Genetic evidence for a maternal effect locus controlling genomic imprinting and growth

Duselis, Amanda R.; Wiley, Christopher D.; O’Neill, Michael; Vrana, Paul B.

doi:10.1002/gene.20166

Cited by 22 publications

(26 citation statements)

References 49 publications

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“…First, several loci lose their imprinted status in hybrid embryos and placentas, particularly in the PO × BW offspring (Vrana et al 1998(Vrana et al , 2000. This loss-of-imprinting is modulated by a genetic maternal effect (Duselis et al 2005). Second, we have mapped two loci involved in the overgrowth phenotype to imprinted domains (Vrana et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Duselis

Obergfell

Mack

et al. 2007

Reprod. Fertil. Dev.

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Abstract.Crosses between two species of the rodent genus Peromyscus produce defects in both growth and development. The defects are pronounced in the hybrid placentas. Peromyscuys maniculatus (strain BW) females mated to P. polionotus (strain PO) males produce placentas half the size of the parental species, as well as growth-retarded embryos. In contrast, PO females mated to BW males result in defective conceptuses that display embryonic and placental overgrowth. These 'parent-of-origin'-dependent phenotypes are consistent with previous studies that demonstrated altered expression of imprinted genes and genetic linkage of the overgrowth phenotypes to imprinted domains. In the present study, we take a broader approach in assessing perturbations in hybrid placental gene expression through the use of Mus musculus cDNA microarrays. In verifying classes of genes identified in microarray screens differentially regulated during hybrid placental development, we focused on those influencing the cell cycle and extracellular matrix (ECM). Our work suggests that cell cycle regulators at the G 1 /S phase check-point are downregulated in the large hybrid placenta, whereas the small hybrid placenta is more variable. The ECM genes are typically downstream targets of cell cycle regulation and their misregulation is consistent with many of the dysmorphic phenotypes. Thus, these data suggest imbalances in proliferation and differentiation in hybrid placentation.

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Section: Discussionmentioning

confidence: 99%

Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Duselis

Obergfell

Mack

et al. 2007

Reprod. Fertil. Dev.

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“…Grossniklaus et al 2001;Duselis et al 2005), perhaps through some maternal behaviour ( Weaver et al 2004), then there can be a maternal effect on the pattern of gene expression and imprinting itself would This latter scenario highlights a complicating phenomenon in the analysis of maternal effects, namely, there can be variation in offspring traits that depends on the combination of maternal and offspring genotypes. Although, this appears as a maternal genotype by offspring genotype interaction variance (Wade 1998;Wolf 2000), it is also as a type of maternal effect if the maternal genotype or phenotype is causing a change in the pattern of gene expression or genetic effects in offspring (see below), as in the scenario illustrated in table 3.…”

Section: What Maternal Effects Are Not (A) Maternal Cytoplasmic Inhermentioning

confidence: 99%

What are maternal effects (and what are they not)?

Wolf

Wade

2009

Phil. Trans. R. Soc. B

460

392

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Maternal effects can play an important role in a diversity of ecological and evolutionary processes such as population dynamics, phenotypic plasticity, niche construction, life-history evolution and the evolutionary response to selection. However, although maternal effects were defined by quantitative geneticists well over half a century ago, there remains some confusion over exactly what phenomena should be characterized as maternal effects and, more importantly, why it matters and how they are defined. We suggest a definition of maternal effects as the causal influence of the maternal genotype or phenotype on the offspring phenotype. This definition differs from some definitions in that it treats maternal effects as a phenomenon, not as a statistical construct. The causal link to maternal genotype or phenotype is the critical component of this definition providing the link between maternal effects and evolutionary and ecological processes. We show why phenomena such as maternal cytoplasmic inheritance and genomic imprinting are distinct genetically from and have different evolutionary consequences than true maternal effects. We also argue that one should consider cases where the maternal effect is conditional on offspring genotype as a class of maternal effects.

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“…The latter correlated with aberrant, biallelic expression of the Kcnq1ot1 long noncoding RNA that mediates allelic repression along this imprinted domain, particularly in the placenta. The X chromosome is also genetically linked to the overgrowth phenotype (Vrana et al, 2000;Duselis et al, 2005). In female (P Â M)F 1 embryos, X chromosome inactivation was not random but was heavily skewed towards the paternal X (Vrana et al, 2000).…”

Section: Imprinted Gene Expression In Mammalian Interspecies Hybridsmentioning

confidence: 99%

Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications

2014

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Diverse mechanisms contribute to the evolution of reproductive barriers, a process that is critical in speciation. Amongst these are alterations in gene products and in gene dosage that affect development and reproductive success in hybrid offspring. Because of its strict parent-of-origin dependence, genomic imprinting is thought to contribute to the aberrant phenotypes observed in interspecies hybrids in mammals and flowering plants, when the abnormalities depend on the directionality of the cross. In different groups of mammals, hybrid incompatibility has indeed been linked to loss of imprinting. Aberrant expression levels have been reported as well, including imprinted genes involved in development and growth. Recent studies in humans emphasize that genetic diversity within a species can readily perturb imprinted gene expression and phenotype as well. Despite novel insights into the underlying mechanisms, the full extent of imprinted gene perturbation still remains to be determined in the different hybrid systems. Here we review imprinted gene expression in intra-and interspecies hybrids and examine the evolutionary scenarios under which imprinting could contribute to hybrid incompatibilities. We discuss effects on development and reproduction and possible evolutionary implications.

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Genetic evidence for a maternal effect locus controlling genomic imprinting and growth

Cited by 22 publications

References 49 publications

Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

What are maternal effects (and what are they not)?

Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications

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