Genetic factors underlying insomnia and ovarian insufficiency

Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice

“…Studies in patients with poor ovarian response (POR) have shown that this disfunction is related to nicotinate and NAM metabolic pathways and appears to impact the ovarian reserve 66 . Moreover, NAM is very important for oocyte maturation, it is involved in the salvage pathway of NAD + synthesis in cumulus cells, and is increased substantially throughout the course of oocyte maturation 67 . We speculate that the mitochondrial disfunction observed in oocytes can be due, at least in part, to a decrease in NAM availability.…”