Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador

Galarza, Juan Miguel; Barquera, Rodrigo; Álvarez, Ana M. Tito; Zaragoza, Diana I. Hernández; Sevilla, Gabriela Peralta; Tamayo, Andrea; Pérez, Mariel; Dávila, D.; Birnberg, Lotty; Alonzo, Víctor Acuña; Krause, Johannes; Grijalva, Marcelo

doi:10.1016/j.humimm.2018.06.004

Cited by 9 publications

(2 citation statements)

References 59 publications

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“…In Latin America AFs and HFs reported by countries bordering Colombia, such as Panamá ( 68 ), Venezuela ( 69 ), and Ecuador ( 70 ), showed frequencies similar to those described in our study, where alleles HLA-A*2, -A*24, -B*35, -DRB1*04 and -DQB1*0302 are the most frequent, and haplotype A*24~B*35~DRB1*04~DQB1*03:02 is the most frequent in Ecuador, Panamá, and Colombia. This coincidence may be explained by common migratory and historical processes over the centuries.…”

Section: Discussionmentioning

confidence: 99%

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Hernández¹,

Páez-Gutiérrez²,

Ardón³

et al. 2023

Front. Immunol.

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The HLA compatibility continues to be the main limitation when finding compatible donors, especially if an identical match is not found within the patient’s family group. The creation of bone marrow registries allowed a therapeutic option by identifying 10/10 compatible unrelated donors (URD). However, the availability and frequency of haplotypes and HLA alleles are different among ethnic groups and geographical areas, increasing the difficulty of finding identical matches in international registries. In this study, the HLA-A, -B, -C, -DRB1, and -DQB1 loci of 1763 donors registered in the Colombian Bone Marrow Registry were typed by next-generation sequencing. A total of 52 HLA-A, 111 HLA-B, 41 HLA-C, 47 HLA-DRB1, and 20 HLA-DQB1 alleles were identified. The 3 most frequent alleles for each loci were A*24:02g (20,8%), A*02:01g (16,1%), A*01:01g (7.06%); B*35:43g (7.69%), B*40:02g (7.18%), B*44:03g (6.07%); C*04:01g (15.40%), C*01:02g (10.49%), C*07:02g (10.44%); DRB1*04:07g (11.03%), DRB1*07:01g (9.78%), DRB1*08:02g (6.72%); DQB1*03:02g (20.96%), DQB1*03:01g (17.78%) and DQB1*02:01g (16.05%). A total of 497 HLA-A-C-B-DRB1-DQB1 haplotypes were observed with a frequency greater than or equal to 0.05% (> 0.05%); the haplotypes with the highest frequency were A*24:02g~B*35:43g~C*01:02g~DQB1*03:02g~DRB1*04:07g (3.34%), A*29:02g~B*44:03g~C*16:01g~DQB1*02:01g~DRB1*07:01g (2.04%), and A*01:01g~B*08:01g~C*07:01g~DQB1*02:01g~DRB1*03:01g (1.83%). This data will allow the new Colombian Bone Marrow Donor Registry to assess the genetic heterogeneity of the Colombian population and serve as a tool of interest for future searches of unrelated donors in the country.

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Section: Discussionmentioning

confidence: 99%

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Hernández¹,

Páez-Gutiérrez²,

Ardón³

et al. 2023

Front. Immunol.

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“…Studies examining the genetic ancestry of the Latin American (LATAM) populations including Mexico have revealed heterogeneous proportions of three main ancestral lineages: Amerindian, European, and African. As shown in Table 1, most LATAM countries contain all three with some having a higher degree of African (21,28) and Native American (22,27,29,30) ancestry than European (3,(23)(24)(25)(26)29). The indigenous people of Mexico are part of the third Native American migration wave that crossed the Bering Strait to the American continent around 20,000 years ago (2) (Figure 1B, blue arrow).…”

Section: Mexico's Genetic Ancestry and Sociodemographic Backgroundmentioning

confidence: 99%

Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico

Panduro,

Roman,

Mariscal-Martinez

et al. 2024

Front. Nutr.

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Chronic liver disease is a global health issue. Patients with chronic liver disease require a fresh approach that focuses on the genetic and environmental factors that contribute to disease initiation and progression. Emerging knowledge in the fields of Genomic Medicine and Genomic Nutrition demonstrates differences between countries in terms of genetics and lifestyle risk factors such as diet, physical activity, and mental health in chronic liver disease, which serves as the foundation for the implementation of Personalized Medicine and Nutrition (PerMed-Nut) strategies. Most of the world’s populations have descended from various ethnic groupings. Mexico’s population has a tripartite ancestral background, consisting of Amerindian, European, and African lineages, which is common across Latin America’s regional countries. The purpose of this review is to discuss the genetic and environmental components that could be incorporated into a PerMed-Nut model for metabolic-associated liver disease, viral hepatitis B and C, and hepatocellular carcinoma in Mexico. Additionally, the implementation of the PerMed-Nut approach will require updated medicine and nutrition education curricula. Training and equipping future health professionals and researchers with new clinical and investigative abilities focused on preventing liver illnesses in the field of genomic hepatology globally is a vision that clinicians and nutritionists should be concerned about.

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Generations of genomes: advances in paleogenomics technology and engagement for Indigenous people of the Americas

Tsosie

Begay

Fox

et al. 2020

Current Opinion in Genetics & Development

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Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador

Cited by 9 publications

References 59 publications

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico

Generations of genomes: advances in paleogenomics technology and engagement for Indigenous people of the Americas

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