J. Neurosci. Res. volume 86, issue 16, P3494-3502 2008 DOI: 10.1002/jnr.21862 View full text
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Kouko Tatsumi, Hirohide Takebayashi, Takayuki Manabe, Kenji F. Tanaka, Manabu Makinodan, Takahira Yamauchi, Eri Makinodan, Hiroko Matsuyoshi, Hiroaki Okuda, Kazuhiro Ikenaka, Akio Wanaka

Abstract: Olig2 is a basic helix-loop-helix (bHLH) transcription factor essential for development of motoneurons and oligodendrocytes. It is known that Olig2(+) cells persist in the central nervous system (CNS) from embryonic to adult stages and that the number of Olig2(+) progenitors increases in the injured adult CNS. Recent studies have demonstrated an inhibitory action of Olig2 on neurogenesis in adult CNS, but the fate of Olig2(+) cells in the injured state remains largely unknown. To trace directly the fate of Oli…

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