Genetic diversity of penicillin G-resistant Neisseria meningitidis from Spain

Mendelman, Paul M.; Caugant, Dominique A.; Kalaitzoglou, George; Wedege, Elisabeth; Chaffin, Donald O.; Campos, José; Sáez-Nieto, Juan Antonio; Viñas, Miguel; Selander, Robert K.

doi:10.1128/iai.57.4.1025-1029.1989

Cited by 28 publications

(6 citation statements)

References 17 publications

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“…In the present study, 13 such strains were found, none of which produced beta-lactamase with the nitrocefin disk. As observed by others (5,19), these strains do not seem to arise from a single clone. Effectively, apart from the three strains related to the outbreak described by Perron and Laferrière (25), the strains belonged to serogroup B, C, or Y and had different serotypes, subtypes, and ET profiles.…”

Section: Discussionsupporting

confidence: 67%

Meningococcal infections in the Province of Québec, Canada, during the period 1991 to 1992

et al. 1995

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A total of 234 strains of Neisseria meningitidis obtained from hospitalized patients living in the province of Québec during the period 1991 to 1992 were characterized according to their serogroup, serotype, subtype, electrophoretic type, and antimicrobial susceptibility. All these strains were recovered from sterile body fluids, except for one strain that was isolated postmortem from a cutaneous lesion. For both years, serogroup C was the most prevalent (69.7%), followed by serogroup B (27.4%). Serotype 2a represented 80.3% of serogroup C isolates, and P1.2 was the most common subtype associated with this serotype. Clone ET 15 accounted for 76.5% of serogroup C isolates and 90.0% of serotype 2a strains. Although meningococcal disease occurred mostly in children under the age of 5 (9.7 cases per 100,000 children), with a peak incidence for children under 1 (20.3 cases per 100,000 children), most fatalities occurred among teenagers (12 to 19 years old). The total fatality rate was 11.5%, and serogroup C strains were responsible for 88.9% of these fatalities. Thirteen strains had a reduced susceptibility to penicillin G, and 28 strains were resistant to sulfadiazine. One strain was resistant to both rifampin and sulfadiazine and showed a reduced susceptibility to penicillin G.

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Section: Discussionsupporting

confidence: 67%

Meningococcal infections in the Province of Québec, Canada, during the period 1991 to 1992

et al. 1995

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“…Rather, this pattern supports the notion that most pathogenic bacteria within a species are composed of a limited number of clones and the genetic diversity observed is restricted to single isolates. Four resistant strains in lineage A (ETs 6, 7, 21, and 22) and all of those in lineages B and C were single representatives of distinct ETs in agreement with their individual PBP properties, confirming (15). One of the surprising results was that six ETs were represented by isolates of two or more different capsular types, the most inhomogeneous groups of strains being those represented in ET 5a and b.…”

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confidence: 64%

Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents

et al. 1992

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Sixty-six strains of Streptococcus pneumonwiae isolated in different parts of the world, 46 resistant and 22 susceptible to penicillin, were subdivided by multilocus enzyme electrophoresis into 28 distinct electrophoretic types (ETs). The ETs to which penicillin-susceptible strains were assigned differed from those containing resistant isolates of the same serotype. Five common clones could be recognized among the penicillin-resistant bacteria by combining the ETs, the antigenic properties of penicillin-binding proteins PBP la and 2b, and the tetracycline and chloramphenicol resistance profiles. Two clones were found in Finland and were associated with capsular serotypes 6B and 23F, respectively. Two clones were from Spain (type 6B and 9V, respectively). The fifth clone was isolated in South Africa and in Spain and contained both serotype 23F isolates and one type 19F strain. The other resistant strains were represented by rare isolates distributed among 12 other ETs, confirming that resistance to penicillin has evolved by multiple branches. Because capsular type was mixed in several ETs, the results also demonstrate that it may vary among very closely related pneumococci.

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“…One study found that group B serotype\subtype 4 : P1.15 was associated with 51n4 % of penicillin resistance and group C and non-serogroupable serotype type 2b were associated with 86 % and 87 % of penicillin resistance respectively [22]. However, an examination of 16 penicillin G-resistant strains in Spain failed to find a serotype specific association for penicillin resistant isolates [34]. We found that serogroups\types\subtypes B : 4 : P.14, B : NT : P1.9, B : NT : P1.16, C:2a : P1.2 and C : 2a : P1.5 were associated with a higher proportion of resistance as well as disease.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of moderate penicillin resistant invasive Neisseria meningitidis infection in Scotland, 1994–9

Kyaw

Bramley

Clarke³

et al. 2001

Epidemiol. Infect.

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We examined the serological characteristics of 774 invasive meningococcal isolates collected through an active laboratory-based surveillance system in Scotland from 1994 to 1999. Of these, 72–73% of isolates were tested for susceptibility to several antimicrobial agents. Meningococci with high-level resistance to sulphadiazine had a prevalence of 10% and incidence of 0·22 per 100000 population. High-level resistance to penicillin and other antibiotics was not detected. The prevalence of moderate penicillin resistant meningococci was 8·3%. There was no increase in moderate penicillin resistant meningococcal isolates during the study period, but there were temporal and geographic variations. The estimated incidence of moderate penicillin resistant meningococci was 0·15 per 100000 population. High and low incidence of moderate penicillin resistant meningococci appeared to correlate with the number of doses of penicillin prescribed in some geographic locations. The majority of moderate penicillin resistant isolates belonged to serogroups B (52·2%) and C (39·2%). However, the prevalence of moderate penicillin resistance in serogroup W135 was substantially higher (51·7%) than serogroups B (7·8%) and C (7·6%). Serogroup W135 accounted for a higher proportion of moderate penicillin resistance (8·7%) than disease (1%). There was no predominant penicillin resistant serotype/subtype within any serogroup. Constant surveillance is necessary to monitor the emergence and spread of resistance and to guide appropriate public health interventions in preventing drug resistant meningococci.

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Genetic diversity of penicillin G-resistant Neisseria meningitidis from Spain

Cited by 28 publications

References 17 publications

Meningococcal infections in the Province of Québec, Canada, during the period 1991 to 1992

Meningococcal infections in the Province of Québec, Canada, during the period 1991 to 1992

Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents

Prevalence of moderate penicillin resistant invasive Neisseria meningitidis infection in Scotland, 1994–9

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