Allele 3 of the PGP lo cus, which is usually reported with a fre quency of 0.026 in Spanish populations [ Caeiro and Rey, 1985] has not, however, been detected in this work. This could be due to the relatively small sample size.…”

Phosphoglycolate Phosphatase Polymorphism: Gene Frequencies in Three Italian Samples

“…The possible existence of a gradient in PGP gene frequencies from Northern to Southern Europe was noted by a number of authors [Brink et al, 1981;Caeiro and Rey, 1985]. Together with these observa tions, present Findings led us to correlate the PGP1 allele frequencies obtained in this survey, together with those already available for other European populations, with the latitude of the places where the corresponding populations were from ( fig.…”

“…North-South cline in frequency of PGP1 allele in human populations from Europe and Tur key. Key to geographic areas: I = Sicily ; 2 = Cagliari [this paper]; 3 = Turkey [Bas ler et al, 1983]; 4 = Naples [Ranzani et al, 1982]; 5 -Rome [this paper]; 6 = Galicia [Caeiro and Rey, 1985]; 7 = Viareggio [this paper]; 8 = Po Delta [Beretta et al, 1981]; 9 = Lombardy [Barberio et al, in preparation]; 10 *» Switzerland [Scherz et al, 1981]; 11 = South-Western Germany [Amorim et al, 1980]; 12 -Bonn [Brink et al, 1981]; 13 = Düsseldorf [Bas ler et al, 1983]; 14 = Berlin [Radam and Strauch, 1982]; 15 = West Berlin [Martin et al, 1981]; 16 -Schleswig-Holstein [Christiansen and Sachs, 1981]; 17 = Finland (Barker and Hopkinson, 1978]. The weighted regression line has the equation: y = 1.212-0.007x; correlation coefficient, r = 0.96; p <0.001. lation above 0.4.…”