Genetic effects and biotoxicity monitoring of occupational styrene exposure

Rueff, José; Teixeira, João Paulo; Santos, Luís S.; Gaspar, Jorge

doi:10.1016/j.cca.2008.09.012

Cited by 55 publications

(29 citation statements)

References 148 publications

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“…The exact mechanism of mandelic acid inhibition of CTx nAChR antagonism is beyond the scope of this manuscript. We speculate that this observation may have important clinical implications for human medicine, because CTxs have been identified as promising drug development leads (Azam and McIntosh;2009), and mandelic acid is found in urine after occupational exposure to styrene monomer (Rueff et al, 2009).…”

Section: Optical Isomers Of Coniine Inhibit Fetal Movementmentioning

confidence: 99%

Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine

Green

Lee

Welch

et al. 2012

J Pharmacol Exp Ther

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Coniine is an optically active toxic piperidine alkaloid and nicotinic acetylcholine receptor (nAChR) agonist found in poison hemlock (Conium maculatum L.). Coniine teratogenicity is hypothesized to be attributable to the binding, activation, and prolonged desensitization of fetal muscle-type nAChR, which results in the complete inhibition of fetal movement. However, pharmacological evidence of coniine actions at fetal muscle-type nAChR is lacking. The present study compared (2)-coniine, (1)-coniine, and nicotine for the ability to inhibit fetal movement in a day 40 pregnant goat model and in TE-671 cells that express fetal muscle-type nAChR. Furthermore, a-conotoxins (CTx) EI and GI were used to antagonize the actions of (1)-and (2)-coniine in TE-671 cells.(2)-Coniine was more effective at eliciting electrical changes in TE-671 cells and inhibiting fetal movement than was (1)-coniine, suggesting stereoselectivity by the receptor. The pyridine alkaloid nicotine did not inhibit fetal movement in a day 40 pregnant goat model, suggesting agonist specificity for the inhibition of fetal movement. Low concentrations of both CTxs potentiated the TE-671 cell response and higher concentrations of CTx EI, and GI antagonized the actions of both coniine enantiomers demonstrating concentration-dependent coagonism and selective antagonism. These results provide pharmacological evidence that the piperidine alkaloid coniine is acting at fetal muscle-type nAChR in a concentration-dependent manner.

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Section: Optical Isomers Of Coniine Inhibit Fetal Movementmentioning

confidence: 99%

Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine

Green

Lee

Welch

et al. 2012

J Pharmacol Exp Ther

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“…Styrene is a common VOC that is widely used as a precursor for the synthesis of rubber, plastic products, resins, and polyester in synthetic industries [27][28][29] . As potentially carcinogenic species, styrene vapor can cause harm, such as the irritation of skin, eyes, and respiratory system [30][31][32] . Among all styrene vapor detection methods reported to date, gas chromatography, surface acoustic wave, and mass spectrometry are most commonly used 33,34 .…”

mentioning

confidence: 99%

Versatile bimetallic lanthanide metal-organic frameworks for tunable emission and efficient fluorescence sensing

et al. 2018

Commun Chem

180

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Developing novel lanthanide metal-organic frameworks (Ln-MOFs) to rapidly and reliably differentiate both metal ions in solution and volatile organic compounds (VOCs) in vapor is highly challenging. Here, we describe versatile Eu 3+ /Tb 3+ -MOFs based on a flexible ligand. It is noteworthy that the film fabricated using bimetallic Eu 0.47 Tb 0.63 -MOF and polyvinyl alcohol could serve as an easy and convenient luminescent platform for distinguishing different metal ions and VOCs. The luminescent film exhibits notable fingerprint correlation between the metal ions/VOCs and the emission intensity ratio of Eu 3+ /Tb 3+ ions in Ln-MOFs. As a result, the bimetallic Ln-MOFs show fast recognition of Fe 3+ ion with a response time of <10 s, and can effectively probe styrene vapor within 4 min. Since the developed Ln-MOF film is stable and reliable, this work presents a promising strategy to explore luminescent platforms capable of effectively sensing different metal ions and VOCs.

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“…As would be expected from the mouse studies with benzene, Garte et al (2008) discovered that subjects with the genotype for fast catalytic conversion of benzene, a bioactivation process, had an increased genetic susceptibility as determined by measurement of single-strand breaks in DNA. However, with respect to styrene, the studies on the importance of genetic polymorphisms in mEH are mixed, with some suggesting greater susceptibility to adverse effects and others indicating no effect (Rueff et al, 2009). Vodicka et al (2004) found that workers in a tire plant who had low mEH activity had more chromosomal aberrations than those with high activity, but the exposures were not only to styrene but also to other solvents.…”

Section: Discussionmentioning

confidence: 97%

Metabolism and Toxicity of Styrene in Microsomal Epoxide Hydrolase-Deficient Mice

Carlson

2010

Journal of Toxicology and Environmental Health, Part A

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Styrene, which is widely used in manufacturing, is both acutely and chronically toxic to mice. Styrene is metabolized by cytochromes P-450 to the toxic metabolite styrene oxide, which is detoxified via hydrolysis with microsomal epoxide hydrolase (mEH) playing a major role. The purpose of these studies was to characterize the importance of this pathway by determining the hepatotoxicity and pneumotoxicity of styrene in wild-type and mEH-deficient (mEH(-/-)) mice. While the mEH(-/-) mice metabolized styrene to styrene oxide at the same rate as the wild-type mice, as expected there was minimal metabolism of styrene oxide to glycol. mEH(-/-) mice were more susceptible to the lethal effects of styrene. Twenty-four hours following the administration of 200 mg/kg ip styrene, mice demonstrated a greater hepatotoxic response due to styrene, as measured by increased serum sorbitol dehydrogenase activity and greater pneumotoxicity as shown by increased protein levels, cell numbers, and lactate dehydrogenase activity in bronchioalveolar lavage fluid. mEH(-/-) mice were also more susceptible to styrene-induced oxidative stress, as indicated by greater decreases in hepatic glutathione levels 3 h after styrene. Styrene oxide at a dose of 150 mg/kg did not produce hepatotoxicity in either wild-type or mEH(-/-) mice. However, styrene oxide produced pneumotoxicity that was similar in the two strains. Thus, mEH plays an important role in the detoxification of styrene but not for exogenously administered styrene oxide.

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Genetic effects and biotoxicity monitoring of occupational styrene exposure

Cited by 55 publications

References 148 publications

Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine

Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine

Versatile bimetallic lanthanide metal-organic frameworks for tunable emission and efficient fluorescence sensing

Metabolism and Toxicity of Styrene in Microsomal Epoxide Hydrolase-Deficient Mice

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