Genetic Heterogeneity and Recombination in Human Type 2 Astroviruses

Grazia, Simona De; Medici, Maria-Cristina; Pinto, Pierfrancesco; Moschidou, P.; Tummolo, Fabio; Calderaro, Adriana; Bonura, Floriana; Bányai, Krisztiàn; Giammanco, Anna; Martella, Vito

doi:10.1128/jcm.02102-12

Cited by 33 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recombinations between different animal AstVs have also been described (152,155,162,183). Although most recombination breakpoints have been identified upstream of the conserved ORF1b/ORF2 junction region (155,168,172,182), they are also frequent within ORF2 (152,155,172,177), and they may also exist within ORF1a (155,181) and ORF1b (155,177,180).…”

Section: Figmentioning

confidence: 99%

Human Astroviruses

2014

View full text Add to dashboard Cite

SUMMARY Human astroviruses (HAtVs) are positive-sense single-stranded RNA viruses that were discovered in 1975. Astroviruses infecting other species, particularly mammalian and avian, were identified and classified into the genera Mamastrovirus and Avastrovirus . Through next-generation sequencing, many new astroviruses infecting different species, including humans, have been described, and the Astroviridae family shows a high diversity and zoonotic potential. Three divergent groups of HAstVs are recognized: the classic ( MAstV 1 ), HAstV-MLB ( MAstV 6 ), and HAstV-VA/HMO ( MAstV 8 and MAstV 9 ) groups. Classic HAstVs contain 8 serotypes and account for 2 to 9% of all acute nonbacterial gastroenteritis in children worldwide. Infections are usually self-limiting but can also spread systemically and cause severe infections in immunocompromised patients. The other groups have also been identified in children with gastroenteritis, but extraintestinal pathologies have been suggested for them as well. Classic HAstVs may be grown in cells, allowing the study of their cell cycle, which is similar to that of caliciviruses. The continuous emergence of new astroviruses with a potential zoonotic transmission highlights the need to gain insights on their biology in order to prevent future health threats. This review focuses on the basic virology, pathogenesis, host response, epidemiology, diagnostic assays, and prevention strategies for HAstVs.

show abstract

Section: Figmentioning

confidence: 99%

Human Astroviruses

2014

View full text Add to dashboard Cite

show abstract

“…As previously reported, the ORF1b/ORF2 region was known as a crossover point [ 22 – 24 ]. There were several appearance of recombination event occurred in this region from different lineages or among same serotype [ 23 – 26 ]. Unfortunately, we failed to amplify the whole genome of CAstVs, as it was hard to evaluate the actual origin or recombination with other species.…”

mentioning

confidence: 99%

“…So far, there are over 80 avian and mammalian host species detected in many species, which leads to its large diversity [ 27 ]. Generally, the majority of AstVs naturally infect only related host species, or more than one lineage could transmit in a single host [ 23 , 28 ]. Whether this recombination event or cross-species transmission will emerge in CAstVs should raise corncens.…”

mentioning

confidence: 99%

Detection and genetic characterization of canine astroviruses in pet dogs in Guangxi, China

Zhou

Liu

et al. 2017

Virol J

View full text Add to dashboard Cite

BackgroundAstroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species. Human AstVs were regarded the causative agent of viral diarrhea in children. In dogs, little is known about the epidemiology and clinical significance of AstV infection.FindingsIn this study, we collected and tested 253 rectal swabs from pet dogs; of which 64 samples (25.3%) tested positive for AstVs with diarrhea and 15 more samples (5.9%) also was identified as AstVs, however without any clinical signs. Phylogenetic analysis of 39 partial ORF1b sequences from these samples revealed that they are similar to AstVs, which can be subdivided into three lineages. Interestingly, out of the 39 isolates sequenced, 16 isolates are shown to be in the Mamastrovirus 5/canine astrovirus (CAstV) lineage and the remaining 23 isolates displayed higher similarities with known porcine astrovirus (PoAstV) 5 and 2. Further, analysis of 13 capsid sequences from these isolates showed that they are closely clustered with Chinese or Italy CAstV isolates.ConclusionsThe findings indicate that CAstVs commonly circulate in pet dogs, and our sequencing results have shown the genomic diversity of CAstVs leading to increasing number of clusters.

show abstract

“…1). Virus recombination has also been reported to drive the increasing genomic diversity of this virus family (3,4), which may arise from infection of individuals with multiple virus strains belonging to different lineages, although reporting of multiple infections is poor. Systematic astrovirus surveillance in swine in the United States revealed a high proportion of pigs (13.9%) coinfected with viruses from two or more porcine astrovirus lineages (5), signifying the potential for recombination.…”

mentioning

confidence: 99%

Ecological Drivers of Virus Evolution: Astrovirus as a Case Study

Mendenhall

Smith

Vijaykrishna

2015

J Virol

View full text Add to dashboard Cite

Although RNA viruses exhibit a high frequency of host jumps, major differences exist among the different virus families. Astroviruses infect a wide range of hosts, affecting both public health systems and economic production chains. Here we delineate the ecological and adaptive processes that drive the cross-species transmission of astroviruses. We observe that distinct transmission zones determine the prevailing astrovirus host and virus diversity, which in turn suggests that no single host group (e.g., bats) can be the natural reservoir, as illustrated through our phylogenetic analysis. SCALABLE HEIGHTS: FROM EVOLUTION TO ECOSYSTEM

show abstract

Genetic Heterogeneity and Recombination in Human Type 2 Astroviruses

Cited by 33 publications

References 25 publications

Human Astroviruses

Human Astroviruses

Detection and genetic characterization of canine astroviruses in pet dogs in Guangxi, China

Ecological Drivers of Virus Evolution: Astrovirus as a Case Study

Contact Info

Product

Resources

About