“…In OMS-associated neuroblastoma, tumors usually do not have MYCN amplification and have aneuploid DNA content, although MYCN oncogene amplification and hyperdiploid tumors have also been reported. 6,8,[13][14][15] Numerical chromosome alterations (NCA) and segmental chromosome alterations (SCA), such as the gain of chromosomes 1q, 2p, and 17q and deletion of 1p, 3p, 11q, and 14q, are usually observed in neuroblastoma. 14,[16][17][18][19] NCA is often observed in children with localized tumors and favorable outcomes, whereas SCA is more frequently observed in children with advanced stages and poorer prognoses.…”