Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets?
Alfonso Martone,
Chiara Possidente,
Giuseppe Fanelli
et al.
Abstract:Treatment response and resistance in major depressive disorder (MDD) show a significant genetic component, but previous studies had limited power also due to MDD heterogeneity. This literature review focuses on the genetic factors associated with treatment outcomes in MDD, exploring their overlap with those associated with clinically relevant symptom dimensions. We searched PubMed for: (1) genome-wide association studies (GWASs) or whole exome sequencing studies (WESs) that investigated efficacy outcomes in MD… Show more
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