Genetic Factors that Influence HIV Infection: The Role of the Major Histocompatibility Complex System

HIV mother-to-child transmission: A complex genetic puzzle tackled by Brazil and Argentina research teams

“…This class of genes has been so far investigated for its role in the infection of HIV and MTCT. Several polymorphisms in HLA genes have been widely studied as candidates for susceptibility to MTCT (Kilpatrick et al, 1991;Greggio et al, 1993;Winchester et al, 1995;Aikhionbare et al, 2001;Fabris et al, 2009;Segat et al, 2009b;Pérez-Núñez et al, 2011).…”

“…Another study showed that the concordance or discordance of HLA alleles between mother and child could to be a key factor for MTCT, and that HLA genotype could influence disease susceptibility in utero by affecting immune responses (Pérez-Núñez et al, 2011).…”