Genetic Events in Radiation-Induced Thyroid Cancer

Nikiforov, Yuri E.

doi:10.1007/978-4-431-67885-4_14

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Risk factors for the development of thyroid cancer include female sex, 22 exposure to ionizing radiation, 23 and iodine deficiency or excess. 24,25 Less understood risk factors include female hormones 26 and obesity.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Race and Ethnicity on Thyroid Cancer Incidence

Magreni

Bann

Schubart

et al. 2015

JAMA Otolaryngol Head Neck Surg

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The incidence of thyroid cancer continues to increase in all races and ethnicities. No significant difference was observed between the increase in incidence for whites and blacks. However, the increase in incidence for non-Hispanics was significantly larger than that for Hispanics. The increase in incidence of thyroid cancer was greater in whites than in Asians/Pacific Islanders, so whites now have a higher incidence of thyroid cancer than persons of Asian/Pacific Islander descent.

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Section: Discussionmentioning

confidence: 99%

The Effects of Race and Ethnicity on Thyroid Cancer Incidence

Magreni

Bann

Schubart

et al. 2015

JAMA Otolaryngol Head Neck Surg

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“…BRAF mutations were the major genetic event (63.2%) in pediatric PTCs in Fukushima who underwent thyroidectomy in 2013 - 2014 and RET/PTC rearrangements were found in only 10.3% of cases [46]. This oncogenic profile is quite different from Chernobyl-related studies [47] but this result should be interpreted with cautions. Firstly, the thyroid equivalent doses in Fukushima (4.2 mSV) is much lower than in Chernobyl (490 mSV) [48, 49].…”

Section: Discussionmentioning

confidence: 99%

The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review

et al. 2016

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BackgroundThe genetic alterations of papillary thyroid carcinoma (PTC) have been reported to change over the past few decades. We performed this systematic review to further examine the trends and modifications of patient demographic, clinicopathological features and molecular profiles of PTC over time.MethodsA literature search was performed within six electronic databases to identify relevant articles. The inclusion criteria were published studies investigating BRAF mutations, RET/PTC rearrangements or RAS mutations in PTCs or classical PTCs. Two teams of reviewers independently screened titles and abstracts of all articles. Full texts of potential articles were read and extracted data were listed and stratified into an excel file according to country, city, institution, and surgical time period. Student t test and Pearson Chi-square were used to analyze the trends of demographic and clinicopathological features of PTC patients and the prevalence of each genetic alteration in individual institutions.ResultsFrom 3139 articles, we included 16 articles for final analysis. Our results showed an increasing trend of BRAF and a decreasing trend of RET/PTC prevalence over time in PTCs and classical PTCs, accompanied by an older age of PTC patients, an increase in proportion of PTMC and less aggressive behaviours of tumours.ConclusionsThe demographic and clinicopathological characteristics and molecular profile of PTCs have been changing over the past few decades. These modifications suggest changes in etiologies and risk factors of thyroid cancer that influence the tumorigenesis of PTCs.

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Genetic Events in Radiation-Induced Thyroid Cancer

Cited by 2 publications

References 36 publications

The Effects of Race and Ethnicity on Thyroid Cancer Incidence

The Effects of Race and Ethnicity on Thyroid Cancer Incidence

The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review

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