Genetic Evolution of H9 Subtype Influenza Viruses from Live Poultry Markets in Shanghai, China

Ge, Fei-Fei; Zhou, Jinlin; Liu, Jian; Wang, Jian; Zhang, Weiyi; Sheng, Li‐Ping; Feng, Xin; Ju, Hou-Bing; Sun, Qiangming; Liu, Peihong

doi:10.1128/jcm.00355-09

Cited by 44 publications

(39 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since 1997, H9N2 viruses have been reported in multiple avian species throughout Asia, the Middle East, Europe, and Africa (1,2,6,14,15,16,17,18,22,23,28,44,50) and have occasionally been transmitted from poultry to mammalian species, including humans and pigs (5,24,32). Further evidence of an expanded mammalian host range includes efficient replication of H9N2 in experimental mice without adaptation (9).…”

Section: Avian Influenza Viruses Of the H9n2 Subtype Have Seriously Amentioning

confidence: 99%

“…Further evidence of an expanded mammalian host range includes efficient replication of H9N2 in experimental mice without adaptation (9). Numerous recent H9N2 isolates contain the amino acid leucine at position 226 (L226) in their hemagglutinin (HA) receptor-binding site (RBS), which exhibits preferential binding to human-like ␣2-6-linked sialic acid (SA␣2-6) receptors and is regarded as one of the key elements in the successful infection of humans (14,18,24,45,50). Recent research using ferrets demonstrated that L226-containing H9N2 viruses were more likely to be transmitted, although no aerosol transmission was observed (44).…”

Section: Avian Influenza Viruses Of the H9n2 Subtype Have Seriously Amentioning

confidence: 99%

See 1 more Smart Citation

Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications

Fusaro

Monne

Salviato

et al. 2011

J Virol

149

153

View full text Add to dashboard Cite

Avian influenza viruses of the H9N2 subtype have seriously affected the poultry industry of the Far andMiddle East since the mid-1990s and are considered one of the most likely candidates to cause a new influenza pandemic in humans. To understand the genesis and epidemiology of these viruses, we investigated the spatial and evolutionary dynamics of complete genome sequences of H9N2 viruses circulating in nine Middle Eastern and Central Asian countries from 1998 to 2010. We identified four distinct and cocirculating groups (A, B, C, and D), each of which has undergone widespread inter-and intrasubtype reassortments, leading to the generation of viruses with unknown biological properties. Our analysis also suggested that eastern Asia served as the major source for H9N2 gene segments in the Middle East and Central Asia and that in this geographic region within-country evolution played a more important role in shaping viral genetic diversity than migration between countries. The genetic variability identified among the H9N2 viruses was associated with specific amino acid substitutions that are believed to result in increased transmissibility in mammals, as well as resistance to antiviral drugs. Our study highlights the need to constantly monitor the evolution of H9N2 viruses in poultry to better understand the potential risk to human health posed by these viruses.

show abstract

Section: Avian Influenza Viruses Of the H9n2 Subtype Have Seriously Amentioning

confidence: 99%

Section: Avian Influenza Viruses Of the H9n2 Subtype Have Seriously Amentioning

confidence: 99%

Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications

Fusaro

Monne

Salviato

et al. 2011

J Virol

149

153

View full text Add to dashboard Cite

show abstract

“…H9N2 viruses of each of the three sublineages, G1, Y280, and Korean, were recently isolated from wildbirds and poultry worldwide [3,6,27]. H9N2 viruses were also isolated from pigs and humans in China [4,5,37] and Korea, suggesting that these viruses have the potential to cause pandemic influenza in humans.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, H9N2 influenza virus is prevailing poultry populations in Eurasian countries [9][10][11]24]. Since H9N2 viruses were isolated from quails in Hong Kong in 1988, they have become prevalent in live bird markets and poultry farms in Asia [6,32]. The wide spread of H9N2 virus have been greatly concerned not only in the poultry industry but also for public health [6,38].…”

mentioning

confidence: 99%

“…Since H9N2 viruses were isolated from quails in Hong Kong in 1988, they have become prevalent in live bird markets and poultry farms in Asia [6,32]. The wide spread of H9N2 virus have been greatly concerned not only in the poultry industry but also for public health [6,38]. The hemagglutinin (HA) genes of Eurasian H9N2 viruses have been phylogenetically divided into G1, Y280, and Korean sublineages [10].…”

mentioning

confidence: 99%

See 1 more Smart Citation

An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong

Nomura

Sakoda

Soda

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. H9N2 influenza viruses circulate in wild birds and poultry in Eurasian countries, and have been isolated from pigs and humans in China. H9N2 viruses isolated from birds, pigs and humans have been classified into three sublineages based on antigenic and genetic features. Chicken antisera to H9N2 viruses of the Korean sublineage reacted with viruses of different sublineages by the hemagglutination-inhibition test. A test vaccine prepared from a non-pathogenic A/duck/Hokkaido/49/1998 (H9N2) strain of the Korean sublineage, obtained from our influenza virus library, induced immunity in mice to reduce the impact of disease caused by the challenge with A/Hong Kong/1073/1999 (H9N2), which is of a different sublineage. The present results indicate that an inactivated whole virus vaccine prepared from a non-pathogenic influenza virus from the library could be used as an emergency vaccine during the early stage of a pandemic caused by H9N2 infection.

show abstract

Human infection with an avian influenza A (H9N2) virus in the middle region of China

Huang

Zhou

et al. 2015

J. Med. Virol.

View full text Add to dashboard Cite

During the epidemic period of the novel H7N9 viruses, an influenza A (H9N2) virus was isolated from a 7-year-old boy with influenza-like illness in Yongzhou city of Hunan province in November 2013. To identify the possible source of infection, environmental specimens collected from local live poultry markets epidemiologically linked to the human case in Yongzhou city were tested for influenza type A and its subtypes H5, H7, and H9 using real-time RT-PCR methods as well as virus isolation, and four other H9N2 viruses were isolated. The real-time RT-PCR results showed that the environment was highly contaminated with avian influenza H9 subtype viruses (18.0%). Sequencing analyses revealed that the virus isolated from the patient, which was highly similar (98.5-99.8%) to one of isolates from environment in complete genome sequences, was of avian origin. Based on phylogenetic and antigenic analyses, it belonged to genotype S and Y280 lineage. In addition, the virus exhibited high homology (95.7-99.5%) of all six internal gene lineages with the novel H7N9 and H10N8 viruses which caused epidemic and endemic in China. Meanwhile, it carried several mammalian adapted molecular residues including Q226L in HA protein, L13P in PB1 protein, K356R, S409N in PA protein, V15I in M1 protein, I28V, L55F in M2 protein, and E227K in NS protein. These findings reinforce the significance of continuous surveillance of H9N2 influenza viruses.

show abstract

Genetic Evolution of H9 Subtype Influenza Viruses from Live Poultry Markets in Shanghai, China

Cited by 44 publications

References 24 publications

Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications

Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications

An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong

Human infection with an avian influenza A (H9N2) virus in the middle region of China

Contact Info

Product

Resources

About