Abstract:Fine-mapping is an analytical step to perform causal prioritization of the polymorphic variants on a trait-associated genomic region observed from genome-wide association studies (GWAS). The prioritization of causal variants can be challenging due to the linkage disequilibrium (LD) patterns among hundreds to thousands of polymorphisms associated with a trait. We propose a novel ℓ0 graph norm shrinkage algorithm to select causal variants from dense LD blocks consisting of highly correlated SNPs that may not be … Show more
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