Genetic Effects on Structural and Functional Properties of Sensorimotor-Association Axis of Cortical Organization are Selectively Distinct

Bignardi, Giacomo; Nivard, Michel G.; Schaare, H. Lina; Bernhardt, Boris C.; Bethlehem, Richard A. I.; Fisher, Simon E.; Valk, Sofie L.

doi:10.1101/2023.07.13.548817

Cited by 2 publications

(1 citation statement)

References 68 publications

(126 reference statements)

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“…Another caveat is that individual anatomical differences may seep into functional connectivity measures when a hard parcellation is used [70,71]. However, as the literature has shown more broadly, structural brain properties can make meaningful contributions to functional connectivity and it might not be possible to fully disentangle the two [72][73][74][75].…”

Section: Limitationsmentioning

confidence: 99%

Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness

Amelink,

Postema,

Kong

et al. 2023

Preprint

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Language is supported by a distributed network of brain regions with a particular contribution from the left hemi-sphere. A multi-level understanding of this network requires studying the genetic architecture of its functional connectivity and hemispheric asymmetry. We used resting state functional imaging data from 29,681 participants from the UK Biobank to measure functional connectivity between 18 left-hemisphere regions implicated in multimodal sentence-level processing, as well as their homotopic regions in the right-hemisphere, and interhemispheric connections. Multivariate genome-wide association analysis of this total network, based on common genetic variants (with population frequencies above 1%), identified 14 loci associated with network functional connectivity. Three of these loci were also associated with hemispheric differences of intrahemispheric connectivity. Polygenic dispositions to lower language-related abilities, dyslexia and left-handedness were associated with generally reduced leftward asymmetry of functional connectivity, but with some trait- and connection-specific exceptions. Exome-wide association analysis based on rare, protein-altering variants (frequencies≤1%) suggested 7 additional genes. These findings shed new light on the genetic contributions to language network connectivity and its asymmetry based on both common and rare genetic variants, and reveal genetic links to language-related traits and hemispheric dominance for hand preference.

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Section: Limitationsmentioning

confidence: 99%

Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness

Amelink,

Postema,

Kong

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Sex differences in intrinsic functional cortical organization reflect differences in network topology rather than cortical morphometry

Serio,

Hettwer,

Wiersch

et al. 2023

Preprint

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Brain size robustly differs between sexes. However, the consequences of this anatomical dimorphism on sex differences in intrinsic brain function remain unclear. We investigated the extent to which sex differences in intrinsic cortical functional organization may be explained by differences in cortical morphometry, namely brain size, microstructure, and the geodesic distances of connectivity profiles. For this, we computed a low dimensional representation of functional cortical organization, the sensory-association axis, and identified widespread sex differences. Contrary to our expectations, observed sex differences in functional organization were not fundamentally associated with differences in brain size, microstructural organization, or geodesic distances, despite these morphometric properties beingper seassociated with functional organization and differing between sexes. Instead, functional sex differences in the sensory-association axis were associated with differences in functional connectivity profiles and network topology. Collectively, our findings suggest that sex differences in functional cortical organization extend beyond sex differences in cortical morphometry.TeaserInvestigating sex differences in functional cortical organization and their association to differences in cortical morphometry.

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Genetic Effects on Structural and Functional Properties of Sensorimotor-Association Axis of Cortical Organization are Selectively Distinct

Cited by 2 publications

References 68 publications

Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness

Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness

Sex differences in intrinsic functional cortical organization reflect differences in network topology rather than cortical morphometry

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