Genetic Factors in Tendon Injury: A Systematic Review of the Literature

Vaughn, Natalie H.; Stepanyan, Hayk; Gallo, Robert A.; Dhawan, Aman

doi:10.1177/2325967117724416

Cited by 29 publications

(23 citation statements)

References 56 publications

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“…110 III Systematic reviews found that gene variants influenced the development of Achilles tendinopathy. 108,202 Specifically, genes associated with the collagen-production pathway may functionally affect tendon strength and stiffness, leading to an abnormal tendon response to loading. This was supported by other studies not included in this review.…”

Section: IImentioning

confidence: 99%

Achilles Pain, Stiffness, and Muscle Power Deficits: Midportion Achilles Tendinopathy Revision 2018

Martin¹,

Chimenti²,

Cuddeford³

et al. 2018

Journal of Orthopaedic & Sports Physical Therapy

171

180

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The Orthopaedic Section of the American Physical Therapy Association (APTA) has an ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy management of patients with musculoskeletal impairments described in the World Health Organization's International Classification of Functioning, Disability, and Health (ICF). The purpose of these revised clinical practice guidelines is to review recent peer-reviewed literature and make recommendations related to midportion Achilles tendinopathy. J Orthop Sports Phys Ther 2018;48(5):A1–A38. doi:10.2519/jospt.2018.0302

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Section: IImentioning

confidence: 99%

Achilles Pain, Stiffness, and Muscle Power Deficits: Midportion Achilles Tendinopathy Revision 2018

Martin¹,

Chimenti²,

Cuddeford³

et al. 2018

Journal of Orthopaedic & Sports Physical Therapy

171

180

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“…Nutrients penetrate through semipermeable membranes to promote the repair of injured cells and effectively enhance the endogenous healing of tendons. bFGF, HGF, and TGF- β 1 promote the differentiation, transformation, proliferation, and migration of stem cells and inhibit the growth of TGF- β receptors, which can prohibit the proliferation and differentiation of fibroblasts; downregulate the expression of α -smooth muscle actin, fibronectin, and integrin; reduce the biological function of fibroblasts and decrease fibrosis and scar formation [26, 27].…”

Section: Discussionmentioning

confidence: 99%

Biological Amnion Prevents Flexor Tendon Adhesion in Zone II: A Controlled, Multicentre Clinical Trial

Liu

Bai

et al. 2019

BioMed Research International

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Introduction. Tendon adhesion to surrounding tissues is the most common complication reported after tendon repair. To date, effective solutions to prevent tendon injury are still lacking. Materials and Methods. A total of 89 patients with flexor tendon injury in zone II were recruited. The patients were divided into a control group, a poly-DL-lactic acid (PDLLA) group, and an amnion group according to the different tendon treatments applied. The control group was not subjected to other treatments. PDLLA and bioamniotic membranes were, respectively, used to wrap broken ends in the PDLLA and amnion membrane groups. The patients were followed at 1, 2, 3, 6, and 12 months after surgery and the ranges of active flexion and extension lag in the proximal and distal interphalangeal joints were evaluated. Results. The means of total active ranges of motion of the interphalangeal joints (excluding rupture cases) in the PDLLA and amnion groups did not significantly differ between each other but significantly differed from that of the control group. Statistical analysis showed a significant difference in the clinical grades of the outcomes among the control, PDLLA, and amnion groups. The incidence of complications in the control and PDLLA groups was found to be significantly higher than that in the amniotic membrane group; no significant difference was observed between the control and PDLLA groups. Conclusion. In this study, freeze-dried amniotic membrane transplantation was applied to promote healing of the flexor tendon in zone II and prevent adhesion. This technique presents a new method to solve the issue of tendon adhesion after repair. Clinical Trial Registration. The trial was registered by identifier ChiCTR1900021769.

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“…Previous etiologic studies have indicated that environmental factors and self-diseases play important roles in the occurrence and development of chronic AT, such as age over 60 years, overuse, renal failure and diabetes mellitus 3 . Nevertheless, many case-control studies have found significant association signals between single nucleotide polymorphisms (SNPs) and chronic AT in Europeans 4–7 . Since chronic AT is a multifactorial disease with a complex genetic component, additional candidate genes should be investigated.…”

Section: Introductionmentioning

confidence: 99%

Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy

Kang

Tian

Zhang

et al. 2019

Sci Rep

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Previous etiologic studies have indicated that both environmental and genetic factors play important roles in the occurrence and development of chronic Achilles tendinopathy (AT). A recent study documented the results of the largest genome-wide association study for chronic AT to date, indicating that MPP7, TIMP2 and CASP8 may be involved in the occurrence and development of chronic AT. In this study, we aimed to investigate whether MPP7, TIMP2 and CASP8 were associated with susceptibility to chronic AP in a Han Chinese population. A total of 3,680 study subjects comprised 1,288 chronic AT cases, and 2,392 healthy controls were recruited. Forty-four tag SNPs (7 from CASP8, 20 from MPP7, and 17 from TIMP2) were genotyped in the study. Genetic association analyses were performed at both single marker and haplotype levels. Functional consequences of significant SNPs were examined in the RegulomeDB and GTEx databases. Two SNPs, SNP rs1937810 (OR [95%CI] = 1.20 [1.09–1.32], χ2 = 13.50, P = 0.0002) in MPP7 and rs4789932 (OR [95%CI] = 1.24 [1.12–1.37], χ2 = 17.98, P = 2.23 × 10−5) in TIMP2, were significantly associated with chronic AT. Significant eQTL signals for SNP rs4789932 on TIMP2 were identified in human heart and artery tissues. Our results provide further supportive evidence for the association of the TIMP2 and MPP7 genes with chronic AT, which supports important roles for TIMP2 and MPP7 in the etiology of chronic AT, adding to the current understanding of the susceptibility of chronic AT.

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Genetic Factors in Tendon Injury: A Systematic Review of the Literature

Cited by 29 publications

References 56 publications

Achilles Pain, Stiffness, and Muscle Power Deficits: Midportion Achilles Tendinopathy Revision 2018

Achilles Pain, Stiffness, and Muscle Power Deficits: Midportion Achilles Tendinopathy Revision 2018

Biological Amnion Prevents Flexor Tendon Adhesion in Zone II: A Controlled, Multicentre Clinical Trial

Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy

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